Results 121 to 130 of about 271,915 (352)

Single‐Cell Dissection of the Biological Function and Molecular Features Underlying the Micropeptide LSMEM1 in Kidney

open access: yesAdvanced Science, EarlyView.
LSMEM1, an evolutionarily conserved micropeptide with extreme hydrophobicity (aliphatic index═113) and dynamic amphiphilicity (GRAVY═0.017), features a strong α‐helical transmembrane anchor (residues 64‐86). Single‐cell analysis reveals its critical role in renal lipid homeostasis.
Peimin Liu   +11 more
wiley   +1 more source

Vascular dementia: Current concepts and nomenclature harmonization. [PDF]

open access: yes, 2012
Several types of cerebrovascular lesions are associated with cognitive decline, but the role of each type in dementia manifestation has yet to be determined.
Grinberg, Lea Tenenholz
core  

Phospholipid Remodeling and Tri‐Layer Membrane Reconstruction Mediate Cognitive Effects of Humanized Milk Fat Globules in Neonatal Rats

open access: yesAdvanced Science, EarlyView.
Humanized milk fat globules (MFG) mimic the native composition and structure of human milk, achieved through remodeling of milk fat globule membrane phospholipid composition and reconstruction of the tri‐layer membrane structure. These humanized MFG exhibit improved structural stability and digestibility, and enhance neurodevelopment in formula‐fed rat
Shaolei Wang   +8 more
wiley   +1 more source

Differential Features of Culprit Intracranial Atherosclerotic Lesions: A Whole-Brain Vessel Wall Imaging Study in Patients With Acute Ischemic Stroke. [PDF]

open access: yes, 2018
BackgroundIntracranial atherosclerotic disease tends to affect multiple arterial segments. Using whole-brain vessel wall imaging, we sought to study the differences in plaque features among various types of plaques in patients with a recent unilateral ...
Bi, Xiaoming   +12 more
core  

Familial Incidence of Cerebral Hemorrhage [PDF]

open access: yesStroke, 1973
The frequency of death certified as due to cerebral hemorrhage among the brothers and sisters of 180 index patients with a proved cerebral hemorrhage has been compared with its frequency in the population of the same age and sex at the same decennium of the century as given by the Registrar General.
openaire   +3 more sources

Targeting ROCK2 to Restore Epileptic Synaptic Networks via Mitophagy Activation: Insights from Translational Imaging of SV2A In Vivo

open access: yesAdvanced Science, EarlyView.
By integrating synaptic vesicle glycoprotein 2A PET imaging and transcriptomics, this study identifies Rho‐associated protein kinase 2 (ROCK2) as a critical regulator of synaptic network dysfunction in temporal lobe epilepsy. Pharmacological ROCK2 inhibition restores synaptic density and enhances mitophagy, thereby reducing seizures and neuronal damage.
Ling Xiao   +14 more
wiley   +1 more source

Advanced Image‐Guidance and Surgical‐Navigation Techniques for Real‐Time Visualized Surgery

open access: yesAdvanced Science, EarlyView.
This review comprehensively summarizes advances in surgical navigation, covering both established and emerging intraoperative imaging technologies. It highlights mechanisms, advantages, limitations, and clinical applications, while emphasizing interdisciplinary collaboration.
Xiaoxiao Fan   +9 more
wiley   +1 more source

Refractory Status Epilepticus and Therapeutic Uncertainties: a Comprehensive Review on Targeting Neuroinflammation and Rationale for Developing a Platform Trial

open access: yesAdvanced Science, EarlyView.
Refractory status epilepticus (RSE) is a life‐threatening neurological emergency with high rates of death and long‐term disability, but treatments for it are often based on limited evidence. RSE is now understood to involve neuroinflammation, which has led to the exploration of anti‐inflammatory and immunomodulatory agents like Tocilizumab. Traditional
Shanika Samarasekera   +12 more
wiley   +1 more source

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