Weakly supervised deep learning-based intracranial hemorrhage localization [PDF]
arXiv, 2021 Intracranial hemorrhage is a life-threatening disease, which requires fast medical intervention. Owing to the duration of data annotation, head CT images are usually available only with slice-level labeling. This paper presents a weakly supervised method of precise hemorrhage localization in axial slices using only position-free labels, which is based ...
arxiv
Randomized, open-label, phase 1/2a study to determine the maximum tolerated dose of intraventricular sustained release nimodipine for subarachnoid hemorrhage (NEWTON [Nimodipine Microparticles to Enhance Recovery While Reducing Toxicity After Subarachnoid Hemorrhage]) [PDF]
, 2016 BACKGROUND AND PURPOSE—: We conducted a randomized, open-label, phase 1/2a, dose-escalation study of intraventricular sustained-release nimodipine (EG-1962) to determine safety, tolerability, pharmacokinetics, and clinical effects in aneurysmal ...
Aldrich, Francois +10 more
core +3 more sources
Longitudinal, Multimodal Tracking Reveals Lasting Neurovascular Impact of Individual Microinfarcts
Advanced Science, EarlyView.Jin et al. investigate the neurovascular impact of microinfarcts, revealing transient neural suppression with minimal cell death and recovery linked to vascular remodeling. Fast‐spiking interneurons exhibit reduced excitability, whereas regular‐spiking neurons showed increased bursting activity. Disruptions in low‐gamma phase locking suggest persistent
Yifu Jin +9 more
wiley +1 more source
Medium‐chain Acyl‐COA dehydrogenase deficiency: Pathogenesis, diagnosis, and treatment
Endocrinology, Diabetes &Metabolism, Volume 6, Issue 1, January 2023., 2023 MCADD is a commonly inherited metabolic disease with serious implications for health outcomes, particularly in children, that may be successfully managed with proper intervention. In this review, we discuss the genetics, pathogenesis, clinical presentation, diagnosis, and treatments for Medium‐Chain Acyl‐CoA Dehydrogenase Deficiency (MCADD ...
Emily Mason +2 more
wiley +1 more source
Comorbidities of patients in tiotropium clinical trials : comparison with observational studies of patients with chronic obstructive pulmonary disease [PDF]
, 2015 Acknowledgments The authors are fully responsible for all content and editorial decisions made, were involved at all stages of manuscript development, and have approved the final version for publication.
Celli, Bartolome +5 more
core +1 more source
Canadian Respiratory Journal, 2017 Ventilator-associated pneumonia (VAP) is a predominant factor of pulmonary infection. We analyzed the risk factors of VAP with acute cerebral hemorrhage in intensive care unit (ICU) by univariate and multivariate logistic regression analyses.
Li Chang, Yun Dong, P. Zhou
semanticscholar +1 more source
Biomedical Applications of Gadolinium‐Containing Biomaterials: Not Only MRI Contrast Agent
Advanced Science, EarlyView.This paper summarizes the latest applications and potential mechanisms of the rare earth element gadolinium in biomedical fields, in addition to its traditional application as an MRI contrast agent, including osteogenesis, antimicrobial, antitumor, bioimaging, bioprobes, and so on.
Xingtong Pan +9 more
wiley +1 more source
Solvent and mutation effects on the nucleation of amyloid $β$-protein folding [PDF]
, 2005 Experimental evidence suggests that the folding and aggregation of the amyloid $\beta$-protein (A$\beta$) into oligomers is a key pathogenetic event in Alzheimer's disease (AD). Inhibiting the pathologic folding and oligomerization of A$\beta$ could be effective in the prevention and treatment of AD.
arxiv +1 more source
Blood pressure in acute intra-cerebral hemorrhage.
Annals of Translational Medicine, 2016 Cerebrovascular disease represents a leading cause of mortality and morbidity worldwide, and the spontaneous non-traumatic intra-cerebral hemorrhage (ICH) is the stroke subtype characterized by the poorer prognosis.
S. Lattanzi, M. Silvestrini
semanticscholar +1 more source
AGING MEDICINE, EarlyView.The prevalence of neurologically asymptomatic CSVD is common in the nondiabetic population. Glycated hemoglobin A1c correlated with periventricular white matter hyperintensities. Fasting blood glucose was associated with deep cerebral microbleeds. Better control of blood glucose may have a beneficial effect on reducing the risk of CSVD.
Xinxin Ma +7 more
wiley +1 more source