Results 161 to 170 of about 1,314,540 (419)

Isolated aneurysmal disease as an underestimated finding in individuals with JAG1 pathogenic variants

Human Mutation, Volume 43, Issue 12, Page 1824-1828, December 2022., 2022
Abstract Pathogenic variants in JAG1 are known to cause Alagille syndrome (ALGS), a disorder that primarily affects the liver, lung, kidney, and skeleton. Whereas cardiac symptoms are also frequently observed in ALGS, thoracic aortic aneurysms have only been reported sporadically in postmortem autopsies.
Jotte Rodrigues Bento, Alice Krebsová, Ilse Van Gucht, Irene Valdivia Callejon, An Van Berendoncks, Pavel Votypka, Ilse Luyckx, Petra Peldova, Steven Laga, Marek Havelka, Lut Van Laer, Pavel Trunecka, Nele Boeckx, Aline Verstraeten, Milan Macek, Josephina A. N. Meester, Bart Loeys   +16 more
wiley   +1 more source

The Neurocardiogenic Spectrum in Subarachnoid Hemorrhage: A Case Report and Review of the Literature

Clinical Practice and Cases in Emergency Medicine, 2017
A 36-year-old man was brought to our emergency department after successful resuscitation of out-of-hospital cardiac arrest with the whole spectrum of neurocardiogenic effects in subarachnoid hemorrhage: electrocardiographic changes, regional wall motion ...
Gregory Mansella, Raban Jeger, Roland Bingisser, Christian H. Nickel   +3 more
doaj   +1 more source

Detecting intracranial aneurysm rupture from 3D surfaces using a novel GraphNet approach [PDF]

arXiv, 2019
Intracranial aneurysm (IA) is a life-threatening blood spot in human's brain if it ruptures and causes cerebral hemorrhage. It is challenging to detect whether an IA has ruptured from medical images. In this paper, we propose a novel graph based neural network named GraphNet to detect IA rupture from 3D surface data.
arxiv  

The future of ischemic stroke: flow from prehospital neuroprotection to definitive reperfusion. [PDF]

, 2014
Recent advances in ischemic stroke enable a seamless transition of the patient flow from the prehospital setting to definitive reperfusion, without the arbitrary separation of therapeutic phases of ischemia based on time alone.
Ip, Hing Lung, Liebeskind, David S
core   +1 more source

Brain hemorrhage recurrence, small vessel disease type, and cerebral microbleeds

Neurology, 2017
Objective: We evaluated recurrent intracerebral hemorrhage (ICH) risk in ICH survivors, stratified by the presence, distribution, and number of cerebral microbleeds (CMBs) on MRI (i.e., the presumed causal underlying small vessel disease and its severity)
A. Charidimou, T. Imaizumi, S. Moulin, A. Biffi, N. Samarasekera, Y. Yakushiji, A. Peeters, Y. Vandermeeren, P. Laloux, J. Baron, M. Hernández-Guillamon, J. Montaner, B. Casolla, S. Gregoire, D. Kang, Jong S. Kim, H. Naka, Eric E. Smith, A. Viswanathan, H. Jäger, R. Salman, S. Greenberg, C. Cordonnier, D. Werring   +23 more
semanticscholar   +1 more source

Transplanting neural stem cells overexpressing miRNA‐21 can promote neural recovery after cerebral hemorrhage through the SOX2/LIN28‐let‐7 signaling pathway

Animal Models and Experimental Medicine, EarlyView.
Abstract Background Intracerebral hemorrhage (ICH) remains a devastating neurological disorder with limited therapeutic options. Neural stem cell (NSC)‐based therapies have emerged as a potential regenerative approach, yet the molecular mechanisms regulating NSC behavior require further elucidation.
Wei Dai, Yongxia Li, Jiarui Du, Gang Shen, Meimei Fan, Zuopeng Su, Fulin Xu, Fang Yuan   +7 more
wiley   +1 more source

The roles of endoglin gene in cerebrovascular diseases. [PDF]

, 2017
Endoglin (ENG, also known as CD105) is a transforming growth factor β (TGFβ) associated receptor and is required for both vasculogenesis and angiogenesis.
Ma, Li, Su, Hua, Zhang, Rui, Zhu, Wan
core   +2 more sources

Krüppel‐like factor 4 transcription factor in blood–brain barrier endothelial cells: A potential role in Alzheimer's disease

Animal Models and Experimental Medicine, EarlyView.
KLF4 (Krüppel‐like factor 4) plays a protective role in blood–brain barrier (BBB). KLF4 plays an ambiguous role in the central nervous system. KLF4 in the BBB endothelial cells could be a potential target for Alzheimer's disease. Abstract Alzheimer's disease is the most prevalent chronic neurodegenerative disorder worldwide, with no sufficient cure ...
Ziying Wei, Chunhua Liu, Jianyu Chen, Yuxiao Yao, Dajiang Qin   +4 more
wiley   +1 more source

PREDICT‐GTN 1: Can we improve the FIGO scoring system in gestational trophoblastic neoplasia?

International Journal of Cancer, Volume 152, Issue 5, Page 986-997, 1 March 2023., 2023
What's new? The International Federation of Gynaecology and Obstetrics (FIGO) scoring system is used to predict resistance to first‐line single‐agent chemotherapy in gestational trophoblastic neoplasia (GTN) patients. HoweThis system is imperfect, however—one‐third of low‐risk patients develop resistance, and resistance rates increase with FIGO score ...
Victoria L. Parker, Matthew C. Winter, John A. Tidy, Barry W. Hancock, Julia E. Palmer, Naveed Sarwar, Baljeet Kaur, Katie McDonald, Xianne Aguiar, Kamaljit Singh, Nick Unsworth, Imran Jabbar, Allan A. Pacey, Robert F. Harrison, Michael J. Seckl   +14 more
wiley   +1 more source

Evaluating Aspirin’s Efficacy for Primary Prevention in Cardiovascular and Cerebrovascular Disease: Insights from a Nationwide Cohort Study

Clinics and Practice
Background: The effectiveness of aspirin for the primary prevention of cerebro-cardiovascular diseases in Koreans remains unclear. Therefore, we evaluated the preventive effects of low-dose aspirin (equal or less than 100 mg) on cerebro-cardiovascular ...
Ki-Hong Kim, Inseok Ko, Jong-Yeup Kim, Dong-Kyu Kim   +3 more
doaj   +1 more source