Results 161 to 170 of about 150,877 (243)

Hypoxic Postconditioning Offers Neuroprotection Against Transient Cerebral Ischemia via Down-Regulation of rno_piR_011022. [PDF]

CNS Neurosci Ther
Chen M, Duan S, Chai G, Zhan L, Peng L, Sun W, Xu E.   +6 more
europepmc   +1 more source

Emerging Target Discovery Strategies Drive the Decoding of Therapeutic Power of Natural Products and Further Drug Development: A Case Study of Celastrol

Exploration, EarlyView.
Using celastrol as a case study, this review summarizes various target discovery strategies for natural products, including chemical proteomics, protein microarray, degradation‐based protein profiling, proteome‐wide label‐free approaches, network pharmacology, target‐based drug screening, and indirect strategies.
Yanbei Tu, Guiyu Dai, Yanyan Chen, Lihua Tan, Hanqing Liu, Meiwan Chen   +5 more
wiley   +1 more source

ncRNAs-Mediated Pyroptosis in Cerebral Ischemia-Reperfusion Injury: Pathophysiology, Mechanisms, and Therapeutic Perspectives. [PDF]

Curr Issues Mol Biol
Xu R, Peng Q, Chen W, Cheng X, Wang G.
europepmc   +1 more source

Failure of the somatosensory evoked potential following middle cerebral artery occlusion and high-grade ischemia in the cat--effects of hemodilution. [PDF]

, 1986
Philip E. Coyer, James E. Lesnick, John J. Michele, Frederick A. Simeone   +3 more
openalex   +1 more source

Engineered Exosome‐Based Senolytic Therapy Alleviates Stroke by Targeting p21+CD86+ Microglia

Exploration, EarlyView.
We identified a harmful immune cell type, p21+CD86+ microglia, driving post‐stroke inflammation and developed a targeted exosome‐based therapy (Que@micro‐Exo) to eliminate these cells. This innovative treatment reduced inflammation, alleviated brain damage, and improved recovery in stroke models, offering a promising strategy for stroke and other ...
Jialei Yang, Shipo Wu, Miao He
wiley   +1 more source

Erratum: SENP3-mediated deSUMOylation of c-Jun facilitates microglia-induced neuroinflammation after cerebral ischemia and reperfusion injury. [PDF]

iScience
Xia Q, Mao M, Zhan G, Luo Z, Zhao Y, Li X.   +5 more
europepmc   +1 more source

EFFECT OF THE EXCITATORY AMINO ACID ANTAGONIST MK-801 ON NEUROLOGIC FUNCTION FOLLOWING COMPLETE CEREBRAL ISCHEMIA IN PRIMATES [PDF]

, 1988
William L. Lanier, William J. Perkins, Bent Ole Ruud, James H. Milde, John D. Michenfelder   +4 more
openalex   +1 more source

Exploring the Neuroprotective Role of Selenium: Implications and Perspectives for Central Nervous System Disorders

Exploration, EarlyView.
Selenium (Se) is a crucial element in selenoproteins, key biomolecules for physiological function in vivo. Central nervous system can express all 25 kinds of selenoproteins, which protect neurons by reducing oxidative stress and inflammatory response. Neuroprotection is being investigated through the biological study of Se.
Guanning Huang, Ying Liu, Xiadong Zhu, Lizhen He, Tianfeng Chen   +4 more
wiley   +1 more source

Identification of potential biomarkers of cuproptosis in cerebral ischemia. [PDF]

Front Nutr
Qin L, Cao X, Huang T, Liu Y, Li S.
europepmc   +1 more source

TSG-6 Protects Against Cerebral Ischemia-Reperfusion Injury via Upregulating Hsp70-1B in Astrocytes. [PDF]

CNS Neurosci Ther
Qu Y, Yi L, Tang Y, Yang F, Pan BF, Shi S, Qu C, Li F, Wen S, Pan Y.   +9 more
europepmc   +1 more source