Results 171 to 180 of about 1,244,067 (429)

Clonal Hematopoiesis and Thrombosis

American Journal of Hematology, EarlyView.
ABSTRACT Clonal hematopoiesis (CH) has been the focus of many research efforts in the last years and has emerged as a risk modifier for cardiovascular disease morbidity and mortality. While substantial evidence has accumulated regarding its impact on arterial system diseases, the connection with venous thrombosis has only recently been explored.
Cornelia Englisch, Cihan Ay
wiley   +1 more source

Requirement for preclinical prioritization of neuroprotective strategies in stroke: Incorporation of preconditioning [PDF]

Conditioning Medicine, 2018, 2019
Acute neuroprotection in numerous human clinical trials has been an abject failure. Major systemic-and procedural-based issues have subsequently been identified in both clinical trials and preclinical animal model experimentation. As well, issues related to the neuroprotective moiety itself have contributed to clinical trial failures, including late ...
arxiv  

Alzheimer's Association clinical practice guideline for the Diagnostic Evaluation, Testing, Counseling, and Disclosure of Suspected Alzheimer's Disease and Related Disorders (DETeCD‐ADRD): Executive summary of recommendations for primary care

Alzheimer's &Dementia, EarlyView.
Abstract US clinical practice guidelines for the diagnostic evaluation of cognitive impairment due to Alzheimer's disease (AD) or AD and related dementias (ADRD) are decades old and aimed at specialists. This evidence‐based guideline was developed to empower all—including primary care—clinicians to implement a structured approach for evaluating a ...
Alireza Atri, Bradford C. Dickerson, Carolyn Clevenger, Jason Karlawish, David Knopman, Pei‐Jung Lin, Mary Norman, Chiadi Onyike, Mary Sano, Susan Scanland, Maria Carrillo   +10 more
wiley   +1 more source

Arachidonic Acid and Cerebral Ischemia Risk: A Systematic Review of Observational Studies

Cerebrovascular Diseases Extra, 2014
Background: Arachidonic acid (ARA) is a precursor of various lipid mediators. ARA metabolites such as thromboxane A2 cause platelet aggregation and vasoconstriction, thus may lead to atherosclerotic disease.
Mai Sakai, Saki Kakutani, Hisanori Tokuda, Toshihide Suzuki, Masaru Kominami, Kahori Egawa, Kayo Saito, Tomohiro Rogi, Hiroshi Kawashima, Hiroshi Shibata, Satoshi Sasaki   +10 more
doaj   +1 more source

Potassium channel activators protect the N-methyl-D-aspartate-induced cerebral vascular dilation after combined hypoxia and ischemia in piglets [PDF]

, 1998
Background and Purpose-Cerebral arteriolar dilation to N-methyl-D-aspartate (NMDA) is a neuronally mediated multistep process that is sensitive to cerebral hypoxia and ischemia (H/I).
Bari, Ferenc, Domoki, Ferenc, Veltkamp, R.   +2 more
core  

Cerebral autoregulation, spreading depolarization, and implications for targeted therapy in brain injury and ischemia [PDF]

Cerebral autoregulation is an intrinsic myogenic response of cerebral vasculature that allows for preservation of stable cerebral blood flow levels in response to changing systemic blood pressure.
Carlson, Andrew P, Cole, Chad, Marquez, Joshua, Mayer, Andrew R, Shuttleworth, C William, Stevenson, Taylor C, van der Horn, Harm J   +6 more
core   +1 more source

Resveratrol Protects Neurons and the Myocardium by Reducing Oxidative Stress and Ameliorating Mitochondria Damage in a Cerebral Ischemia Rat Model

Cellular Physiology and Biochemistry, 2014
Background: Resveratrol has shown potent antioxidant activity in ischemia models. The present study was performed to determine whether resveratrol protects against cerebral ischemia-induced neuronal and myocardial injury by interfering with mitochondrial
Ran Wang, Yan-yan Liu, Xiao-Yu Liu, Shu-wei Jia, Jian Zhao, D. Cui, Ling Wang   +6 more
semanticscholar   +1 more source

Early functional and structural hippocampal impairment in a bilateral common carotid artery stenosis mouse model

Animal Models and Experimental Medicine, EarlyView.
Our study used behavioral tests, laser speckle flowmetry, long‐term potentiation, histochemical staining, molecular experiments, and voxel‐based morphometry to evaluate the hippocampal impairments. It demonstrates early functional and structural impairments in the hippocampus contributing to learning and memory deficits after 1 month of BCAS ...
Ping Tang, Yi Sun, Chunsheng Yang, Nan Zhang   +3 more
wiley   +1 more source

Targeting signaling pathways in neurodegenerative diseases: Quercetin's cellular and molecular mechanisms for neuroprotection

Animal Models and Experimental Medicine, EarlyView.
Quercetin regulates signaling pathways in neurodegenerative diseases, including NF‐κB, sirtuins, and PI3K/Akt. Studies show quercetin improves symptoms and pathology in neurodegenerative models. The study aims to incorporate laboratory research into practical medical treatment, focusing on quercetin's neuroprotective effects and optimal dosage ...
Md. Rezaul Islam, Md. Ibrahim Khalil Al‐Imran, Mehrukh Zehravi, Sherouk Hussein Sweilam, Mohammad Rakib Mortuza, Jeetendra Kumar Gupta, Thukani Sathanantham Shanmugarajan, Kadirvel Devi, Tanuja Tummala, Mohammed Ali Alshehri, Kalirajan Rajagopal, Mohammed Asiri, Irfan Ahmad, Talha Bin Emran   +13 more
wiley   +1 more source

Atrial amyloidosis: mechanisms and clinical manifestations

European Journal of Heart Failure, Volume 24, Issue 11, Page 2019-2028, November 2022., 2022
Atrial amyloidosis: pathophysiology and clinical manifestations. Atrial amyloidosis can manifest as part of a systemic disorder (as in amyloid light‐chain [AL] or transthyretin [ATTR] amyloidosis), or be isolated (in the form due to atrial natriuretic type [ANP] accumulation); this last form is often associated with permanent or persistent atrial ...
Giuseppe Vergaro, Alberto Aimo, Claudio Rapezzi, Vincenzo Castiglione, Iacopo Fabiani, Angela Pucci, Gabriele Buda, Claudio Passino, Josep Lupón, Antoni Bayes‐Genis, Michele Emdin, Eugene Braunwald   +11 more
wiley   +1 more source