Results 291 to 300 of about 1,244,067 (429)

Drug delivery pathways to the central nervous system via the brain glymphatic system circumventing the blood‐brain barrier

Exploration, EarlyView.
The discovery of the glymphatic system has opened up a pathway for drug delivery to the brain by circumventing the blood‐brain barrier, which can effectively improve drug utilization. The methods of drug delivery through the glymphatic system include intrathecal injection, intranasal injection, and delivery through the meningeal lymphatic vessels.
Xiang Wang, Yue Yin, Huaijuan Zhou, Bowen Chi, Ling Guan, Pei Li, Jinhua Li, Yilong Wang   +7 more
wiley   +1 more source

Cerebral blood flow and tissue metabolism in experimental cerebral ischemia of spontaneously hypertensive rats with hyper-, normo-, and hypoglycemia. [PDF]

, 1986
S. Ibayashi, Motonobu Fujishima, Seizo Sadoshima, Fujio Yoshida, Osamu Shiokawa, Jun Ogata, T Omae   +6 more
openalex   +1 more source

Erratum: SENP3-mediated deSUMOylation of c-Jun facilitates microglia-induced neuroinflammation after cerebral ischemia and reperfusion injury. [PDF]

iScience
Xia Q, Mao M, Zhan G, Luo Z, Zhao Y, Li X.   +5 more
europepmc   +1 more source

Engineered Exosome‐Based Senolytic Therapy Alleviates Stroke by Targeting p21+CD86+ Microglia

Exploration, EarlyView.
We identified a harmful immune cell type, p21+CD86+ microglia, driving post‐stroke inflammation and developed a targeted exosome‐based therapy (Que@micro‐Exo) to eliminate these cells. This innovative treatment reduced inflammation, alleviated brain damage, and improved recovery in stroke models, offering a promising strategy for stroke and other ...
Jialei Yang, Shipo Wu, Miao He
wiley   +1 more source

Effect of nimodipine on cerebral functional and metabolic recovery following ischemia in the rat brain. [PDF]

, 1986
Hideo Mabe, Hiroyuki Nagai, Tsutomu Takagi, S Umemura, Masuo Ohno   +4 more
openalex   +1 more source

TSG-6 Protects Against Cerebral Ischemia-Reperfusion Injury via Upregulating Hsp70-1B in Astrocytes. [PDF]

CNS Neurosci Ther
Qu Y, Yi L, Tang Y, Yang F, Pan BF, Shi S, Qu C, Li F, Wen S, Pan Y.   +9 more
europepmc   +1 more source

Exploring the Neuroprotective Role of Selenium: Implications and Perspectives for Central Nervous System Disorders

Exploration, EarlyView.
Selenium (Se) is a crucial element in selenoproteins, key biomolecules for physiological function in vivo. Central nervous system can express all 25 kinds of selenoproteins, which protect neurons by reducing oxidative stress and inflammatory response. Neuroprotection is being investigated through the biological study of Se.
Guanning Huang, Ying Liu, Xiadong Zhu, Lizhen He, Tianfeng Chen   +4 more
wiley   +1 more source

THBS1 in macrophage-derived exosomes exacerbates cerebral ischemia-reperfusion injury by inducing ferroptosis in endothelial cells. [PDF]

J Neuroinflammation
Liu C, Sui H, Li Z, Sun Z, Li C, Chen G, Ma Z, Cao H, Xi H.   +8 more
europepmc   +1 more source

Cerebral Ischemia in Rabbit: A New Experimental Model with Immunohistochemical Investigation

, 1985
Kazumi Yamamoto, Toshiki Yoshimine, Takehiko Yanagihara   +2 more
openalex   +1 more source

Effect of mannitol, nimodipine, and indomethacin singly or in combination on cerebral ischemia in rats. [PDF]

, 1988
Garnette R. Sutherland, Howard Lesiuk, R Bose, Anders A. F. Sima   +3 more
openalex   +1 more source