Results 341 to 350 of about 1,149,621 (388)
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Therapeutics for Focal Cerebral Ischemia
Neurosurgery, 1980A review of the therapeutic modalities available for the treatment of focal cerebral ischemia is presented. The theoretical aspects and present practical applications of each treatment are discussed. The possibilities for future research and for the implementation of new modalities are indicated.
Warren R. Selman, Robert F. Spetzler
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Electrophysiology of cerebral ischemia
Neuropharmacology, 2008Organized brain activity requires the coordinated firing of vast numbers of nerve cells. To maintain this, all these cells must be adequately polarized, their axons capable of conducting action potentials and releasing transmitters at an even greater numbers of synapses. Hence the often dire consequences of any interruption in the normal supply of O(2)
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Total Cerebral Ischemia in the Dog
Archives of Surgery, 1962In a previous report1we described a simple method of selectively cooling the brain as a possible method of allowing prolonged interruption of the cerebral circulation. It was apparent then that exact knowledge of the time tolerance of the brain to ischemia at various cerebral temperatures was needed if this technique was going to be applied clinically.
Robert J. Boyd, John E. Connolly
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Effects of cerebral ischemia in mice deficient in neuronal nitric oxide synthase.
Science, 1994The proposal that nitric oxide (NO) or its reactant products mediate toxicity in brain remains controversial in part because of the use of nonselective agents that block NO formation in neuronal, glial, and vascular compartments. In mutant mice deficient
Zhihong Huang +5 more
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Polyamines and cerebral ischemia
1998It has been well established that alterations in polyamine metabolism are associated with animal models of global ischemia. Recently, this has been extended to include models of focal ischemia and traumatic brain injury. There is much evidence to support the idea that polyamines may play a multifaceted detrimental role following ischemia reperfusion ...
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Adenosine Receptors in Cerebral Ischemia
2014Ischemic stroke is a complex pathology characterized by a sequence of events that evolve over time and space. It is the second leading cause of death and the main cause of adult long-term disability in developed countries. At the moment, there is no promising pharmacotherapy for acute ischemic stroke.
MELANI, ALESSIA +2 more
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Surface functionalized exosomes as targeted drug delivery vehicles for cerebral ischemia therapy.
Biomaterials, 2018Tian Tian +10 more
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Excitotoxicity in Cerebral Ischemia
2004The hypothesis that cerebral ischemia may recognize an excitoxic pathophysiological component is supported by a number of consolidated arguments, including the neuroprotective activity of glutamate receptor antagonists in experimental animal models and the use of anti-excitotoxic agents in clinical trials for stroke. Despite the dramatic results in the
Flavio Moroni +2 more
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Apoptosis and Cerebral Ischemia
Cerebrovascular Diseases, 2000Wolfgang Kuschinsky, Frank Gillardon
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