Results 131 to 140 of about 211,077 (381)

Research progress of cerebral small vessel disease

Chinese Journal of Contemporary Neurology and Neurosurgery, 2015
Cerebral small vessel disease refers to a group of pathological processes with various etiologies that affect small arteries, arterioles, venules, and capillaries of the brain. Recently, the researches of cerebral small vessel disease have got initial
Jun-dong JIA, Wei-dong YUE
doaj  

Long Term High‐Salt Diet Induces Cognitive Impairments via Down‐Regulating SHANK1

Advanced Science, EarlyView.
The study identifies a novel mechanistic link between long‐term HS diet and cognitive impairment, wherein PKA/CREB axis inactivation leads to SHANK1 reduction, synaptic damage, and cognitive deficits. Abstract High‐salt (HS) diet is an established risk factor for cognitive impairment, but the underlying mechanisms remain unclear.
Cuiping Guo, Yuanyuan Li, Wensheng Li, Tongrui Wu, Yi Liu, Yacoubou Abdoul Razak Mahaman, Jianzhi Wang, Rong Liu, Wei Liu, Hui Shen, Xiaochuan Wang   +10 more
wiley   +1 more source

Cerebral blood flow and cognition after 3 months tadalafil treatment in small vessel disease (ETLAS-2): study protocol for a randomized controlled trial

Trials
Background Targeted treatment is highly warranted for cerebral small vessel disease, a causal factor of one in four strokes and a major contributor to vascular dementia.
Joakim Ölmestig, Kristian Nygaard Mortensen, Birgitte Fagerlund, Nadia Naveed, Mette Maria Nordling, Hanne Christensen, Helle Klingenberg Iversen, Mai Bang Poulsen, Hartwig Roman Siebner, Christina Kruuse   +9 more
doaj   +1 more source

Mechanisms of Cognitive Impairment in Cerebral Small Vessel Disease: Multimodal MRI Results from the St George's Cognition and Neuroimaging in Stroke (SCANS) Study. [PDF]

, 2013
Cerebral small vessel disease (SVD) is a common cause of vascular cognitive impairment. A number of disease features can be assessed on MRI including lacunar infarcts, T2 lesion volume, brain atrophy, and cerebral microbleeds.
A Nitkunan, A Nitkunan, A Viswanathan, A Zhou, Andrew D. MacKinnon, Andrew J. Lawrence, AZ Burzynska, B Grassiot, B Patel, Bhavini Patel, C Cordonnier, C Junqué, CAM Wheeler-Kingshott, CM Fisher, DJ Werring, E Englund, EE Smith, EE Smith, F Fazekas, Hugh S. Markus, IA Awad, J Bamford, J Grimaud, JC van Swieten, Jean-Claude Baron, L Pantoni, M Duering, M Holtmannspötter, M Jenkinson, M Neeman, M O'Sullivan, M O'Sullivan, M O'Sullivan, N Shiee, Philip M. Rich, PJ Basser, PS Sachdev, R Della Nave, R Schmidt, RA Charlton, RA Charlton, Robin G. Morris, SK Song, SM Smith, SW Seo, Thomas R. Barrick, U Khan, Y Nagahama   +47 more
core   +3 more sources

Radiation Exposure Induced Blood–Brain Barrier Injury via Mitochondria‐Mediated Sterile Inflammation

Advanced Science, EarlyView.
This work describes a blood–brain barrier (BBB) microphysiological system (MPS) to explore the responses of BBB to radiation exposure. Following radiation exposure, obvious BBB comprise and brain endothelial injuries are detected. Mechanism study shows radiation induced significant sterile inflammation via mitochondrial dysfunction and cGAS‐STING ...
Peng Wang, Jiayue Liu, Min Zhang, Juan Yang, Peihan Lian, Xiu Cheng, Jianhua Qin   +6 more
wiley   +1 more source

Study on the efficacy of compound porcine cerebroside and ganglioside injection in patients with ischemic stroke: A randomized, single‐center, open‐label, prospective study

Ibrain, EarlyView., 2023
Compound porcine perebroside and ganglioside injection (CPCGI) was used to treat ischemic stroke. However, there was no clinical evidence of low‐dose CPCGI. We conducted a clinical study to analyze whether the clinical results of low‐dose and standard‐dose CPCGI in patients with ischemic stroke were different.
Ya Chen, Xia Zhang, Hai‐Qing Zhang, Zhong Luo, Xue‐Jiao Zhou, Tao Liang, Fei Yang, Jun Zhang, Zu‐Cai Xu   +8 more
wiley   +1 more source

Advances in biomarkers of cerebral small vessel disease

Journal of Neurorestoratology, 2019
Cerebral small vessel disease (CSVD) refers to a type of syndrome caused by lesions in perforating arteries, small veins, small arteries, or capillaries, resulting in clinical, imaging, or pathological alterations.
Xue Peng, Jianhua Zhao, Junli Liu, Shaomin Li   +3 more
doaj   +1 more source

Cerebral Small Vessel Disease: A Review Focusing on Pathophysiology, Biomarkers, and Machine Learning Strategies

Journal of Stroke, 2018
Cerebral small vessel disease (cSVD) has a crucial role in lacunar stroke and brain hemorrhages and is a leading cause of cognitive decline and functional loss in elderly patients.
E. Cuadrado-Godia, Pratistha Dwivedi, Sanjiv Sharma, A. Ois Santiago, J. Roquer González, M. Balcells, J. Laird, M. Turk, Harman S. Suri, A. Nicolaides, L. Saba, N. Khanna, J. Suri   +12 more
semanticscholar   +1 more source

Intracranial hemodynamic relationships in patients with cerebral small vessel disease

Neurology, 2020
Objective To investigate cerebrovascular reactivity (CVR), blood flow, vascular and CSF pulsatility, and their independent relationship with cerebral small vessel disease (SVD) features in patients with minor ischemic stroke and MRI evidence of SVD ...
Gordon W. Blair, M. Thrippleton, Yulu Shi, I. Hamilton, M. Stringer, F. Chappell, D. A. Dickie, P. Andrews, I. Marshall, F. Doubal, J. Wardlaw   +10 more
semanticscholar   +1 more source

Arterial branching and basal ganglia lacunes: a study in pure small vessel disease [PDF]

, 2017
Introduction: Lacunes are defined morphologically by size and location, but radiological characteristics alone may be unable to distinguish small vessel disease aetiology from alternative mechanisms.
Beare, Richard, Chabriat, Hugues, Dichgans, Martin, Düring, Marco, Huang, Xuya, Jouvent, Eric, Moreton, Fiona C., Muir, Keith W., Phan, Thanh, Srikanth, Velandai   +9 more
core   +2 more sources