Results 141 to 150 of about 198,856 (347)

AXL Promotes Ischemic Myelin Repair Through Alleviating Myelin Debris Deposition and Lipid Droplets Accumulation

Advanced Science, EarlyView.
Microglial AXL drives white matter repair after stroke by orchestrating the cleanup of myelin debris. Mechanistically, AXL signals through EGR1 to boost Smpd1 transcription, regulating sphingolipid metabolism and preventing lipid droplet toxicity. Restoring the pathway with ASM therapy mitigates damage, positioning AXL as a key node for therapeutic ...
Junqiu Jia, Yonghui Gan, Jia Li, Lilin Li, Hailan Meng, Min Sun, Lei Ye, Rui Mao, Xiang Cao, Shengnan Xia, Xinyu Bao, Renyuan Liu, Meijuan Zhang, Yun Xu   +13 more
wiley   +1 more source

Through Skull Fluorescence Imaging of the Brain in a New Near-Infrared Window

, 2014
To date, brain imaging has largely relied on X-ray computed tomography and magnetic resonance angiography with limited spatial resolution and long scanning times.
Andreasson, Katrin I., Antaris, Alexander L., Atochin, Dmitriy N., Chang, Junlei, Chen, Changxin, Dai, Hongjie, Diao, Shuo, Hong, Guosong, Huang, Paul L., Kuo, Calvin J., Zhang, Bo, Zhao, Su   +11 more
core   +2 more sources

Association betweenHelicobacter pyloriInfection and Cerebral Small Vessel Disease [PDF]

, 2015
Soo Hyun Jang, Hye-Jin Lee, Jun Suk Kim, Hyun-Jung Park, Su Min Jeong, Sang‐Hyun Lee, Hyun Ho Kim, Jin‐Ho Park, Dong Wook Shin, Jae Moon Yun, Belong Cho, Hyung‐Min Kwon   +11 more
openalex   +1 more source

Gram‐Scale Synthesis of Hafnium‐Rich Carbon Dots for Preclinical Computed Tomography Imaging Across Various Systems

Advanced Science, EarlyView.
Hafnium (Hf)‐rich carbon dots (Hf‐rCDs) with high metal content (40.7%) and robust batch production capacity (>2 g per batch) are synthesized via a facile air‐assisted pyrolysis method. In vivo CT imaging demonstrates outstanding performance of Hf‐rCDs across multiple physiological systems and enables high‐resolution visualization of swine cervical ...
Shuo Li, Hengrui Wu, Jianqi Deng, Qiyu Sun, Yuping Zhang, Cai Zhang, Jinbin Pan, Dingbin Liu, Xuejun Zhang, Quan Zou, Xiaoyuan Chen, Shao‐Kai Sun   +11 more
wiley   +1 more source

Attenuated inflammatory profile following single and repeated handgrip exercise and remote ischemic preconditioning in patients with cerebral small vessel disease [PDF]

, 2022
Thijs Landman, Laween Uthman, Inge A. H. Hofmans, Yvonne Schoon, Frank‐Erik de Leeuw, Dick H. J. Thijssen   +5 more
openalex   +1 more source

Cytokine‐Engineered Chimeric Antigen Receptor‐T Cell Therapy: How to Balance the Efficacy and Toxicity

Advanced Science, EarlyView.
Cytokine‐engineered CAR‐T cells represent a promising immunotherapy against malignancies due to direct tumor killing and potent immunity response. However, significant toxicities, including CRS and ICANS, have restricted clinical applications. How to keep the risk‐benefit balance of the advanced therapy is of great importance for maximizing the benefit
Xinru Zhang, Gulizeba Aimaiti, Yuanye Guan, Yuzhe Sha, Wei Zhou, Jiefeng Shen, Bo Zhao, Wei‐En Yuan   +7 more
wiley   +1 more source

Small‐Vessel Disease and Intracranial Large Artery Disease in Brain MRI Predict Dementia and Acute Coronary Syndrome, Respectively: A Prospective, Observational Study in the Population at High Vascular Risk

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background We aimed to clarify the predictive value of cerebral small‐vessel disease and intracranial large artery disease (LAD) observed in magnetic resonance imaging of the brain and magnetic resonance angiography on future vascular events and ...
Kazuo Kitagawa, Sono Toi, Megumi Hosoya, Hiroshi Yoshizawa   +3 more
doaj   +1 more source

Amelioration of Post‐Stroke Edema and Microcirculatory Dysfunction via Targeted AQP4 Inhibition While Preserving the Glymphatic System

Advanced Science, EarlyView.
Compared to untargeted therapy, the targeted nanocarrier, Angiopep‐2‐conjugated Lipid Nanoparticle (A‐LNP) loaded with TGN‐020 (TGN), selectively accumulated in stroke‐injured regions. It suppressed local aquaporin‐4 (AQP4) overexpression, thereby alleviating cerebral edema and hypoperfusion while preserving global glymphatic clearance.
Lei Jin, Zeyu Yang, Boyang Wei, Yu Wu, Longxiang Li, Jiaming Zhou, Xin Zhang, Fa Jin, Shixing Su, Yanchao Liu, Ran Li, Shenquan Guo, Xingwu Liu, Yu Cai, Hong Liu, Min Chen, Wenchao Liu, Chuanzhi Duan, Xifeng Li   +18 more
wiley   +1 more source

Emerging Evidence for Pathogenesis of Sporadic Cerebral Small Vessel Disease [PDF]

, 2016
Masafumi Ihara, Yumi Yamamoto
openalex   +1 more source

Segmentation of Cerebral Small Vessel Diseases-White Matter Hyperintensities Based on a Deep Learning System

, 2021
Wei Shan, Yunyun Duan, Yu Zheng, Zhenhua Wu, Wei Sheng Chan, Qun Wang, Peiyi Gao, Yaou Liu, Kunlun He, Yongjun Wang   +9 more
openalex   +1 more source