Results 141 to 150 of about 211,077 (381)

Identification of Schwann Cells in Human Intracranial Arteries: Potential Regulatory Role in Atherosclerotic Plaque Progression

Advanced Science, EarlyView.
Schwann cells may facilitate intracranial plaque progression via neurovascular remodelingcting with vascular smooth muscle cells in atherosclerotic plaques, with the SPP1 ‐ ITGB1 signaling axis mediating this interaction as a novel mechanism. Abstract Intracranial atherosclerosis (ICAS), a common cause of ischemic stroke, remains a therapeutic ...
Zijue Wang, Yangzhige He, Weizhuang Yuan, Yijun Xia, Manqiu Ding, Zhen Chen, Naili Wang, Chao Ma, Xiaoyue Wang, Yan Xu, Weihai Xu   +10 more
wiley   +1 more source

Genetics of Cerebral Small Vessel Disease [PDF]

Stroke, 2020
Christopher D. Anderson, Sandro Marini, Jonathan Rosand   +2 more
openaire   +2 more sources

Artificial Intelligent‐Enhanced Metabolite Profiling for Intraoperative IDH1 Genotyping in Glioma Using an Orthogonally Responsive SERS Probe

Advanced Science, EarlyView.
This study presents a novel approach for intraoperative identification of the IDH1 genotype in glioma patients using a surface‐enhanced Raman scattering (SERS) probe to measure glutathione and hydrogen peroxide. By integrating AI‐driven deep learning algorithms, the method achieves rapid and accurate genotype differentiation, offering the potential to ...
Hang Yin, Xin Zhang, Zheng Zhao, Chong Cao, Minhua Xu, Suhongrui Zhou, Tian Xuan, Ziyi Jin, Limei Han, Yang Fan, Cong Wang, Xiao Zhu, Ying Mao, Jinhua Yu, Cong Li   +14 more
wiley   +1 more source

Carotid Atherosclerotic Markers in CADASIL [PDF]

, 2011
Purpose: Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a cerebral small vessel disease caused by mutations of the NOTCH3 gene. Marked variations in disease severity have raised the hypothesis that
Aout, Mounir, Chabriat, Hugues, Dichgans, Martin, Düring, Marco, Mawet, Jerome, Touboul, Pierre Jean, Vahedi, Katayoun, Vicaut, Eric   +7 more
core   +1 more source

DNase I‐Mediated Chemotactic Nanoparticles for NETs Targeting and Microenvironment Remodeling Treatment of Acute Ischemic Stroke

Advanced Science, EarlyView.
The neutrophil extracellular traps (NETs) play an important role in reperfusion injury in ischemic stroke. Here, considering the unique vascular localization of NETs, a DNase I‐mediated NETs‐targeting nanoparticle is developed to integrate the catalytic and chemotactic functions of DNase I and achieve the synergistic regulation of the internal and ...
Tongyu Zhang, Peixin Liu, Wenru Shen, Chao Li, Zhenhao Zhao, Yuxing Wu, Tao Sun, Chen Jiang   +7 more
wiley   +1 more source

Accelerated development of cerebral small vessel disease in young stroke patients. [PDF]

, 2016
OBJECTIVE: To study the long-term prevalence of small vessel disease after young stroke and to compare this to healthy controls. METHODS: This prospective cohort study comprises 337 patients with an ischemic stroke or TIA, aged 18-50 years, without a ...
Arntz, Renate M, de Leeuw, Frank-Erik, Ghafoorian, Mohsen, Maaijwee, Noortje AM, Platel, Bram, Rutten-Jacobs, Loes CA, Schaapsmeerders, Pauline, Schoonderwaldt, Hennie C, van den Broek, Steffen MA, van Dijk, Ewoud J, van Uden, Inge WM   +10 more
core   +2 more sources

Neutrophil Mobilization Triggers Microglial Functional Change to Exacerbate Cerebral Ischemia‐Reperfusion Injury

Advanced Science, EarlyView.
These study underscores the pivotal role of neutrophil‐derived myeloid‐related protein 14 (MRP14) in the pathophysiology of acute ischemic stroke (AIS). MRP14 not only disrupts mitochondrial function, thereby inhibiting microglial phagocytosis of neutrophils, but also activates microglial pyroptosis, exacerbating neuroinflammation following AIS ...
Huijuan Jin, Zhifang Li, Senwei Tan, Qinghui Xiao, Qingcan Li, Jiao Ye, Yifan Zhou, Yan Wan, Qiang Liu, Bijoy K Menon, Bo Hu   +10 more
wiley   +1 more source

Pericyte-mediated regulation of capillary diameter: a component of neurovascular coupling in health and disease [PDF]

, 2010
Because regional blood flow increases in association with the increased metabolic demand generated by localised increases in neural activity, functional imaging researchers often assume that changes in blood flow are an accurate read-out of changes in ...
Attwell, D., Hall, C.N., Hamilton, N.B.
core   +3 more sources

A Novel Cranial Bone Transport Technique Repairs Skull Defect and Minimizes Brain Injury Outcome in Traumatic Brain Injury Rats

Advanced Science, EarlyView.
This study introduces a novel, safe, and effective surgical technique: Cranial bone transport (CBT) to improve traumatic brain injury (TBI) outcomes in rats. CBT significantly accelerated skull defect bone repair in addition to its promoting effects on neurological function recovery. This work provides an alternative therapy for patients suffering from
Shanshan Bai, Xuan Lu, Xu Yan, Han Su, Yuejun Lin, Zhaowei Jiang, Zhixian Zong, Haixing Wang, Leo Yik Chun Yan, Xiaoting Zhang, Ming Wang, Zhengmeng Yang, Jiakang Jin, Yaofeng Wang, Wayne Yuk‐Wai Lee, Xiaohua Jiang, Ho Ko, Lu Feng, Micky D. Tortorella, Sien Lin, Gang Li   +20 more
wiley   +1 more source

Wireless In Situ Catalytic Electron Signaling‐Mediated Transcriptomic Reprogramming for Neuron Regeneration via Adaptable Antennas

Advanced Science, EarlyView.
A wireless‐charging sustained oxygen release from conductive microgels (SOCO) served as an antenna and an on‐demand O2 release for nerve regeneration is developed. Introducing “electromagnetic messenger”, using external alternating magnetic field (AMF) to enhance catalytic oxygen release and electrical stimulation to promote the reconstruction of blood
Hoi Man Iao, Chih‐Ying Chen, Ya‐Hui Lin, Wan‐Chi Pan, Chun‐Yi Liang, Hsiu‐Ching Liu, Lo‐Jei Ching, Pei‐Yu Weng, Min‐Ren Chiang, Ru‐Siou Hsu, Tsu‐Chin Chou, I‐Chi Lee, Lun‐De Liao, Li‐An Chu, Shih‐Hwa Chiou, Shang‐Hsiu Hu   +15 more
wiley   +1 more source