ABSTRACT Mild behavioral impairment (MBI) is a late‐life neuropsychiatric syndrome proposed as an early clinical manifestation of neurodegenerative disease. Vascular pathology contributes to late‐life cognitive and behavioral changes; however, its relationship with MBI remains insufficiently characterized.
Po‐Han Chen +6 more
wiley +1 more source
Diffusion kurtosis imaging (gen)omics unravels mechanisms of cerebral small vessel disease
Le Grand Q +7 more
europepmc +1 more source
Orbital Lymphatic Malformations Are Associated With Intracranial Vascular Anomalies
In this retrospective series, all seven patients with orbital lymphatic malformations had intracranial vascular anomalies consistent with cerebrofacial venous metameric syndrome and hotspot PIK3CA variants identified through tissue‐based sequencing. Five patients treated with alpelisib experienced symptom improvement within 6 months.
Kelsey A. Loy +11 more
wiley +1 more source
Astrocyte-blood-brain barrier crosstalk in cerebral small vessel disease: linking barrier dysfunction to neurovascular failure. [PDF]
Xie M, Wu S, Yang L, Zhang Y.
europepmc +1 more source
JAK2 Variant and Parkinsonian Syndromes: Coincidence or Pathophysiological Link?
Abstract Background JAK2 variants are a hallmark of myeloproliferative neoplasms (MPNs), including polycythemia vera and essential thrombocythemia. These disorders are often associated with thrombotic and inflammatory complications. From a movement disorder perspective, chorea is a rare but well‐recognized neurological occurrence in this context ...
Elena Ardila Jurado +5 more
wiley +1 more source
Association of total cerebral small vessel disease burden with left ventricular hypertrophy and geometry in patients with ischemic stroke. [PDF]
Li X +6 more
europepmc +1 more source
Lewy Body Disease Across Aging: Clinical and Neuropathological Correlates in a Population Brain Bank
Abstract Background Lewy body disease (LBD) is defined by neuronal α‐synuclein pathology, but how Braak‐staged LBD relates to mixed neuropathology and clinical manifestations within a single population‐based cohort remains incompletely characterized. This is especially relevant in cohorts enriched for younger individuals, which may better inform real ...
Vitor Ribeiro Paes +13 more
wiley +1 more source
Correction: Perivascular diffusion and white matter free water improve identification of cognitive impairment in cerebral small vessel disease. [PDF]
Yang C +10 more
europepmc +1 more source
ABSTRACT Purpose To develop an efficient dynamic pseudo‐continuous arterial spin labeling (pCASL) MRI technique for whole‐brain microvascular flow pulsatility imaging. Methods The proposed technique combines pCASL with a segmented stack‐of‐stars golden‐angle radial acquisition.
Tianrui Zhao +5 more
wiley +1 more source

