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Exploring cerebral small vessel disease signatures in familial Parkinson’s disease [PDF]

Scientific Reports
Familial Parkinson’s disease (PD) and vascular parkinsonism (VP) present overlapping features and may co-exist. To investigate whether PD and VP may share a potential pathogenic link and to what extent white matter hyperintensities may influence PD ...
Bigyan Mahat, Bimala Malla, Marco Foddis, Dieter Beule, Jose Bras, Rita Guerreiro, Vasilis Kola, Hans-Michael Schmitt, Matthias Endres, Celeste Sassi   +9 more
doaj   +2 more sources

Choroid Plexus Enlargement and USPIO-Based Inflammatory Feature in Cerebral Small Vessel Disease. [PDF]

Ann Clin Transl Neurol
ABSTRACT Objective The choroid plexus (CP) is a key component of the blood–cerebrospinal fluid barrier (BCSFB), but its mechanism of action in cerebral small vessel disease (CSVD) remains unclear. This study investigated CP volume (CPV) alterations and their association with conventional imaging markers in CSVD and explored the underlying role of ...
Qu Y, Ren X, Fan C, Li C, Zhang L, Zhang Z, Li S, Lai Z, Cai B, Fu Y, Lin Y, Zhu Z.   +11 more
europepmc   +2 more sources

Genetics of Cerebral Small Vessel Disease [PDF]

Journal of Stroke, 2015
Cerebral small vessel disease (SVD) is an important cause of stroke and cognitive impairment among the elderly and is a more frequent cause of stroke in Asia than in the US or Europe.
Jay Chol Choi
doaj   +1 more source

Small-vessel disease in the brain

American Heart Journal Plus, 2023
Cerebral small-vessels are generally located in the brain at branch points from major cerebral blood vessels and perfuse subcortical structures such as the white matter tracts, basal ganglia, thalamus, and pons.
Amita Singh, Gabriel Bonnell, Justin De Prey, Natalie Buchwald, Kyrillos Eskander, Keith J. Kincaid, Christina A. Wilson   +6 more
doaj   +1 more source

Cerebral Small Vessel Disease and Chronic Kidney Disease [PDF]

Journal of Stroke, 2015
Chronic kidney disease, defined by a decreased glomerular filtration rate or albuminuria, is recognized as a major global health burden, mainly because it is an established risk factor for cardiovascular and cerebrovascular diseases. The magnitude of the
Kazunori Toyoda
doaj   +1 more source

Small Vessel Disease

Frontiers in Neurology, 2019
Small vessel disease (SVD) refers to conditions where damage to arterioles and capillaries is predominant, leading to reduced, or interrupted perfusion of the affected organ.
Antoine M. Hakim, Antoine M. Hakim, Antoine M. Hakim   +2 more
doaj   +1 more source

HTRA1-related autosomal dominant cerebral small vessel disease

Chinese Medical Journal, 2021
. Background. Homozygous or compound heterozygous mutations in high temperature requirement serine peptidase A1 (HTRA1) gene are responsible for cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy (CARASIL ...
Jing-Yi Liu, Yi-Cheng Zhu, Li-Xin Zhou, Yan-Ping Wei, Chen-Hui Mao, Li-Ying Cui, Bin Peng, Ming Yao, Xin Chen   +8 more
doaj   +1 more source

Cerebral Small Vessel Disease

Cell Transplantation, 2018
Cerebral small vessel disease (CSVD) is composed of several diseases affecting the small arteries, arterioles, venules, and capillaries of the brain, and refers to several pathological processes and etiologies.
Qian Li, Yang Yang, Cesar Reis, Tao Tao, Wanwei Li, Xiaogang Li, John H. Zhang   +6 more
doaj   +1 more source

Proteostasis in Cerebral Small Vessel Disease

Frontiers in Neuroscience, 2019
Maintaining the homeostasis of proteins (proteostasis) by controlling their synthesis, folding and degradation is a central task of cells and tissues. The gradual decline of the capacity of the various proteostasis machineries, frequently in combination ...
Christof Haffner
doaj   +1 more source

Hypercholesterolemia induced cerebral small vessel disease.

PLoS ONE, 2017
BackgroundWhile hypercholesterolemia plays a causative role for the development of ischemic stroke in large vessels, its significance for cerebral small vessel disease (CSVD) remains unclear.
Peter Kraft, Michael K Schuhmann, Cornelia Garz, Solveig Jandke, Daniela Urlaub, Stine Mencl, Alma Zernecke, Hans-Jochen Heinze, Roxana O Carare, Christoph Kleinschnitz, Stefanie Schreiber   +10 more
doaj   +1 more source