Results 31 to 40 of about 362,333 (255)

How diet affects Alzheimer's disease and small vessel disease

Lifestyle Medicine, 2022
Introduction The number of people with memory disorders is increasing worldwide. Changing certain lifestyle factors can prevent the development of those disorders. Diet is a central factor that can be changed.
Juha Lempiäinen
doaj   +1 more source

Integration of Genome‐Wide Association Studies With Single‐Cell and Bulk Expression Quantitative Trait Locus to Identify Stroke Susceptibility Genes

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Previous studies have integrated genome‐wide association studies with expression quantitative trait locus (eQTL) data from bulk tissues to identify stroke susceptibility genes. However, eQTL data exhibit high cell‐type specificity, and genetic
Yijie He, Tao Zhang, Ping Zhu, Shan Gao, Shiyang Wu, Fengzhen Liu, Yan Chen, Yingshui Yao, Guiyou Liu   +8 more
doaj   +1 more source

Dawson's Fingers in Cerebral Small Vessel Disease

Frontiers in Neurology, 2020
To explore Dawson's fingers in cerebral small vessel disease (CSVD) and factors related to the development of Dawson's finger, we collected and analyzed clinical data of 65 patients with CSVD. We found a venous abnormality feature called Dawson's fingers
Aowei Lv, Zaiqiang Zhang, Ying Fu, Yaping Yan, Li Yang, Wenli Zhu   +5 more
doaj   +1 more source

Small Vessel Disease: Neuropathology

International Psychogeriatrics, 2003
Diseases of small cerebral blood vessels are heterogeneous in etiology and manifestations. Lipohyalinosis, venous collagenosis, amyloid angiopathy, and CADASIL affect different populations of blood vessels. Large and small hemorrhages, lacunae, cortical microinfarcts, and leukoaraiosis are the most important consequences of the small vessel ...
openaire   +2 more sources

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Surface-based morphometry of the cerebral cortex in cognitive impairments of varying severity in patients with age-related cerebral small vessel disease [PDF]

Digital Diagnostics
BACKGROUND: Analysis of structural magnetic resonance images is essential to assessing the main substrate of cognitive impairment in sporadic age-related cerebral small vessel disease, accounting for up to 45% of all dementia cases.
Elena I. Kremneva, Larisa A. Dobrynina, Kamila V. Shamtieva, Victoria V. Trubitsyna, Zukhra S. Gadzhieva, Angelina G. Makarova, Maria M. Tsypushtanova, Marina V. Krotenkova   +7 more
doaj   +1 more source

Potential biomarkers of Alzheimer’s disease and cerebral small vessel disease

Frontiers in Molecular Neuroscience, 2022
BackgroundCerebral small vessel disease (CSVD) is associated with the pathogenesis of Alzheimer’s disease (AD). Effective treatments to alleviate AD are still not currently available.
Chun Zou, Xiaohua Huang, Yilong Zhang, Mika Pan, Jieqiong Xie, Liechun Chen, Youshi Meng, Donghua Zou, Donghua Zou, Jiefeng Luo   +9 more
doaj   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Total magnetic resonance imaging of cerebral small vessel disease burden predicts dysphagia in patients with a single recent small subcortical infarct

BMC Neurology, 2022
Background This study was performed to identify the association between the total magnetic resonance imaging burden of small vessel disease and the occurrence of post-stroke dysphagia in patients with a single recent small subcortical infarct (RSSI ...
Lulu Zhang, Xiang Tang, Yidan Li, Juehua Zhu, Dongxue Ding, Yun Zhou, Shanshan Diao, Yan Kong, Xiuying Cai, Ye Yao, Qi Fang   +10 more
doaj   +1 more source