Results 41 to 50 of about 10,358,075 (261)

Research progress of impaired cerebral hemodynamics in cerebral small vessel disease

Chinese Journal of Contemporary Neurology and Neurosurgery, 2021
Cerebral hemodynamic damage is an important mechanism in the pathogenesis of arteriolosclerotic cerebral small vessel disease (CSVD). The hemodynamic damage of cerebral small vessel disease includes the changes of blood pressure variability (BPV ...
LIU Na, XUE Yang, TANG Jie, ZHANG Miao⁃yi, REN Xue , FU Jian⁃hui   +5 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Gene-mapping study of extremes of cerebral small vessel disease reveals TRIM47 as a strong candidate [PDF]

, 2022
Cerebral small vessel disease is a leading cause of stroke and a major contributor to cognitive decline and dementia, but our understanding of specific genes underlying the cause of sporadic cerebral small vessel disease is limited.
Debette, Stephanie, Psaty, Bruce M., Weiss, Stefan, Gudnason, Vilmundur, Rotter, Jerome I, Yang, Qiong, Tzourio, Christophe, Fornage, Myriam, Bülow, Robin, Jian, Xueqiu, Vojinovic, Dina, Duplaà, Cécile, Kardia, Sharon LR, Gottesman, Rebecca F., Vernooij, Meike W, SMITH, Jennifer A., Boerwinkle, Erik, Kardia, Sharon L R, Ikram, M. Arfan, Grabe, Hans J, Hofer, Edith, Bis, Joshua C, DeCarli, Charles S, MUNOZ MANIEGA, Susana, Lathrop, Mark, ROTTER, Jerome I., Harris, Sarah E, Gottesman, Rebecca F, Schmidt, Helena, Gampawar, Piyush G., KNOPMAN, David S., Lopez, Oscar L, Beiser, Alexa S., Zilhão, Nuno R, van der Auwera-Palitschka, Sandra, Bastin, Mark E., Luciano, Michelle, Bastin, Mark E, Zhao, Wei, Deary, Ian J, Psaty, Bruce M, Matthews, Paul M, Joutel, Anne, Li, Shuo, Launer, Lenore J, Decarli, Charles S., Ihara, Masafumi, Schmidt, Reinhold, Kardia, Sharon L.R., Adams, Hieab H H, Wittfeld, Katharina, Dufouil, Carole, Gampawar, Piyush G, Adams, Hieab H.H., Lopez, Oscar L., Muñoz Maniega, Susana; id_orcid, Valdés Hernández, Maria, Mosley, Thomas H., Beiser, Alexa S, Kacprowski, Tim, Longstreth, William T., Morris, Zoe, Satizabal, Claudia L, Bartz, Traci M, Völker, Uwe, Zhu, Yicheng, Longstreth, William T, Vernooij, Meike W., Sargurupremraj, Muralidharan, Suzuki, Hideaki, Adams, Hieab HH, Vernooij, Meike W.; id_orcid, Grabe, Hans J., Wardlaw, Joanna M., Knopman, David S, Mosley, Thomas H, Deary, Ian J., Maniega, Susana Muñoz, Couffinhal, Thierry, Harris, Sarah E., ZILHAO, Nuno R., Amouyel, Philippe, Mazoyer, Bernard, Mishra, Aniket, Yu, Miao, van Duijn, Cornelia M, Bis, Joshua C., Ikram, M Arfan, Bartz, Traci M., Seshadri, Sudha, Launer, Lenore J., Satizabal, Claudia L., Wardlaw, Joanna M, Matthews, Paul M., Teumer, Alexander, Smith, Jennifer A, Van Duijn, Cornelia M., Tournier-Lasserve, Elizabeth, Hernández, Maria Valdés, Soumare, Aicha   +99 more
core   +2 more sources

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Blood-brain barrier leakage hotspots collocating with brain lesions due to sporadic and monogenic small vessel disease [PDF]

, 2023
Blood-brain barrier (BBB) is known to be impaired in cerebral small vessel disease (SVD), and is measurable by dynamic-contrast enhancement (DCE)-MRI.
Ingrisch, Michael, Duering, M., Salvatore Rudilosso, Hamilton, I., Blair, Gordon W, Ingrisch, M., Wardlaw, J.M., Janssen, Esther, Chappell, F., Francesca Chappell, Michael S Stringer, Thrippleton, M., Janssen, E., Joanna M Wardlaw, Michael Thrippleton, Thrippleton, Michael; id_orcid, Michael Ingrisch, Stringer, M.S., Martin Dichgans, Walter H Backes, Daniela Jaime Garcia, Esther Janssen, Hamilton, Iona, Iona Hamilton, Stringer, Michael S, Kopczak, Anna, Backes, W.H., Duering, Marco, Gordon W Blair, Rudilosso, Salvatore, Rudilosso, S., Kerkhofs, Danielle, Fergus Doubal, Marco Duering, Staals, Julie, Thrippleton, Michael, Staals, J., Doubal, Fergus, Anna Kopczak, Julie Staals, Backes, Walter H, Danielle Kerkhofs, Kopczak, A., Garcia, D.J., Blair, G.W., Jaime garcia, Daniela, Dichgans, Martin, Wardlaw, Joanna M, Chappell, Francesca, Doubal, F., Dichgans, M., Kerkhofs, D.   +51 more
core   +1 more source

Cerebral small vessel disease and cognitive impairment

Journal of Neurorestoratology, 2019
Cerebral small vessel disease (CSVD) is a pathophysiological process involving small arteries such as cerebellar arteries, arterioles, capillaries, and veinlets.
Lifang Meng, Jianhua Zhao, Junli Liu, Shaomin Li   +3 more
doaj   +1 more source

Total magnetic resonance imaging of cerebral small vessel disease burden predicts dysphagia in patients with a single recent small subcortical infarct

BMC Neurology, 2022
Background This study was performed to identify the association between the total magnetic resonance imaging burden of small vessel disease and the occurrence of post-stroke dysphagia in patients with a single recent small subcortical infarct (RSSI ...
Lulu Zhang, Xiang Tang, Yidan Li, Juehua Zhu, Dongxue Ding, Yun Zhou, Shanshan Diao, Yan Kong, Xiuying Cai, Ye Yao, Qi Fang   +10 more
doaj   +1 more source

Potential biomarkers of Alzheimer’s disease and cerebral small vessel disease

Frontiers in Molecular Neuroscience, 2022
BackgroundCerebral small vessel disease (CSVD) is associated with the pathogenesis of Alzheimer’s disease (AD). Effective treatments to alleviate AD are still not currently available.
Chun Zou, Xiaohua Huang, Yilong Zhang, Mika Pan, Jieqiong Xie, Liechun Chen, Youshi Meng, Donghua Zou, Donghua Zou, Jiefeng Luo   +9 more
doaj   +1 more source