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Genetic considerations in cerebral small vessel diseases [PDF]

Frontiers in Neurology, 2023
Cerebral small vessel disease (CSVD) encompasses a broad clinical spectrum united by pathology of the small vessels of the brain. CSVD is commonly identified using brain magnetic resonance imaging with well characterized markers including covert infarcts,
Riwaj Bhagat, Sandro Marini, José R. Romero, José R. Romero   +3 more
doaj   +6 more sources

Zooming in on cerebral small vessel function in small vessel diseases with 7T MRI: Rationale and design of the “ZOOM@SVDs” study [PDF]

Cerebral Circulation - Cognition and Behavior, 2021
Background: Cerebral small vessel diseases (SVDs) are a major cause of stroke and dementia. Yet, specific treatment strategies are lacking in part because of a limited understanding of the underlying disease processes.
Hilde van den Brink, Anna Kopczak, Tine Arts, Laurien Onkenhout, Jeroen C.W. Siero, Jaco J.M. Zwanenburg, Marco Duering, Gordon W. Blair, Fergus N. Doubal, Michael S. Stringer, Michael J. Thrippleton, Hugo J. Kuijf, Alberto de Luca, Jeroen Hendrikse, Joanna M. Wardlaw, Martin Dichgans, Geert Jan Biessels   +16 more
doaj   +4 more sources

Cerebral Small Vessel Disease [PDF]

International Journal of Molecular Sciences, 2020
Cerebral small vessel disease (CSVD) represents a cluster of various vascular disorders with different pathological backgrounds. The advanced vasculature net of cerebral vessels, including small arteries, capillaries, arterioles and venules, is usually affected. Processes of oxidation underlie the pathology of CSVD, promoting the degenerative status of
Jakub Litak, Marek Mazurek, Bartłomiej Kulesza, Paweł Szmygin, Joanna Litak, Piotr Kamieniak, Cezary Grochowski   +6 more
core   +9 more sources

Brain atrophy in cerebral small vessel diseases: Extent, consequences, technical limitations and perspectives: The HARNESS initiative [PDF]

Journal of Cerebral Blood Flow and Metabolism, 2020
Brain atrophy is increasingly evaluated in cerebral small vessel diseases. We aim at systematically reviewing the available data regarding its extent, correlates and cognitive consequences.
François De Guio, Marco Duering, Franz Fazekas   +2 more
exaly   +4 more sources

Essential nutrients and cerebral small vessel diseases: a two-sample Mendelian randomization study [PDF]

Frontiers in Nutrition, 2023
BackgroundPrevious studies have suggested a potential association between nutrients and cerebral small vessel disease (CSVD), but this association has not been fully addressed.ObjectWe intended to clarify the causal associations between four categories ...
Jiayi Li, Jiayi Li, Kailin Xia, Zhengrui Wang, Zhengrui Wang, Yanru Liu, Yanru Liu, Yicheng Tong, Yicheng Tong, Yuwei Wang, Yuwei Wang, Yumou Zhou, Yumou Zhou, Linjing Zhang, Linjing Zhang, Linjing Zhang, Lu Tang, Lu Tang, Lu Tang, Dongsheng Fan, Dongsheng Fan, Dongsheng Fan, Qiong Yang   +22 more
doaj   +2 more sources

Prevalence and Consequences of Cerebral Small Vessel Diseases: A Cross-Sectional Study Based on Community People Plotted Against 5-Year Age Strata [PDF]

Neuropsychiatric Disease and Treatment, 2022
Ronghua Mu,1,2,* Xiaoyan Qin,2,* Zixuan Guo,1,2,* Zhuoni Meng,1,2 Fuzhen Liu,2 Zeyu Zhuang,1,2 Wei Zheng,1,2 Xin Li,2 Peng Yang,2 Yuling Feng,2 Yanchun Jiang,3 Xiqi Zhu2 1Graduate School of Guilin Medical University, Guilin, 541004, People’s ...
Mu R, Qin X, Guo Z, Meng Z, Liu F, Zhuang Z, Zheng W, Li X, Yang P, Feng Y, Jiang Y, Zhu X   +11 more
doaj   +2 more sources

Segmentation of incident lacunes during the course of ischemic cerebral small vessel diseases [PDF]

Frontiers in Neurology, 2023
BackgroundLacunes represent key imaging markers of cerebral small vessel diseases (cSVDs). During their progression, incident lacunes are related to stroke manifestations and contribute to progressive cognitive and/or motor decline. Assessing new lesions
Jessica Lebenberg, Jessica Lebenberg, Ruiting Zhang, Ruiting Zhang, Lina Grosset, Lina Grosset, Lina Grosset, Jean Pierre Guichard, Fanny Fernandes, Eric Jouvent, Eric Jouvent, Eric Jouvent, Hugues Chabriat, Hugues Chabriat, Hugues Chabriat   +14 more
doaj   +2 more sources

Genetics of common cerebral small vessel disease [PDF]

Nature Reviews Neurology, 2022
Cerebral small vessel disease (cSVD) is a leading cause of ischaemic and haemorrhagic stroke and a major contributor to dementia. Covert cSVD, which is detectable with brain MRI but does not manifest as clinical stroke, is highly prevalent in the general population, particularly with increasing age.
Constance Bordes, Muralidharan Sargurupremraj, Aniket Mishra, Stéphanie Debette   +3 more
openaire   +3 more sources

Hereditary cerebral small vessel diseases: A review

Journal of the Neurological Sciences, 2012
Cerebral microangiopathies are responsible of a great number of strokes. In the recent years advances in molecular genetics identified several monogenic conditions involving cerebral small vessels and predisposing to ischemic and/or hemorrhagic stroke and diffuse white matter disease leading to vascular dementia.
FEDERICO, ANTONIO, DI DONATO, ILARIA, BIANCHI, SILVIA, Di Palma C, Taglia I, DOTTI, MARIA   +5 more
openaire   +4 more sources

Blood urea nitrogen to albumin ratio is associated with cerebral small vessel diseases [PDF]

Scientific Reports
Blood urea nitrogen (BUN) to albumin ratio (BAR) is a comprehensive parameter that reflects renal, inflammatory, nutritional, and endothelial functions.
Ki-Woong Nam, Hyung-Min Kwon, Han-Yeong Jeong, Jin-Ho Park, Kyungha Min   +4 more
doaj   +2 more sources