Results 31 to 40 of about 8,233,957 (244)

Cerebral Venous Reflux and Dilated Basal Ganglia Perivascular Space in Hypertensive Intracerebral Hemorrhage [PDF]

Journal of Stroke, 2022
Background and Purpose Cerebral venous flow alterations potentially contribute to age-related white matter changes, but their role in small vessel disease has not been investigated. Methods This study included 297 patients with hypertensive intracerebral
Hsin-Hsi Tsai, Bo-Ching Lee, Ya-Fang Chen, Jiann-Shing Jeng, Li-Kai Tsai   +4 more
doaj   +1 more source

Brain MRI in Monogenic Cerebral Small Vessel Diseases: A Practical Handbook

, 2022
Monogenic cerebral small vessel diseases are a topic of growing interest, as several genes responsible have been recently described, and new sequencing techniques such as Next-generation sequencing are available.
Giannini, Nicola, Ulivi, Leonardo, Siciliano, Gabriele, Migaleddu, Gianmichele, Cosottini, Mirco, Orlandi, Giovanni, Mancuso, Michelangelo, Nicola Giannini, Michelangelo Mancuso, Mirco Cosottini, Gabriele Siciliano, Gianmichele Migaleddu, Giovanni Orlandi, Leonardo Ulivi   +13 more
core   +1 more source

A novel COL4A1 variant associated with recurrent epistaxis and glioblastoma

Human Genome Variation, 2021
COL4A1-related disorders are characterized by a higher incidence of cerebral hemorrhage than other hereditary cerebral small vessel diseases. Accumulating data have shown broad phenotypic variations, and extracerebral hemorrhages have been linked to ...
Kohei Muto, Ryosuke Miyamoto, Yuka Terasawa, Yoshimitsu Shimatani, Keijiro Hara, Takumi Kakimoto, Tatsuya Fukumoto, Yusuke Osaki, Koji Fujita, Masafumi Harada, Hisanori Uehara, Yasushi Takagi, Yuishin Izumi   +12 more
doaj   +1 more source

Cerebral Small Vessel Disease and Alzheimer's Disease: A Review

Frontiers in Neurology, 2020
Alzheimer's disease (AD) is the most common cause of dementia. Despite this, clear pathophysiology for AD has not been confirmed, and effective treatments are still not available.
Hae Won Kim, Jeongho Hong, Jae Cheon Jeon   +2 more
doaj   +1 more source

Depression in small-vessel disease relates to white matter ultrastructural damage, not disability. [PDF]

, 2014
OBJECTIVE: To determine whether cerebral small-vessel disease (SVD) is a specific risk factor for depression, whether any association is mediated via white matter damage, and to study the role of depressive symptoms and disability on quality of life (QoL)
Morris, RG, Brookes, RL, Lawrence, AJ, Morris, Robin G., Lawrence, Andrew J.; id_orcid, Herbert, Vanessa, Herbert, V, Brookes, Rebecca L., Markus, Hugh S., Markus, HS   +9 more
core   +1 more source

Integration of Genome‐Wide Association Studies With Single‐Cell and Bulk Expression Quantitative Trait Locus to Identify Stroke Susceptibility Genes

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Previous studies have integrated genome‐wide association studies with expression quantitative trait locus (eQTL) data from bulk tissues to identify stroke susceptibility genes. However, eQTL data exhibit high cell‐type specificity, and genetic
Yijie He, Tao Zhang, Ping Zhu, Shan Gao, Shiyang Wu, Fengzhen Liu, Yan Chen, Yingshui Yao, Guiyou Liu   +8 more
doaj   +1 more source

Effects of antiplatelet therapy on stroke risk by brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases: subgroup analyses of the RESTART randomised, open-label trial. [PDF]

Lancet Neurol, 2019
Background Findings from the RESTART trial suggest that starting antiplatelet therapy might reduce the risk of recurrent symptomatic intracerebral haemorrhage compared with avoiding antiplatelet therapy.
Al-Shahi Salman R, Minks DP, Mitra D, Rodrigues MA, Bhatnagar P, du Plessis JC, Joshi Y, Dennis MS, Murray GD, Newby DE, Sandercock PAG, Sprigg N, Stephen J, Sudlow CLM, Werring DJ, Whiteley WN, Wardlaw JM, White PM, RESTART Collaboration.   +18 more
europepmc   +2 more sources

Asymptomatic Cerebral Small Vessel Disease: Insights from Population-Based Studies [PDF]

Journal of Stroke, 2019
Cerebral small vessel disease (CSVD) is a common group of neurological conditions that confer a significant burden of morbidity and mortality worldwide.
Alvin S. Das, Robert W. Regenhardt, Meike W. Vernooij, Deborah Blacker, Andreas Charidimou, Anand Viswanathan   +5 more
doaj   +1 more source

Neuroimaging Characteristics of Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) in Korean Based on Jeju Cohort: A Pictorial Essay

Journal of the Korean Society of Radiology, 2023
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a hereditary small artery vasculopathy caused by mutations in the NOTCH3 gene on chromosome 19.
Yeh Rin Suh, Ho Kyu Lee, Kyeong Ho Jung, Jung Seok Lee, Jay Chol Choi   +4 more
doaj   +1 more source

Nonfocal Transient Neurological Attacks Are Associated With Cerebral Small Vessel Disease

, 2019
Background and Purpose-Nonfocal transient neurological attacks (TNAs), such as unsteadiness, bilateral weakness, or confusion, are associated with an increased risk of stroke and dementia.
Greving, Jacoba P., Kappelle, L. Jaap, Oudeman, Eline A., Bron, Esther E., Biessels, Geert Jan, Van den Berg-Vos, Renske M., de Bresser, Jeroen, van Oostenbrugge, Robert   +7 more
core   +1 more source