Results 51 to 60 of about 98,582 (280)

Cerebral small vessel disease: A glymphopathy?

Current Opinion in Neurobiology, 2022
Small vessel disease (SVD) is a common instigator of dementia in the aging population. The hallmarks of SVD are enlargement of the perivascular spaces and white matter hyperintensities. The latter represents local fluid accumulation in white matter that either subsides or develops into lacunar infarcts.
Benveniste, Helene, Nedergaard, Maiken
openaire   +3 more sources

增龄相关性脑小血管病谱系的病理基础及其影像学特点 Pathological Basis and Imaging Characteristics of Spectrum of Age-related Cerebral Small Vessel Diseases

Zhongguo cuzhong zazhi, 2019
增龄相关性脑小血管病谱系（spectrum o f a ge-related cerebral small vessel diseases， ArCSVDS）是指随着年龄的增长，脑小动脉、微动脉、毛细血管、微静脉、小静脉出现老化的一组脑 小血管病（cerebral small vessel disease，CSVD），包括深穿支动脉病（deep perforating arteriopathy，DPA） 和β淀粉样蛋白（β-amyloid，Aβ）有关的脑淀粉样血管病（cerebral amyloid ...
陆正齐，宋康宇
doaj   +1 more source

A novel COL4A1 variant associated with recurrent epistaxis and glioblastoma

Human Genome Variation, 2021
COL4A1-related disorders are characterized by a higher incidence of cerebral hemorrhage than other hereditary cerebral small vessel diseases. Accumulating data have shown broad phenotypic variations, and extracerebral hemorrhages have been linked to ...
Kohei Muto, Ryosuke Miyamoto, Yuka Terasawa, Yoshimitsu Shimatani, Keijiro Hara, Takumi Kakimoto, Tatsuya Fukumoto, Yusuke Osaki, Koji Fujita, Masafumi Harada, Hisanori Uehara, Yasushi Takagi, Yuishin Izumi   +12 more
doaj   +1 more source

Cerebral Small Vessel Disease and Alzheimer's Disease: A Review

Frontiers in Neurology, 2020
Alzheimer's disease (AD) is the most common cause of dementia. Despite this, clear pathophysiology for AD has not been confirmed, and effective treatments are still not available.
Hae Won Kim, Jeongho Hong, Jae Cheon Jeon   +2 more
doaj   +1 more source

Contributions of Aging to Cerebral Small Vessel Disease [PDF]

Annual Review of Physiology, 2020
Cerebral small vessel disease (SVD) is characterized by changes in the pial and parenchymal microcirculations. SVD produces reductions in cerebral blood flow and impaired blood-brain barrier function, which are leading contributors to age-related reductions in brain health.
T Michael, De Silva, Frank M, Faraci
openaire   +2 more sources

Integration of Genome‐Wide Association Studies With Single‐Cell and Bulk Expression Quantitative Trait Locus to Identify Stroke Susceptibility Genes

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Previous studies have integrated genome‐wide association studies with expression quantitative trait locus (eQTL) data from bulk tissues to identify stroke susceptibility genes. However, eQTL data exhibit high cell‐type specificity, and genetic
Yijie He, Tao Zhang, Ping Zhu, Shan Gao, Shiyang Wu, Fengzhen Liu, Yan Chen, Yingshui Yao, Guiyou Liu   +8 more
doaj   +1 more source

Asymptomatic Cerebral Small Vessel Disease: Insights from Population-Based Studies [PDF]

Journal of Stroke, 2019
Cerebral small vessel disease (CSVD) is a common group of neurological conditions that confer a significant burden of morbidity and mortality worldwide.
Alvin S. Das, Robert W. Regenhardt, Meike W. Vernooij, Deborah Blacker, Andreas Charidimou, Anand Viswanathan   +5 more
doaj   +1 more source

Neuroimaging Characteristics of Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) in Korean Based on Jeju Cohort: A Pictorial Essay

Journal of the Korean Society of Radiology, 2023
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a hereditary small artery vasculopathy caused by mutations in the NOTCH3 gene on chromosome 19.
Yeh Rin Suh, Ho Kyu Lee, Kyeong Ho Jung, Jung Seok Lee, Jay Chol Choi   +4 more
doaj   +1 more source

Monogenic cerebral small-vessel diseases: diagnosis and therapy. Consensus recommendations of the European Academy of Neurology. [PDF]

, 2020
BACKGROUND AND PURPOSE: Guidelines on monogenic cerebral small-vessel disease (cSVD) diagnosis and management are lacking. Endorsed by the Stroke and Neurogenetics Panels of the European Academy of Neurology, a group of experts has provided ...
FILLA, A., Federico, A, Filla, A, TOURNIER-LASSERVE, E., Bersano A., Tournier-Lasserve, E, Finsterer J., Arnold M., FINSTERER, J., MARKUS, H. S., S. Debette, Lesnik Oberstein S., H. S. Markus, A. Federico, Markus, H.S., Hunt, D, Burlina, A, A. Bersano, H. Chabriat, Filla A., D. Hunt, Finsterer, J, Federico A., Arnold, M., Mancuso, M, Enzinger, C, A. Burlina, Lesnik Oberstein, S, LESNIK OBERSTEIN, S., Markus, H S, S. Lesnik Oberstein, Tournier-Lasserve E., Markus H. S., MANCUSO, M., J. Finsterer, CHABRIAT, H., ENZINGER, C., DEBETTE, Stephanie, Oberstein, S.L., FEDERICO, A., Arnold, Maurice, Enzinger C., BERSANO, A., Chabriat, H, BURLINA, A., Debette, S., Hunt D., M. Mancuso, Mancuso M., HUNT, D., Chabriat H., Bersano, A, C. Enzinger, M. Arnold, Debette, S, Debette S., Burlina A., A. Filla, E. Tournier‐Lasserve   +58 more
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CADASIL Affects Multiple Aspects of Cerebral Small Vessel Function on 7T-MRI [PDF]

, 2022
ObjectiveCerebral small vessel diseases (cSVDs) are a major cause of stroke and dementia. We used cutting-edge 7T-MRI techniques in patients with Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL), to ...
Benno Gesierich, Stringer, Michael, S, Duering, Marco, Wardlaw, Joanna, M, Arts, Tine, Hübner, Mathias, Gesierich, Benno, Biessels, Geert Jan, Stringer, Michael S., Mathias Hübner, Marco Duering, Geert Jan Biessels, Anna Kopczak, Hein, Sandra, Biessels, Geert, Jan, Tine Arts, Joanna M. Wardlaw, Van Den Brink, Hilde, Laurien Onkenhout, Jeroen Hendrikse, Siero, Jeroen C. W., Onkenhout, Laurien, Hendrikse, Jeroen, Joutel, Anne, Jeroen C.W. Siero, Sandra Hein, Brink, Hilde van den, Dichgans, Martin, Michael S. Stringer, Martin Dichgans, Zwanenburg, Jaco J. M., Huebner, Mathias, Jaco J.M. Zwanenburg, Anne Joutel, Wardlaw, Joanna M., Hilde van den Brink, Siero, Jeroen C.w., Zwanenburg, Jaco J.m., Kopczak, Anna   +38 more
core   +1 more source