Results 51 to 60 of about 7,881,496 (248)

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Blood-Brain Barrier Dysfunction in Small Vessel Disease Related Intracerebral Hemorrhage [PDF]

, 2018
Background and Purpose: Hypertensive vasculopathy and cerebral amyloid angiopathy are the two most common forms of cerebral small vessel disease.
Jacobs, Heidi I. L., Frans R. Verhey, Verhey, Frans R., Floris H. B. M. Schreuder, Robert J. van Oostenbrugge, Freeze, W.M., Oostenbrugge, R.J. van, Walter H. Backes, Catharina J. M. Klijn, van Oostenbrugge, Robert J., Heidi I. L. Jacobs, Freeze, Whitney M., Verhey, F.R.J., Klijn, Catharina J. M., Schreuder, Floris H. B. M., Klijn, C.J.M., Whitney M. Freeze, Backes, Walter H., Schreuder, F.H.B.M., Jacobs, H.I., Backes, W.H.   +20 more
core   +2 more sources

Cerebrovascular ischemic changes associated with fetal posterior cerebral artery- descriptive retrospective study with magnetic resonance imaging and angiography of brain [PDF]

Al Ameen Journal of Medical Sciences, 2016
Objectives: Circle of Willis, the main collateral pathway for cerebral circulation, is complete in only a portion of the population. There are many variations in the Circle of Willis.
Venkatraman Indiran, Prabakaran Maduraimuthu   +1 more
doaj  

Identification and characterisation of calcitonin receptor isoforms expressed in glioblastoma derived glioma stem and U‐87 MG cells

FEBS Open Bio, EarlyView.
Glioblastoma cells express calcitonin receptor variants (CT receptor isoforms) that may help them survive stress. Using qPCR, transcript‐specific long‐read nanopore sequencing, immunofluorescence co‐localisation and comparative sequence analysis, this study identifies a novel alternatively spliced CALCR transcript that encodes the CTb receptor isoform ...
Pragya Gupta, Sebastian GB Furness, Tahereh Gharbi, Ric De Paoli‐Iseppi, Shweta S. Joshi, Michael Clark, David L. Hare, Peter Wookey   +7 more
wiley   +1 more source

Cerebral small vessel disease (CSVD) with Romberg sign and falls

, 2023
A man in his 70s reported a 3-month history of unsteady gait and falls. His gait was previously normal. He had no symptoms or signs of stroke. He had a 6-year history of impaired verbal fluency and mild executive dysfunctions, consistent with cerebral ...
Chan, L.K.M., Chan, Daniel Kam Yin, Chan, Luke Kar Man, Chan, Daniel Kam Yin (R17535)   +3 more
core   +1 more source

SPG4 and Dementia: Expanding the Clinical Spectrum

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Hereditary spastic paraplegia (HSP) is a group of disorders characterized by progressive spasticity and lower limb weakness, with mutations in SPG4/SPAST being the most common cause. Detailed studies and clinical and molecular comparisons across different populations are missing.
Emanuele Panza, Arun Meyyazhagan, Eliseo Picchi, Gustavo Ribas, Ingrid Faber, Ryosuke Miyamoto, Preethi Basavaraju, Paolo Eusebi, Haripriya Kuchi Bhotla, Mario Stasi, Fabrizio Gaudiello, Francesco Patti, Filippo Maria Santorelli, Marcondes Cavalcante França Jr, José Luiz Pedroso, Orlando Graziani Povoas Barsottini, Hélio Afonso Ghizoni Teive, Peter Henry St George‐Hyslop, Toshitaka Kawarai, Antonio Orlacchio   +19 more
wiley   +1 more source

Effects of Carotid Artery Stiffness on Cerebral Small‐Vessel Disease and Cognition

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2022
Background Carotid artery stiffness is associated with cognitive impairment and dementia, but the underlying mechanisms remain unknown. We examined the associations of carotid artery stiffness with cerebral small‐vessel disease markers, cognition, and ...
Caroline Robert, Lieng‐Hsi Ling, Eugene S. J. Tan, Bibek Gyanwali, Narayanaswamy Venketasubramanian, Shir Lynn Lim, Lingli Gong, Josephine Lunaria Berboso, Arthur Mark Richards, Christopher Chen, Saima Hilal   +10 more
doaj   +1 more source

High‐Resolution MRI Revealed Different Etiology‐Specific Associations With Cerebral Infarction in Adult Moyamoya Vasculopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective High‐resolution MRI enables detailed assessment of intracranial vessel wall pathology in moyamoya vasculopathy. We aimed to classify adult moyamoya vasculopathy etiologies using high‐resolution MRI and to examine subtype‐specific associations between high‐resolution MRI features and ischemic infarction.
Guangsong Han, Jiachun Pan, Yuehui Hong, Xiaoyuan Fan, Ming Yao, Lixin Zhou, Yicheng Zhu, Feng Feng, Jun Ni   +8 more
wiley   +1 more source

Imaging-validated correlates and implications of the pathophysiologic mechanisms of ageing-related cerebral large artery and small vessel diseases: a systematic review and meta-analysis

Behavioral and Brain Functions
Background Cerebral large artery and small vessel diseases are considered substrates of neurological disorders. We explored how the mechanisms of neurovascular uncoupling, dysfunctional blood–brain-barrier (BBB), compromised glymphatic pathway, and ...
Joseph A. Ackah, Xuelong Li, Huixing Zeng, Xiangyan Chen   +3 more
doaj   +1 more source

Progressive Cerebral Small Vessel Disease Caused by an Autoimmune Response to Intravesical Bacille-Calmette-Guérin Treatment

Frontiers in Neurology, 2020
Systemic BCGitis and autoimmune diseases are possible adverse events of intravesical Bacille Calmette-Guérin-(BCG)-instillations in the treatment of urothelioma cancer.
Anouck Becker, Iris Quasar Grunwald, Iris Quasar Grunwald, Marcus M. Unger, Stefanie Behnke, Joerg Spiegel, Umut Yilmaz, Silke Walter, Silke Walter, Klaus Faßbender   +9 more
doaj   +1 more source