Results 71 to 80 of about 7,881,496 (248)

Estados alterados de la conciencia tras un daño cerebral [PDF]

, 2021
Las personas somos conscientes de nosotras mismas y de nuestro entorno a través de la conciencia. No obstante, los estados alterados de la conciencia son situaciones como el coma u otros estados clínicos en los que personas con un daño cerebral severo no
Federación Española de Daño Cerebral
core  

Characterization of cerebral small vessel disease by neutrophil and platelet activation markers using artificial intelligence

, 2022
Cerebral small vessel disease (cSVD) accounts for 25% of ischemic strokes and is a major cause of cognitive decline. Inflammatory processes, involving immune cells and platelets might drive development and progression of cSVD. The aim of the study was to
Koenen, R R; id_orcid, Cosemans, J M E M, Cosemans, J M E M; id_orcid, Roosen, M G C H, Koenen, R R, Tullemans, B M E, Karel, M F A, Zhang, C Eleana, Staals, J   +8 more
core   +1 more source

Predictive Value of Composite Inflammatory Markers for Stroke Prognosis: A Prospective Cohort Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Novel composite inflammatory markers' role in stroke prognosis is understudied, and the best predictor is unclear, requiring further exploration. Objectives This study aimed to systematically evaluate the associations of 6 novel composite inflammatory markers on stroke prognosis.
Bing Wu, Jie‐Jie Li, Jing Jing, Jin‐Xi Lin, Xia Meng, Yong Jiang, Yong‐Jun Wang, Hong‐Qiu Gu   +7 more
wiley   +1 more source

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem, Noa Bielopolski, Vijai Krishnan, Shane Wald‐Altman, Shelly I Shrian, Omer Bar‐Yosef, Livia Kapusta, Claire Shamber, Patricia L. Musolino, Miguel Weil   +9 more
wiley   +1 more source

3D reconstruction of cerebral blood flow and vessel morphology from x-ray rotational angiography [PDF]

, 2009
Three-dimensional (3D) information on blood flow and vessel morphology is important when assessing cerebrovascular disease and when monitoring interventions.
Wächter, I., Wächter, I
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Genetic determinants of blood lipids and cerebral small vessel disease: role of high-density lipoprotein cholesterol [PDF]

, 2020
Blood lipids are causally involved in the pathogenesis of atherosclerosis, but their role in cerebral small vessel disease remains largely elusive.
Malik, Rainer, Parhofer, Klaus G., Georgakis, Marios K., Hopewell, Jemma C., Anderson, Christopher D., Dichgans, Martin   +5 more
core   +1 more source

Diabetic cerebral microvascular disorder: from key pathologies to targeted interventions

Annals of Medicine
Background Diabetes mellitus, a highly prevalent metabolic disorder worldwide, poses a severe threat to patient health primarily through its debilitating vascular complications.
Qihan Zhang, Jia Liu, Xunming Ji
doaj   +1 more source

Association Between Endothelial Cell Stabilizing Medication and Small Vessel Disease Stroke: A Case-Control Study

Frontiers in Neurology, 2019
Increasing evidence suggests a role for endothelial cell (EC) dysfunction in pathogenesis of cerebral small vessel disease. Commonly used medications including certain antihypertensives and statins have EC-stabilizing effects.
Charlotte Elisabeth Becker, Charlotte Elisabeth Becker, Terence J. Quinn, Anna Williams   +3 more
doaj   +1 more source

White Matter and Perivascular Imaging Changes in Alzheimer's Disease and Cerebral Amyloid Angiopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Peak‐width of skeletonized mean diffusivity (PSMD) and diffusion tensor imaging–analysis along the perivascular space (DTI‐ALPS), reflecting white matter integrity and glymphatic function, are altered in Alzheimer's disease (AD).
Debina Laishram, Guangwei Du, Sangam Kanekar, Nandakumar Nagaraja   +3 more
wiley   +1 more source

Vessel-Associated Immune Cells in Cerebrovascular Diseases:From Perivascular Macrophages to Vessel-Associated Microglia

, 2019
Cerebral small vessels feed and protect the brain parenchyma thanks to the unique features of the blood-brain barrier. Cerebrovascular dysfunction is therefore seen as a detrimental factor for the initiation of several central nervous system (CNS ...
Koizumi, Takashi, Mizuno, Toshiki, Steinbusch, Harry W. M., Foulquier, Sebastien; id_orcid, Foulquier, Sebastien, Kerkhofs, Danielle   +5 more
core   +1 more source