Results 91 to 100 of about 8,233,957 (244)

Multivariate analysis for the progression of cerebral small vessel disease.

, 2019
Multivariate analysis for the progression of cerebral small vessel disease.
Tae-Jin Song (3270105), Dong-Ryeol Ryu (512374), Ho Geol Woo (7180775), Yoonkyung Chang (6802247)   +3 more
core   +1 more source

Engineered Brain‐Targeted Exosomes Delivering FGF1 for Sustained Glycemic Regulation and Multitarget Neurovascular Protection in Diabetic Stroke

Advanced Science, EarlyView.
ABSTRACT Diabetic stroke is characterized by a hyperglycemic and pro‐inflammatory microenvironment that exacerbates neurovascular dysfunction. However, the blood–brain barrier (BBB) remains a formidable obstacle, restricting the delivery of most therapeutic molecules.
Bixin Shen, Chengxiang Zhang, Junhui Wang, Xichong Zhong, Shihao Chen, Xue Wang, Xiaokun Li, Li Lin   +7 more
wiley   +1 more source

3D reconstruction of cerebral blood flow and vessel morphology from x-ray rotational angiography [PDF]

, 2009
Three-dimensional (3D) information on blood flow and vessel morphology is important when assessing cerebrovascular disease and when monitoring interventions.
Wächter, I., Wächter, I
core  

Pathophysiology of cerebral small vessels in vascular cognitive impairment

, 2003
Cerebral small-vessel alterations play a central role in determining lesions of subcortical structures and eventually may lead to cognitive impairment. Small-vessel diseases are classified according to the pathological viewpoint.
Simoni, Michela, Pantoni, Leonardo
core   +1 more source

Endothelial miR‐15a/16‐1 Regulation of SYNE1 Mediates Structural and Functional Recovery after Traumatic Brain Injury

Advanced Science, EarlyView.
Endothelial miR‐15a/16‐1 deletion promotes long‐term recovery after traumatic brain injury by restoring SYNE1 expression. Enhanced endothelial SYNE1 preserves vascular integrity, protects white and gray matter, and improves neurological function. The endothelial miR‐15a/16‐1–SYNE1 axis emerges as a key regulator of neurovascular repair and a potential ...
Shun Li, Na Qiu, Chao Zhou, Andrew Ni, Ping Sun, Jia‐Jun Liu, Xin‐Lei Huang, Tian‐Qing Xiong, Yu‐Chi Zhang, Hai‐Zhou Liu, Xiao‐Tao Xu, Rui Wang, Shi‐Qing Zhang, Yu‐Xin Zhang, Silvia Liu, C. Edward Dixon, Jun Chen, Ke‐Jie Yin   +17 more
wiley   +1 more source

Entorhinal Astrocyte Transplants Restore Spatial Exploration and Alleviate Amyloid‐Beta Pathology in Alzheimer's Mice

Advanced Science, EarlyView.
Impaired MEC astrocytic Ca2+ signaling is associated with fragmented spatial exploration in AD mice. Region‐specific glial progenitor transplantation generates engrafted astrocytes that are accompanied by improved AQP4 polarization, reduced amyloid‐β‐associated pathology, attenuated neuroinflammation, preserved synaptic integrity, and ameliorated ...
Fengjuan Wu, Jihua Fan, Xiang Zhou, Zhiqi Yang, Mingyue Gong, Mingzhu Huang, Zhenlu Cai, Shaofan Yang, Teng Teng, Chuanyan Yang, Jin Li, Haoyu Wang, Shuangshuang Dai, Chunhai Chen, Xiaowei Chen, Manxia Wang, Kuan Zhang   +16 more
wiley   +1 more source

Stroke, Small‐Vessel Disease, and Occupation: Systematic Review and Data Analysis

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Novel risk factors for stroke, such as occupation, are increasingly under exploration. We investigate if specific occupational exposures and settings increase the risk of developing small‐vessel disease (SVD), including SVD‐related strokes ...
Thomas Zhang, Una Clancy, Ayush Singh, Stephen Makin, Caroline McHutchison, Vera Cvoro, Carmen Arteaga‐Reyes, Daniela Jaime Garcia, Will Hewins, Michael Stringer, Michael Thrippleton, Maria C. Valdes‐Hernandez, Stewart Wiseman, Francesca Chappell, Rosalind Brown, Fergus Doubal, Joanna M. Wardlaw   +16 more
doaj   +1 more source

TAB2 Causes Neuronal Damage by Aggravating Microglia‐Mediated Neuroinflammation in Parkinson's Disease

Advanced Science, EarlyView.
In microglia, STAT3 upregulates TAB2, which promotes NF‐κB activation through its NZF domain‐mediated recognition of K63‐linked ubiquitin chains, leading to inflammatory cytokine release and subsequent neuronal injury. Lumacaftor suppresses TAB2 expression and directly binds the TAB2‐NZF domain to interrupt K63 ubiquitin recognition, thereby blocking ...
Yanhao Zhao, Zimeng Huang, Jianing Gao, Aolan Li, Huizhi Wang, Yingchuan Chen, Guanyu Zhu, Xin Zhang, Yin Jiang, Moxuan Zhang, Fangang Meng, Jianguo Zhang, Tingting Du   +12 more
wiley   +1 more source

A Vessel for Change: Endothelial Dysfunction in Cerebral Small Vessel Disease [PDF]

, 2020
The blood vessels of the brain are lined with endothelial cells and it has been long known that these help to regulate blood flow to the brain. However, there is increasing evidence that these cells also interact with the surrounding brain tissue.
Williams, A, Moss, J, Quick, S, Rajani, RM   +3 more
core   +1 more source

Advances in retinal imaging biomarkers for the diagnosis of cerebrovascular disease

Frontiers in Neurology
The increasing incidence and mortality rates of cerebrovascular disease impose a heavy burden on both patients and society. Retinal imaging techniques, such as fundus photography, optical coherence tomography, and optical coherence tomography angiography,
Yier Zhang, Ting Zhao, Ling Ye, Sicheng Yan, Wuyue Shentu, Qilun Lai, Song Qiao, Song Qiao   +7 more
doaj   +1 more source