Results 91 to 100 of about 7,881,496 (248)

Advanced Materials for Biologics Delivery to Brain Tumors

Advanced Materials, EarlyView.
Material innovation is central to unlocking the therapeutic potential of biologics against many central nervous system diseases, including brain cancer. By engineering carriers with controlled transport, targeting, and release properties, advanced materials can overcome the blood–brain barrier and tumor microenvironment, improving the delivery of ...
Yuran Feng, Yuxue Cao, Maria Kavallaris, Taskeen Janjua, Amirali Popat   +4 more
wiley   +1 more source

Developing treatments for cerebral small vessel disease: a scoping review of licensed interventions for potential repurposing [PDF]

Background: Cerebral small vessel disease (cSVD) is a progressive neurovascular-degenerative condition without specific treatment that causes lacunar stroke, most intracerebral haemorrhage, vascular cognitive impairment (VCI) and several neuropsychiatric
P Phan, Elizabeth, Pal, Suvankar, Malhotra, Paresh, M Bath, Philip, Clay, Gwynneth, Dawson, Jesse, Macleod, Malcolm, M Wardlaw, Joanna, Howard, Rob, Quinn, Terry   +9 more
core   +1 more source

Cross‐Scale Hierarchical Targeted Delivery System Based on Small‐Scale Magnetic Robots

Advanced Robotics Research, EarlyView.
This article reviews a cross‐scale hierarchical targeted delivery system that integrates magnetic continuum robots and magnetic microrobots. By combining rapid long‐range navigation with precise microscale targeting, the system overcomes key limitations of single‐scale approaches.
Junjian Zhou, Zhiqiang Chen, Yuanbiao Ma, Zhiqiang Tang, Qianqian Wang   +4 more
wiley   +1 more source

Cerebral small vessel disease and Alzheimer’s disease

, 2015
Zhiyou Cai,1 Chuanling Wang,1 Wenbo He,1 Hanjun Tu,2 Zhengang Tang,3 Ming Xiao,4 Liang-Jun Yan51Department of Neurology, Renmin Hospital, Hubei University of Medicine, 2Department of Basic Research Center, Hubei University of Medicine, 3Department of ...
Yan LJ, Tang Z, Xiao M, Wang C, He W, Cai Z, Tu H   +6 more
core  

Decreased kidney function relates to progression of cerebral microbleeds in lacunar stroke patients

, 2016
Background It is hypothesized that impaired kidney function and cerebral microbleeds represent microvascular damage in different organs. Several cross-sectional studies found impaired kidney function to be associated with the presence of cerebral ...
van Oostenbrugge, Robert J., Staals, Julie, van Overbeek, Ellen C.   +2 more
core   +1 more source

Magnetic Micro‐ and Nanorobots for Precision Thrombolysis: Design Strategies and Translational Challenges

Advanced Robotics Research, EarlyView.
Micro‐ and nanorobots for targeted thrombolysis. This perspective elaborates on the clinical indication of blood clot disorders and current limitations for treatment. As a novel, alternative solution, micro‐ and nanorobots can be used to treat and break down thrombi.
Joshua M. Mesfin, Yimo Yan, Nikola Cesarovic, Simone Schuerle   +3 more
wiley   +1 more source

Impact of small vessel disease in the brain on gait and balance [PDF]

, 2017
Gait and balance impairment is highly prevalent in older people. We aimed to assess whether and how single markers of small vessel disease (SVD) or a combination thereof explain gait and balance function in the elderly. We analysed 678 community-dwelling
Gow, Alan, Deary, Ian J., Pattie, Alison, Gattringer , Thomas, Gattringer, Thomas, Starr, John M., Gow, Alan J., Muñoz Maniega, Susana; id_orcid, Staals, Julie, Bastin, Mark E., Royle, Natalie, Ritchie, Stuart J., Doubal, Fergus, Enzinger, Christian, Maniega, Susana Munoz, Morris, Zoe, Pinter, Daniela, Valdes Hernandez, Maria, Royle, Natalie A., Dickie, David A., Ritchie, Stuart J, Hernandez, Maria del C. Valdes, Muñoz Maniega, Susana, Fazekas, Franz, Corley, Janie, Deary, Ian, Gow, Alan J.; id_orcid, Hernández, Maria Del C Valdés, Dickie, David Alexander, Starr, John, Wardlaw, Joanna, del C. Valdés Hernández, Maria, Bastin, Mark   +32 more
core   +1 more source

Intelligent Micro/Nanorobots for Targeted Interventional Therapy: From Bench to Clinic

Advanced Robotics Research, EarlyView.
Zirui Zhang et al. reviewed the application and challenges of mobile nanomachines in interventional therapy. By converting exogenous energy, including chemical, magnetic, optical, and ultrasonic sources, into mechanical forces, micro/nanorobots (MNRs) enable precise actuation at unprecedented scales. Evolving far beyond traditional drug delivery, these
Zirui Zhang, Yu Dong, Yongsheng Du, Rui Gao, Lin Zhang, Fei Tong   +5 more
wiley   +1 more source

Progress of relationship between cerebral microbleeds and intracranial hemorrhage secondary to cerebral ischemic events

Chinese Journal of Contemporary Neurology and Neurosurgery, 2019
Cerebral microbleeds (CMBs) are typical neuro-imaging marker of cerebral small vessel disease (cSVD), representing that some small intracranial vessels rupture have occured in the past. Correlation between CMBs and intracranial hemorrhage (ICH) secondary
Jie ZHUO
doaj  

White Matter Hyperintensities: Cerebral Small‐Vessel Diseases and White Matter Microstructural Impairments

iRADIOLOGY
White matter hyperintensities (WMH) are very widespread in older adults and are imaging features of both cerebral small‐vessel disease and white matter microstructural impairments. Recent studies have demonstrated a close association between WMH and some
Hui Huang, Wei Song, Pengyu Wang, Ye Zhu, Lei Zheng, Chenzhen Shen, Hui Xu, Jianfeng Qiu   +7 more
doaj   +1 more source