Results 101 to 110 of about 7,881,496 (248)

Human‐Scale Rotating Magnetic Field Delivery With Permanent Magnets Under Anatomic and Robotic Constraints

Advanced Robotics Research, EarlyView.
Rotating magnetic fields (RMFs) are widely used for microrobot propulsion and control. We show that RMF generation with permanent magnets is mechanically feasible for many limb and intracranial applications but becomes constrained for thoracic targets.
Tuan‐Anh Le, Husnu Halid Alabay, Anika Sivarasa, Gia‐Minh Hoang, Hakan Ceylan   +4 more
wiley   +1 more source

CARASIL with coronary artery disease and distinct cerebral microhemorrhage: A case report and literature review

Clinical and Translational Neuroscience, 2020
Cerebral Autosomal Recessive Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CARASIL, Maeda syndrome) is an extremely rare autosomal-recessive genetic disorder with a serious arteriopathy causing subcortical infarcts and ...
Sebastian J Müller, Eya Khadhraoui, Ibrahim Allam, Loukas Argyriou, Ute Hehr, Jan Liman, Gerd Hasenfuß, Mathias Bähr, Christian H Riedel, Jan C Koch   +9 more
doaj   +1 more source

Phosphorylation‐Facilitated CKB Lactylation At K11 By GCN5 Enhances Creatine Kinase Activity and Mitigates Neuronal Damage After Cerebral Ischemia‐Reperfusion

Advanced Science, EarlyView.
This study uncovers hierarchical coordination between K11 lactylation and S199 phosphorylation of CKB in cerebral ischemia‐reperfusion injury. Such dual modifications potentiate CKB enzymatic function, remodel energy metabolism, alleviate oxidative stress and neuronal damage, and represent a viable therapeutic target for stroke treatment.
Chao Duan, Ruolin Zhang, Shihui Ding, Ying Feng, Tao Shen, Ziwei Wang, Wendai Bao, Ke Shui, Jun Qin, Jun Chen, Min Zhang, Zijing Ren, Dongmei Zhao, Xingrong Guo, Zhibing Ai, Xin Yang, Peiyang Zhou, Zhiqiang Dong   +17 more
wiley   +1 more source

Advancing our knowledge about cerebral small vessel diseases. [PDF]

Lancet Neurol, 2023
Gorelick PB, Sorond FA.
europepmc   +1 more source

Modulation of miR‐23b Wnt/β‐catenin Axis Strengthens Endothelial Barrier Properties

Advanced Science, EarlyView.
Early blood‐brain barrier (BBB) disruption contributes to stroke and CNS disease pathology. miR‐23b was identified as a regulator of BBB integrity in brain endothelial cells. Inhibition of miR‐23b enhanced barrier‐associated properties, promoted repair‐related signaling, and reduced BBB leakage in experimental stroke models, supporting further ...
Victor Anthony Martinez, Rose E. Presby, Sara Nakanishi, Pallavi Gaur, Ugur Akcan, Johannes Daugaard Krog, Iben Daugaard Krog, Lipi Das, David S. Johnson, Danny Jamoul, Douglas Jury, Brian Lawson, Jacob Körbelin, Lewis M. Brown, Vilas Menon, Dritan Agalliu, Irene Munk Pedersen   +16 more
wiley   +1 more source

MRI features of cerebral small vessel disease [PDF]

, 2019
Cerebral small vessel disease affects brain vessels with the smallest caliber - small arteries, arterioles, venules, capillaries. There is strong association with cognitive impairment, dementia, psychiatric conditions, gait disturbances. The main markers
Balev, Boyan; Medical University of Varna, Kalchev, Emilian; Medical University of Varna, Georgiev, Radoslav; Medical University of Varna   +2 more
core   +5 more sources

Thermochemical Micro‐Explosion for Prompt Thrombolysis via Proximal Injection of Liquid Alkali Metal

Advanced Science, EarlyView.
We report a micro‐explosive thermochemical thrombolysis (METCT) therapy via injectable liquid alkali metal encapsulated in dimethyl silicone (LAM@oil). METCT enables prompt and safe vascular recanalization within 90 s. Critically, the LAM@oil system demonstrates significantly higher thrombolytic efficacy compared to clinically available thrombolytic ...
Xin Liao, Yi Hou, Jie Zhang, Bo Wang, Minghui Guo, Hua Qu, Wei Rao, Jing Liu   +7 more
wiley   +1 more source

Stroke, Small‐Vessel Disease, and Occupation: Systematic Review and Data Analysis

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Novel risk factors for stroke, such as occupation, are increasingly under exploration. We investigate if specific occupational exposures and settings increase the risk of developing small‐vessel disease (SVD), including SVD‐related strokes ...
Thomas Zhang, Una Clancy, Ayush Singh, Stephen Makin, Caroline McHutchison, Vera Cvoro, Carmen Arteaga‐Reyes, Daniela Jaime Garcia, Will Hewins, Michael Stringer, Michael Thrippleton, Maria C. Valdes‐Hernandez, Stewart Wiseman, Francesca Chappell, Rosalind Brown, Fergus Doubal, Joanna M. Wardlaw   +16 more
doaj   +1 more source

Organoid Brain‐Machine‐Interface Devices for Central Nervous System Repair

Advanced Science, EarlyView.
We envision organoid brain‐machine‐interface (Organoid‐BMI) devices as new biohybrid bidirectional communication pathways to connect the human CNS and the external world for personalized CNS repair and regeneration. ABSTRACT Central nervous system (CNS) repair and regeneration suffer from tremendous clinical challenges due to current limitations in ...
Yantao Xing, Yang Yang, Zichen Hong, Chunhui Tian, Huiyu Chu, Susanne Clara Prokop, Hongwei Cai, Mingxia Gu, Jason Tchieu, Ken Mackie, Feng Guo   +10 more
wiley   +1 more source

Hereditary cerebral small vessel disease and stroke

, 2017
Cerebral small vessel disease is considered hereditary in about 5% of patients and is characterized by lacunar infarcts and white matter hyperintensities on MRI.
Hansen, Christine Krarup, Christian Baastrup Søndergaard, Jørgen Erik Nielsen, Nielsen, Jørgen Erik, Christensen, Hanne, Søndergaard, Christian Baastrup, Christine Krarup Hansen, Hanne Christensen   +7 more
core   +1 more source