Results 111 to 120 of about 8,233,957 (244)

Critical closing pressure as a new hemodynamic marker of cerebral small vessel diseases burden. [PDF]

Front Neurol, 2023
Fu X, Zhang W, Li X, Liu H, Zhang Y, Gao Q.   +5 more
europepmc   +1 more source

Restores Aβ Clearance by Overcoming PCSK9–LRP1 Dysregulation and TRIB3‐Mediated Autophagy Blockade in Alzheimer's Disease

Advanced Science, EarlyView.
PCSK9 upregulation in cerebrovascular endothelial cells and microglia destabilizes the Aβ transporter LRP1, while TRIB3‐associated autophagy blockade further limits intracellular Aβ degradation. A RAP‐modified tea‐polyphenol nanoparticle co‐delivers siPCSK9 and siTRIB3 to restore LRP1‐mediated Aβ efflux and autophagy‐dependent degradation, reducing Aβ ...
Jie Miao, Jing Wang, Yankun Li, Haipei Zhang, Yanli Zhang, Qingnian Li, Bo Xiao, Wenhu Zhou, Junhong Guo   +8 more
wiley   +1 more source

Differential associations of lipoprotein(a) level with cerebral large artery and small vessel diseases

Stroke and Vascular Neurology
Background and purpose Cerebral large artery and small vessel diseases are related to different pathogenetic mechanisms and have different risk factor profile.
Yongjun Wang, Yilong Wang, Jing Jing, Hao Li, Xia Meng, Shan Li, Yuesong Pan, Aoming Jin, Xueli Cai, Tiemin Wei, Suying Wang, Lerong Mei, Yingying Yang, Yao DongXiao   +13 more
doaj   +1 more source

Cerebral Small Vessel Diseases and Outcomes for Acute Ischemic Stroke Patients after Endovascular Therapy. [PDF]

J Clin Med, 2022
Zhao Y, Ning Y, Lei L, Yuan H, Liu H, Luo G, Wei M, Li Y.   +7 more
europepmc   +1 more source

Alcohol Consumption and Cerebral Small- and Large-Vessel Diseases: A Mendelian Randomization Analysis [PDF]

Aims: It remains inconclusive regarding alcohol intake and stroke risk because determining risk factors depends on the specific pathogenesis of stroke. We used the variant rs671 in the aldehyde dehydrogenase 2 gene (ALDH2) as an instrument to investigate
矢野, 裕一朗, KADOTA, Aya, 0000-0001-6203-9339, NOZAKI, Kazuhiko, 156, 0000-0002-2565-7290, 1213, トリイ, サユキ, 7651, 00324567, 7377, OKAMURA, Tomonori, オカムラ, トモノリ, タバラ, ヤスハル, 70144483, 0000-0001-7378-0544, ヒサマツ, タカシ, 久松, 隆史, 20566567, 0000-0003-1623-068X, 鳥居, さゆ希, 30773973, 椎野, 顯彦, TORII, Sayuki, ノザキ, カズヒコ, YANO, Yuichiro, 岡村, 智教, MIURA, Katsuyuki, 60546068, コンドウ, ケイコ, 上島, 弘嗣, UESHIMA, Hirotsugu, 50215935, 近藤, 慶子, 9083, 三浦, 克之, 3536, SHIINO, Akihiko, 0000-0002-7742-4253, 10586241, 539, 90252452, TABARA, Yasuharu, ミウラ, カツユキ, 門田, 文, 0000-0002-2646-9582, 野﨑, 和彦, ヤノ, ユウイチロウ, KONDO, Keiko, カドタ, アヤ, 90257452, シイノ, アキヒコ, 田原, 康玄, 6336, HISAMATSU, Takashi, ウエシマ, ヒロツグ, 2935, 1647, 1966   +58 more
core   +1 more source

Longitudinal Awake Mouse Brain Imaging Using Functional Ultrasound and Functional Ultrasound Localization Microscopy

Advanced Science, EarlyView.
Awake longitudinal multimodal ultrasound imaging integrates functional ultrasound (fUS), ultrasound localization microscopy (ULM), and functional ULM (fULM) to characterize cerebrovascular function, microvascular architecture, and flow dynamics within the same animals over time.
Zhe Huang, Yike Wang, Matthew R. Lowerison, Yue Xu, Murong Yi, Bing‐Ze Lin, YiRang Shin, Nathiya Vaithiyalingam Chandra Sekaran, Daniel A. Llano, Pengfei Song   +9 more
wiley   +1 more source

Relationships between cerebral small vessel diseases markers and cognitive performance in stroke-free patients with atrial fibrillation. [PDF]

Front Aging Neurosci, 2022
Tao W, Liu J, Ye C, Kwapong WR, Wang A, Wang Z, Chen S, Liu M.   +7 more
europepmc   +1 more source

Remote Ischemic Post‐Conditioning Preserves the Neurovascular Unit by Brain‐Derived Gas6 That Drives Monocyte‐Derived Macrophage Reprogramming via Axl and Vimentin after SAH

Advanced Science, EarlyView.
Subarachnoid hemorrhage (SAH) triggers monocyte‐derived macrophage (MDM) infiltration and M1‐like polarization via Vimentin upregulation, leading to neurovascular unit disruption and cognitive dysfunction. Remote ischemic postconditioning (RIPostC) upregulates neuronal Gas6, which activates Axl on MDMs to downregulate Vimentin and drive reparative M2 ...
Yajun Zhu, Zichao Huang, Xi Rong, Xingwei Lei, Fuming Liang, Xiaoguo Li, Jiru Zhou, Yu Wang, Yifan Huang, Shuang Tang, Jianjun Zhong, Jin Yan, Hongji Deng, Chun Zeng, Zongduo Guo   +14 more
wiley   +1 more source

Heterozygous HTRA1 Mutations Cause Cerebral Small Vessel Diseases: Genetic, Clinical, and Pathologic Findings From 3 Chinese Pedigrees. [PDF]

Neurol Genet, 2022
Yao T, Zhu J, Wu X, Li X, Fu Y, Wang Y, Wang Z, Xu F, Lai H, He A, Teng L, Wang C, Song H.   +12 more
europepmc   +1 more source

Inhibition of MEKK3 Prevents Cerebral Cavernous Malformation Progression Via Restoring Endothelial Integrity and Restricting Microglial Activation

Advanced Science, EarlyView.
In this study, we demonstrate that aberrant MEKK3 signaling in endothelial cells and microglia drives the progression of cerebral cavernous malformations (CCMs). Furthermore, we identify DPDH as a potent small‐molecule MEKK3 inhibitor with substantial therapeutic potential for CCM treatment.
Weiwei Zheng, Suyun Yu, Liwenyu Chen, Jing Ma, Peiliang Shen, Chang Yu, Xiaoqing Xin, Qiuhong Shen, Jing Chen, Song Ke, Hao Liu, Xiaobing Jiang, Ruogu Qi, Juming Yan, Jia Li, Jaesung P. Choi, Yin Lu, Yang Zhao   +17 more
wiley   +1 more source