Results 131 to 140 of about 98,582 (280)

Development of a Human 3D Immune‐Competent Neurovascular Model Enabling Time‐Resolved Monitoring of Neuroinflammatory Dynamics and Neuroimmune Interactions

Advanced Science, EarlyView.
Neuroinflammation alters blood–brain barrier integrity and contributes to neurological disorders, yet existing models lack human immune complexity. This study presents a 3D, immune‐responsive platform that reconstructs key neurovascular components and enables real‐time monitoring.
Pavlo Gordiichuk, Jing Bai, Olurotimi A. Bolonduro, Andrew M. Silverman, Robert Madison Green, Jason H. Lasser, Paul W. Fleming, Lishomwa C. Ndhlovu, James F. Saunders, Dmitry Shvartsman   +9 more
wiley   +1 more source

Fractal Analysis of Retinal Vessels and their Relationship with Cerebral Microcirculation Pathology – A Narrative Review

Applied Medical Informatics, 2020
One of the most reliable in vivo examination methods of human microvasculature is represented by ophthalmoscopy. Due to ophthalmoscopy, retinal circulation can reveal multiple morphological details that can serve as diagnosis biomarkers for retinal ...
Adriana Elena Bulboacă, Paul Mihai BOARESCU   +1 more
doaj  

Additional file 1 of Monocyte to high-density lipoprotein cholesterol ratio is associated with cerebral small vessel diseases

Additional file 1: Table S1. Differences of characteristics between patients with and without lacune. Table S2. Differences of characteristics between patients with and without cerebral microbleeds. Table S3.
Hyung-Min Kwon (742360), Han-Yeong Jeong (4971829), Kyungha Min (11302340), Ki-Woong Nam (3829753), Jin-Ho Park (792152)   +4 more
core   +1 more source

A Skull Bone Marrow‐to‐Brain Axis Links Osteoblastic Activity to Myeloid Cell Trafficking, Cerebral Blood Flow, and Cognition in Alzheimer's Progression

Advanced Science, EarlyView.
This study reveals that Alzheimer's disease–linked APP expression in bone‐forming cells drives skull bone marrow remodeling and alters its vascular connections to the brain. These changes disrupt immune cell trafficking, cerebral blood flow, and cognition. Targeting bone marrow macrophages restores brain function, highlighting a previously unrecognized
Lei Xiong, Dong Sun, Hao‐Han Guo, Daehoon Lee, Zhipeng Liu, Lin Mei, Wen‐Cheng Xiong   +6 more
wiley   +1 more source

Genetic Causes of Cerebral Small Vessel Diseases: A Practical Guide for Neurologists. [PDF]

Neurology, 2023
Manini A, Pantoni L.
europepmc   +1 more source

JCB888967 Supplemetal Material - Supplemental material for Brain atrophy in cerebral small vessel diseases: Extent, consequences, technical limitations and perspectives: The HARNESS initiative

, 2019
Supplemental material, JCB888967 Supplemetal Material for Brain atrophy in cerebral small vessel diseases: Extent, consequences, technical limitations and perspectives: The HARNESS initiative by François De Guio, Marco Duering, Franz Fazekas, Frank-Erik ...
Steven M Greenberg (7905212), Eric Jouvent (120576), Agnès Aghetti (7905215), Joanna Wardlaw (259953), Frank-Erik De Leeuw (7905209), Franz Fazekas (160774), Leonardo Pantoni (4797675), Eric E Smith (5539700), François De Guio (622835), Marco Duering (562824)   +9 more
core   +1 more source

Full‐Stack Architectures for Intelligent Brain‐Computer Interfaces

Advanced Science, EarlyView.
System‐level overview of brain–computer interfaces (BCIs), illustrating the integration of neural signal acquisition, wireless transmission, and adaptive decoding. Advanced electrode, tissue interfaces, energy‐efficient communication, and robust algorithms collectively enable stable signal quality, real‐time processing, and closed‐loop operation ...
Hee Kyu Lee, Hyun Bin Kim, Sang Uk Park, Janghoon Joo, Jinhong Min, Geumbee Lee, Joohoon Kang, Hyoyoung Jeong, Jae‐Young Yoo, Sang Min Won   +9 more
wiley   +1 more source

Potential biomarkers for cerebral small vessel disease with cognitive impairment: a systematic review and meta-analysis

Frontiers in Aging Neuroscience
Cerebral small vessel disease (CSVD) is a common factor in age-related diseases such as stroke and dementia, and about half of dementia patients worldwide are caused by CSVD.
Libin Liao, Weiquan Huang, Rongchao Ma, Xuan He, Xuan He, Moxi Su, Dujuan Sha, Dujuan Sha, Dujuan Sha   +8 more
doaj   +1 more source

A Brain‐Penetrant Nanobody Reveals GSK3β‐Driven Proline‐Directed Phosphorylation as a Master Regulator of Ischemic Neurodegeneration

Advanced Science, EarlyView.
A brain‐targeted nanoparticle enables delivery of a therapeutic nanobody (Nb.29E9) that inhibits pathogenic GSK3β signaling. This intervention restores AMPK/mTORC1/TGFβ homeostasis, attenuates neuroinflammation and oxidative stress, and promotes long‐term functional recovery after ischemic stroke.
Lan Li, Muyang Li, Lei Sun, Ying Yang, Yuanshun Wu, Ziyi Yin, Anni Wang, Peiyang Zhou, Shaoxiang Luo, Jian Chen, Jun Qin, Zhibing Ai, Zilong Yuan, Zhiqiang Dong, Min Zhang   +14 more
wiley   +1 more source

Reduced myelin contributes to cognitive impairment in patients with monogenic small vessel disease [PDF]

Introduction: Myelin is pivotal for signal transfer and thus cognition. Cerebral small vessel disease (cSVD) is primarily associated with white matter (WM) lesions and diffusion changes; however, myelin alterations and related cognitive impairments in ...
Denecke, Jannis, Duering, Marco, Dewenter, Anna, Lee, Jongho, Gesierich, Benno, Franzmeier, Nicolai, Ewers, Michael, Valentim, Carolina, Kopczak, Anna, Dichgans, Martin, Pirpamer, Lukas   +10 more
core   +1 more source