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Lacunar Infarction and Small Vessel Disease: Pathology and Pathophysiology [PDF]
Journal of Stroke, 2015 Two major vascular pathologies underlie brain damage in patients with disease of small size penetrating brain arteries and arterioles; 1) thickening of the arterial media and 2) obstruction of the origins of penetrating arteries by parent artery intimal ...
Louis R Caplan
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Cerebrovascular dysfunction in cerebral small vessel disease [PDF]
, 2023 INTRODUCTION: Cerebral small vessel disease (SVD) is the cause of a quarter of all ischaemic strokes and is postulated to have a role in up to half of all dementias.
Blair, Gordon William
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Advanced Neuroimaging of Cerebral Small Vessel Disease [PDF]
Current Treatment Options in Cardiovascular Medicine, 2017 Cerebral small vessel disease (SVD) is characterised by damage to deep grey and white matter structures of the brain and is responsible for a diverse range of clinical problems that include stroke and dementia. In this review, we describe advances in neuroimaging published since January 2015, mainly with magnetic resonance imaging (MRI), that, in ...
Blair, Gordon W. +4 more
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Genetic determinants of blood lipids and cerebral small vessel disease: role of high-density lipoprotein cholesterol [PDF]
, 2020 Blood lipids are causally involved in the pathogenesis of atherosclerosis, but their role in cerebral small vessel disease remains largely elusive.
Malik, Rainer +5 more
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Research progress of cerebral small vessel disease associated with immunoinflammatory mechanisms
Chinese Journal of Contemporary Neurology and Neurosurgery, 2021 Cerebral small vessel disease (CSVD) is a type of intracranial vascular disease characterized by recurrent stroke and neurodegenerative progression. The pathogenesis of CSVD is still unclear, and immunoinflammatory mechanisms such as blood⁃brain barrier ...
ZHANG Hai⁃bo, GUO Yan⁃jun
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Genetics of Cerebral Small Vessel Disease [PDF]
Journal of Stroke, 2015 Cerebral small vessel disease (SVD) is an important cause of stroke and cognitive impairment among the elderly and is a more frequent cause of stroke in Asia than in the US or Europe. Although traditional risk factors such as hypertension or diabetes mellitus are important in the development of cerebral SVD, the exact pathogenesis is still uncertain ...
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Cerebral Small Vessel Diseases: From Vessel Alterations to Cortical Parenchymal Injury
, 2020 Cerebral Small Vessel Diseases (CSVD) represent a group of common age-related (but not clearly age-driven) microvascular brain pathologies, in which vessel injury leads to progressive accumulation of various small sized-tissue lesions (seen on ...
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Imaging scoring methods for cerebral small vessel disease
Chinese Journal of Contemporary Neurology and Neurosurgery, 2023 The pathogenesis of cerebral small vessel disease (CSVD) is not yet clear, and there is no effective treatment method at present. MRI is an important imaging in diagnosing.
PAN Xi⁃juan +2 more
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Proteostasis in Cerebral Small Vessel Disease [PDF]
Frontiers in Neuroscience, 2019 Maintaining the homeostasis of proteins (proteostasis) by controlling their synthesis, folding and degradation is a central task of cells and tissues. The gradual decline of the capacity of the various proteostasis machineries, frequently in combination with their overload through mutated, aggregation-prone proteins, is increasingly recognized as an ...
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Cerebral Venous Reflux and Dilated Basal Ganglia Perivascular Space in Hypertensive Intracerebral Hemorrhage [PDF]
Journal of Stroke, 2022 Background and Purpose Cerebral venous flow alterations potentially contribute to age-related white matter changes, but their role in small vessel disease has not been investigated. Methods This study included 297 patients with hypertensive intracerebral
Hsin-Hsi Tsai +4 more
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