Randomized, open-label, phase 1/2a study to determine the maximum tolerated dose of intraventricular sustained release nimodipine for subarachnoid hemorrhage (NEWTON [Nimodipine Microparticles to Enhance Recovery While Reducing Toxicity After Subarachnoid Hemorrhage]) [PDF]
, 2016 BACKGROUND AND PURPOSE—: We conducted a randomized, open-label, phase 1/2a, dose-escalation study of intraventricular sustained-release nimodipine (EG-1962) to determine safety, tolerability, pharmacokinetics, and clinical effects in aneurysmal ...
Aldrich, Francois +10 more
core +3 more sources
Microvascular Health as a Key Determinant of Organismal Aging
Advanced Science, EarlyView.This review spotlights the emerging field of vascular aging, providing a comprehensive and critical overview of the molecular processes and clinical manifestations of vascular dysfunction during aging. By combining basic angioscience concepts with a critical analysis of innovative pre‐clinical aging models and lifestyle interventions, it offers a ...
Mattia Cenciarini +4 more
wiley +1 more source
Commentary [Decompressive craniectomy in patients with cerebral infarction due to malignant vasospasm after aneurysmal subarachnoid hemorrhage] [PDF]
, 2012 Commentary: article "Decompressive craniectomy in patients with cerebral infarction due to malignant vasospasm after aneurysmal subarachnoid hemorrhage" on page 251 http://www.ncbi.nlm.nih.gov/pmc/articles ...
Archavlis, Eleftherios
core
Aneurysms of the intracranial segment of the ophthalmic artery trunk. case report and systematic literature review [PDF]
, 2017 Aneurysms arising from the ophthalmic artery trunk (OAT) are very rare, particularly in the artery's intracranial course. The onset of a subarachnoid hemorrhage (SAH) from a ruptured OAT aneurysm in this segment is extremely rare.
C. Colonnese +5 more
core +1 more source
Annals of Neurology, EarlyView.Objective Endovascular thrombectomy (EVT) is increasingly used for pediatric large vessel occlusion (LVO) stroke, however, its role in isolated M2 occlusions remains underexplored. This study compared clinical outcomes in children with isolated M2 occlusion treated with EVT versus best medical therapy (BMT). Methods This multicenter cohort study pooled
Peter B. Sporns +24 more
wiley +1 more source
Advances in biomarkers for vasospasm – Towards a future blood-based diagnostic test
World Neurosurgery: XObjective: Cerebral vasospasm and the resultant delayed cerebral infarction is a significant source of mortality following aneurysmal SAH. Vasospasm is currently detected using invasive or expensive imaging at regular intervals in patients following SAH,
Aditya M. Mittal +8 more
doaj +1 more source
Cell Proliferation, EarlyView.Prostate‐specific YAP1 overexpression induces pathological BPH phenogenesis. Targeting ROCK1/YAP1 with fasudil and verteporfin alleviates inflammatory BPH lesions. YAP1 orchestrates mitochondrial dysfunction and oxidative stress via suppressing SIRT1 function.
Dongxu Lin +9 more
wiley +1 more source
Verapamil use in interventional neuroradiology: A case series of postoperative pulmonary edema
Interdisciplinary Neurosurgery, 2020 Cerebral Vasospasm is a common complication of aneurysmal subarachnoid hemorrhage (aSAH) which results in delayed cerebral ischemia. Cerebral vasospasm in elective endovascular management of intracranial aneurysms rarely has been reported, and the ...
Basma Mohamed +2 more
doaj +1 more source
The Fisher Grade in predicting a degree of cerebral vasospasm in patients after intracranial aneurysm rupture [PDF]
Vojnosanitetski Pregled, 2016 Background/Aim. Intracranial aneurysms are pathological enlargement of the wall of cerebral arteries. Intracranial aneurysms rupture is a dramatic event with a significant morbidity and mortality.
Đilvesi Đula +5 more
doaj +1 more source
Cerebral vasospasm affects arterial critical closing pressure. [PDF]
, 2014 The effect of cerebral vasospasm (CVS) after aneurysmal subarachnoid hemorrhage (SAH) on critical closing pressure (CrCP) has not been fully delineated. Using cerebral impedance methodology, we sought to assess the behavior of CrCP during CVS.
Budohoski, Karol P +11 more
core +2 more sources