Advanced Materials, EarlyView.Helper and ionizable lipids play a crucial role in determining ApoE binding and subsequent liver tropism and LDLR‐mediated uptake. Ionizable lipids primarily govern the LDLR‐independent uptake pathway. This complementary interplay between lipid components ultimately governs LNP delivery performance and therapeutic efficacy in the liver.
Ashish Sarode +16 more
wiley +1 more source
Directed Navigation of Magnetotactic Bacteria via Magnetotaxis in a 3D Vasculature‐On‐A‐Chip
Advanced Materials Technologies, EarlyView.A perfusable vascular network is developed to investigate MTB at the single‐microorganism level. MTB is demonstrated to successfully align and navigate along the magnetic field inside the microvessels. Abstract Magnetotactic bacteria (MTB), inherently motile and self‐powered, are promising biorobotic candidates for targeted anti‐cancer drug delivery ...
Brianna Bradley +6 more
wiley +1 more source
Approche méthodologique de quantification de certaines veines émissaires cérébrales
Bulletins et Mémoires de la Société d’Anthropologie de Paris, 2006 Cerebral blood drainage can be studied on bone remains by measuring the diameters of the canals of the veins which cross the cranium. In this study, we propose a methodology which uses a casting method with a specific material to define the measurements ...
Béatrice Pelissier-Hermitte
doaj +1 more source
Convective infux/glymphatic system: tracers injected into the CSF enter and leave the brain along separate periarterial basement membrane pathways [PDF]
, 2018 Tracers injected into CSF pass into the brain alongside arteries and out again. This has been recently termed the "glymphatic system" that proposes tracers enter the brain along periarterial "spaces" and leave the brain along the walls of veins.
Albargothy, Nazira J. +6 more
core +1 more source
Integrin α8‐Mediated Pericyte Morphogenesis Controls Blood‐Brain Barrier Integrity
Advanced Science, EarlyView.This study highlights that ITGA8 impacts pericyte morphology and function, both crucial for BBB integrity, via RhoA/ROCK signaling, thus influencing TGF‐β1 activation through cytoskeletal tension and ECM interactions. Notably, in post‐ischemic recovery models, ITGA8 deficiency exacerbates vascular dysfunction by impairing pericyte‐mediated BBB ...
Chang‐Xiong Gong +16 more
wiley +1 more source
Perfluorocarbon Enhanced Glasgow Oxygen Level Dependent (GOLD) magnetic resonance metabolic imaging identifies the penumbra following acute ischemic stroke [PDF]
, 2018 The ability to identify metabolically active and potentially salvageable ischaemic penumbra is crucial for improving treatment decisions in acute stroke patients.
Brennan, David +5 more
core +1 more source
Prevention of cerebral thromboembolism by oral anticoagulation with dabigatran after pulmonary vein isolation for atrial fibrillation: the ODIn-AF trial [PDF]
, 2023 Jan W. Schrickel +24 more
openalex +1 more source
NARFL Knockout Triggers Ferroptosis‐Driven Vascular Endothelial Dysfunction
Advanced Science, EarlyView.NARFL is vital for CIA and oxidative stress resistance. NARFL deletion in HPMEC cells, zebrafish, and mice is lethal and rescued by a Ferroptosis inhibitor. NARFL deficiency disrupted its interaction with CIA proteins, decreased aconitase activity, increased IRP1 activity, induced Fe overload, and led to ferroptosis and oxidative stress, resulting in ...
Hui Hu +15 more
wiley +1 more source
PLoS ONE, 2013 ObjectiveMultiple sclerosis (MS) is a chronic neurodegenerative disease of the CNS. Recently a controversial vascular hypothesis for MS, termed chronic cerebrospinal venous insufficiency (CCSVI), has been advanced.
Ian W Rodger +18 more
doaj +1 more source
Churg-Strauss Syndrome with Necrosis of Toe Tips [PDF]
, 2011 Churg-Strauss syndrome (CSS) is a granulomatous necrotizing vasculitis of unknown etiology associated with bronchial asthma. Despite affecting small to medium-sized vessels, necrosis of the digits due to vasculitis is extremely rare.
Hasegawa, Kenjiro +9 more
core +1 more source