ABSTRACT Background The inflammatory response to whole‐body ischemia, as seen in comatose survivors after out‐of‐hospital cardiac arrest (OHCA), is associated with increased morbidity and mortality. Early high‐dose dexamethasone may dampen the inflammatory response, which may diminish secondary brain damage and other organ injury and decrease mortality.
Jo B. Andreasen +12 more
wiley +1 more source
Pediatric endocrine disorders: a review of intracranial findings and appropriate imaging. [PDF]
Shatadal A +3 more
europepmc +1 more source
GIP in Cardiovascular and Kidney Disease: From Physiology to Pharmacology
ABSTRACT Aims To provide a comprehensive overview of the cardiovascular and renal effects of glucose‐dependent insulinotropic polypeptide (GIP) by integrating its physiological role with recent human trial data on tirzepatide, the first dual GIP and glucagon‐like peptide‐1 (GLP‐1) receptor agonist.
Michelantonio De Fano +4 more
wiley +1 more source
Subarachnoid cisterns as surgical corridors: Integrating microsurgical anatomy and neuroimaging for intracranial navigation. [PDF]
Pérez-Carrillo N +9 more
europepmc +1 more source
Hypercortisolism: Causes, Consequences and Clinical Significance – A Review of Pathophysiology
ABSTRACT Hypercortisolism or Cushing syndrome is a heterogeneous clinical spectrum caused by chronic glucocorticoid excess, ranging from exogenous Cushing syndrome to rare endogenous aetiologies and the increasingly recognised entity of mild autonomous cortisol secretion (MACS). Physiological cortisol production is tightly regulated by the hypothalamic–
Mohamed Eldib +3 more
wiley +1 more source
Hypercortisolism: An Under‐Recognised Pathway Linked to Multi‐System Complications
ABSTRACT The clinical understanding of hypercortisolism (HC) has evolved from a classic overt syndrome with florid Cushingoid features to a broader spectrum of disease that includes milder presentations, often referred to as mild autonomous cortisol secretion (MACS).
Hernan Daniel Sacoto, Vivian A. Fonseca
wiley +1 more source
Acquired spontaneous periodic hypothermia and pancytopenia secondary to hypothalamic compression from a large skull base meningioma. [PDF]
Jolly S +5 more
europepmc +1 more source
Main design, methods, results and conclusions of the study are summarised in this central figure. ABSTRACT Background Early neuroprognostication in Out‐of‐Hospital Cardiac Arrest (OHCA) remains challenging due to the lack of reliable biomarkers. Circulating microRNAs have emerged as potential indicators of inflammation and brain injury (HIBI).
Francisco Rafael Jiménez‐Trinidad +18 more
wiley +1 more source
Long-term clinical outcomes and recurrence factors in intracranial germinoma. [PDF]
Higashino M +10 more
europepmc +1 more source
Gait Impairment and Alzheimer's Disease Pathology: A Narrative Review on Mechanistic Links
Gait impairment and AD‐related pathology may be linked through shared risks, preclinical AD changes, feedback effects of persistent gait dysfunction, and life‐course susceptibility, underscoring the importance of maintaining brain–body health across the lifespan. ABSTRACT In older adults, gait has emerged as an important indicator of overall health and
Ryota Sakurai, Manuel Montero‐Odasso
wiley +1 more source

