Results 71 to 80 of about 14,563 (162)

ROS‐ATM‐CBP axis‐mediated PARP1 lactylation aggravates doxorubicin‐induced cardiotoxicity

open access: yesClinical and Translational Medicine, Volume 16, Issue 8, August 2026.
ROS function as signalling molecules to promote CBP‐mediated PARP1 lactylation in an ATM dependent manner, which induces PARP1 PARylation and ultimate cell apoptosis. CBP and SIRT1 as specific lactyltransferase and delactylase of PARP1. Lactylation of PARP1 depends on the LDHA activity and lactate production.
Wenbin Wang, Yingxian Sun
wiley   +1 more source

Pre‐Infection COVID‐19 Vaccination and Long‐Term Cardiovascular Outcomes in Adults Without Preexisting Cardiovascular Disease: A Retrospective Cohort Study

open access: yesHealth Science Reports, Volume 9, Issue 8, August 2026.
ABSTRACT Background Long‐term cardiovascular complications after COVID‐19 are increasingly recognized, yet the protective effect of pre‐infection vaccination in individuals without prior cardiovascular disease (CVD) remains unclear. This study examined the association between COVID‐19 vaccination and major cardiovascular and related outcomes up to 3 ...
Abdul Qadeer   +11 more
wiley   +1 more source

Primary diffuse leptomeningeal glioblastoma: Report of two cases. [PDF]

open access: yesSurg Neurol Int
Saehee J   +7 more
europepmc   +1 more source

Precision Stereotactic Body Radiotherapy for Ultra‐Central NSCLC: Tailored Margins Reduce Toxicity Without Compromising Tumor Control

open access: yesMedComm, Volume 7, Issue 8, August 2026.
A tailored non‐uniform PTV strategy (including PTVcrop and PTV_high/PTV_low) was used in SBRT for ultra‐central NSCLC to meet stringent OAR constraints. Notably, this SBRT strategy achieved favorable clinical outcomes, with an 84.6% 3‐year local control rate, a median PFS of 42.9 months. Additionally, treatment‐related toxicity was mild, with only 1.5%
Di Liu   +11 more
wiley   +1 more source

Risk Factors for Cardiovascular Disease: Epidemiology, Screening, Prevention, and Therapeutic Interventions

open access: yesMedComm, Volume 7, Issue 8, August 2026.
Cardiovascular disease arises from lifelong accumulation of traditional and emerging risk factors that converge on shared pathophysiological pathways, leading to diverse clinical outcomes, and can be mitigated through integrated screening, prevention, and precision therapies. ABSTRACT Cardiovascular diseases (CVDs) remain the leading cause of morbidity
Mowei Kong   +6 more
wiley   +1 more source

Primary intracranial myxopapillary ependymoma: two case reports and literature review. [PDF]

open access: yesFront Oncol
Zhong L   +7 more
europepmc   +1 more source

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