Results 61 to 70 of about 14,293 (148)

The Challenge of Determining the Etiology of Encephalopathy in an Elderly Patient

Clinical Case Reports, Volume 14, Issue 7, July 2026.
ABSTRACT Encephalopathy is a heterogeneous clinical syndrome with numerous neurological and systemic etiologies. We report the case of a 67‐year‐old man, a chronic ethanol consumer, admitted with a one‐week history of confusional syndrome. Initial laboratory tests revealed severe hypercalcemia, acute kidney injury, mild anemia, and hyperproteinemia ...
Vlad Alexandru Ionescu, Gina Gheorghe, Roxana‐Manuela Vasile, Claudia‐Lucia Ionescu, Mihaela Bazac, Viorica Ileana Bumbea, Alina Valentina Dobrota, Ioana‐Alexandra Baban, Alexandru Barbu, Camelia Cristina Diaconu   +9 more
wiley   +1 more source

Brain Abscess Revealing an Undiagnosed Atrioventricular Septal Defect With a Common Atrium in a Young Adult

Clinical Case Reports, Volume 14, Issue 7, July 2026.
ABSTRACT Brain abscess is an uncommon but life‐threatening intracranial infection that most often arises from contiguous spread but may also occur through hematogenous dissemination in patients with congenital heart disease. This is usually associated with defects that permit right‐to‐left shunting of septic emboli.
Evans Nii Ayitey MacCready, Ama Owusuaa Kwakye, Kelvin Denanyoh, Hilda Kwapong, Isaac Nene Keteku, Jochebed Ansah, Werman Reve Robles   +6 more
wiley   +1 more source

Methotrexate‐Induced Drug Hypersensitivity Syndrome Presenting With Acute Cerebral Infarction in End‐Stage Renal Disease: A Case Report

Clinical Case Reports, Volume 14, Issue 7, July 2026.
ABSTRACT Methotrexate (MTX) is primarily renally excreted, making patients with end‐stage renal disease (ESRD) highly vulnerable to drug accumulation and toxicity. While severe drug‐induced hypersensitivity syndrome (DIHS) is a known life‐threatening adverse reaction, its association with acute central nervous system complications, specifically ...
Le Mu, Cao Yu, Jie‐Yi Shi, Zhe‐Yu Dong, Fang‐Yu Yi, Ya‐Yu Li, Shao‐Jie Zhang   +6 more
wiley   +1 more source

Olfml3 Regulates Microglial Inflammation and Neuronal Injury in Obstructive Sleep Apnea via Cybb‐Mediated TLR4/NF‐κB Pathway

CNS Neuroscience &Therapeutics, Volume 32, Issue 7, July 2026.
In obstructive sleep apnea (OSA), intermittent hypoxia (IH) induces downregulation of Olfml3 in microglial cells and inhibits the activation of microglial cells; Low Olfml3 expression leads to increased expression of the downstream gene Cybb; Cybb activates the TLR4/NF‐κB inflammatory pathway, driving microglial M1 polarization and the release of ...
Deqiu Kong, Yaowen Wang, Xianjun Chen, Cihao Hu, Bin Zhang, Xing Chen   +5 more
wiley   +1 more source

Olfactory Mucosal Mesenchymal Stem Cell‐Derived Exosomal LncA2M‐AS1 Ameliorates Parkinson's Disease by Regulating Microglial Glucose Metabolic Reprogramming and Neuroinflammation via the CFL1/ROCK1 Axis

CNS Neuroscience &Therapeutics, Volume 32, Issue 7, July 2026.
LncA2M‐AS1 targets CFL1 mRNA and destabilizes ROCK1 via ubiquitination. LncA2M‐AS1 in OM‐MSC exosomes targets CFL1 mRNA, modulating the CFL1–ROCK1 pathway to reprogram microglial glucose metabolism, suppress neuroinflammation, and ultimately protect dopaminergic neurons and reduce neuroinflammation in PD mice.
Jiangshan Zhang, Guoshuai Yang, Yanhui Zhou, Dan Hou, Chuang Wang, Yujie Hu, Ying Xia   +6 more
wiley   +1 more source

Oral Lysozyme Attenuates Neuroinflammation and Brain Injury After Traumatic Brain Injury Through Gut Microbiota‐Dependent Reprogramming of Tryptophan Metabolism

CNS Neuroscience &Therapeutics, Volume 32, Issue 7, July 2026.
Oral lysozyme reshapes gut microbiota‐dependent tryptophan metabolism, increasing neuroprotective metabolites like KYNA and restoring intestinal barrier integrity. This attenuates systemic inflammation and reprograms cerebral kynurenine metabolism toward the neuroprotective KYNA branch, reducing neuroinflammation and improving outcomes after traumatic ...
Zhuoying Du, Haijun Yao, Caihua Xi, Qiang Yuan, Pengfei Fu, Jin Hu, Gang Wu, Weijian Yang   +7 more
wiley   +1 more source

Specific Deletion of Interleukin‐1 Beta in Microglia Improves Acute Outcome and Modulates Neurogenesis After Ischemic Stroke

Glia, Volume 74, Issue 7, July 2026.
Microglial IL‐1β deletion improves acute outcome and reduces neutrophil recruitment after experimental ischemic stroke. Microglial IL‐1β deletion increases neurogenesis in the subventricular zone after experimental ischemic stroke. ABSTRACT Interleukin‐1 (IL‐1) signaling is a major driver of post‐ischemic neuroinflammation, yet the cell‐ and isoform ...
Alba Grayston, Margarida Baptista, Kelly Wemyss, Ruby Taylor, Grace Cullen, Syeda S. Jafree, Nadim Luka, Joshua R. Cox, Joanne E. Konkel, David Brough, Stuart M. Allan, Emmanuel Pinteaux   +11 more
wiley   +1 more source

Ischemia–Reperfusion Injury: Molecular Mechanisms and Therapeutic Interventions

MedComm, Volume 7, Issue 7, July 2026.
Multiorgan ischemia–reperfusion injury begins with ischemia‐induced ATP depletion and ionic imbalance, followed by reperfusion‐triggered mitochondrial ROS/RNS bursts, regulated cell death, and DAMP release. Sterile inflammation converges on endothelial–immune–coagulation crosstalk, where NETs drive immunothrombosis, no‐reflow, and remote organ injury ...
Peng An, Yi An, Mengwei Chen, Longlong Wu, Rong Wang   +4 more
wiley   +1 more source

A 57-year-old male with diffuse astrocytoma in the lateral ventricle: case report. [PDF]

BMC Neurol
Wang J, Fan Y, Zhang W.
europepmc   +1 more source

A new in silico model to precisely design focused ultrasound brain therapies

Medical Physics, Volume 53, Issue 7, July 2026.
Abstract Background Focused ultrasound (FUS) combined with microbubbles enables transient and noninvasive blood–brain barrier (BBB) opening, facilitating targeted drug delivery. However, accurate treatment planning remains difficult due to inter‐patient anatomical variability and the common assumption in simulations that brain tissues behave like water.
Allegra Conti, Marta Grossi, Patricia Cardoso De Andrade, Andrea Duggento, Nicola Toschi   +4 more
wiley   +1 more source