Results 91 to 100 of about 517,077 (303)

A Chiral Virus‐Like Nanoplatform That Broadly Mediates Antibiotic Delivery to the Brain for Bacterial Meningitis Therapy

Advanced Science, EarlyView.
Chiral virus‐mimicking mesoporous silica nanostructures (CVSNs) efficiently transport diverse antibiotics across the blood–brain barrier (BBB) into brain parenchyma and cerebrospinal fluid. By enhancing delivery to microglia and astrocytes, CVSNs improve antibiotic bioavailability and therapeutic efficacy against both Gram‐negative and Gram‐positive ...
Qianqian Xu, Xuting Zheng, Huinan Tong, Ying Liu, Xiaoxi Fan, Miao Xu, Ziyan Zhang, Li Zhang, Mingyan Liu, Ting Du, Heran Li, Guojun Liu   +11 more
wiley   +1 more source

Central nervous system involvement in a case of segmental nevus depigmentosus

Indian Journal of Paediatric Dermatology, 2016
Central nervous system involvement in segmental nevus depigmentosus (SND) is rare. A 7-month-old boy having convulsion and segmental hypopigmented patch in the right inguinal region.
Ishita Majumdar, Devdeep Mukherjee, Sandipan Dhar, Ritabrata Kundu   +3 more
doaj   +1 more source

Linear CT-scan measurements of cerebral ventricles in senile Poodle dogs. [PDF]

Braz J Vet Med, 2023
Araújo GVD, de Souza-Junior P, Viana-Peçanha S, Dos Santos-Sousa CA, Ramos MT, Bernardes FCS, Abidu-Figueiredo M.   +6 more
europepmc   +1 more source

Arhgef1 Deletion Disrupts Early Cortical Neurogenesis via PAK1 Overactivation and Causes Motor Dysfunction in Adulthood

Advanced Science, EarlyView.
ARHGEF1 plays a pivotal role in both embryonic cortical neurogenesis and adult motor function. During early development, it governs genesis of deep‐layer cortical neurons by negatively regulating RAC1/CDC42‐PAK1‐Cofilin signaling. In adulthood, ARHGEF1 is important for the maintenance of neuronal morphology and activity in the motor cortex, ensuring ...
Liuren Li, Xuanyue Ma, Zhenyu Ding, Bang Sun, Linglin Liu, Hei Matthew Yip, Wei Wang, Tianying Wu, Yuan Guo, Yinghui Peng, Shiqing Zhang, Jacque Pak Kan Ip, Li Zhang, Keshen Li, Lei Shi   +14 more
wiley   +1 more source

A role for PDGF-C/PDGFRα signaling in the formation of the meningeal basement membranes surrounding the cerebral cortex

Biology Open, 2016
Platelet-derived growth factor-C (PDGF-C) is one of three known ligands for the tyrosine kinase receptor PDGFRα. Analysis of Pdgfc null mice has demonstrated roles for PDGF-C in palate closure and the formation of cerebral ventricles, but redundancy with
Johanna Andrae, Leonor Gouveia, Radiosa Gallini, Liqun He, Linda Fredriksson, Ingrid Nilsson, Bengt R. Johansson, Ulf Eriksson, Christer Betsholtz   +8 more
doaj   +1 more source

Small Nucleus Accumbens and Large Cerebral Ventricles in Infants and Toddlers Prior to Receiving Diagnoses of Autism Spectrum Disorder. [PDF]

Cereb Cortex, 2022
Shiohama T, Ortug A, Warren JLA, Valli B, Levman J, Faja SK, Tsujimura K, Maunakea AK, Takahashi E.   +8 more
europepmc   +1 more source

Stroke‐Heart Syndrome: Mechanisms, Temporal Phenotypes, and Diagnostic Reasoning

Advanced Science, EarlyView.
Stroke‐heart syndrome describes new or worsened cardiac abnormalities after acute stroke. This Review defines its clinical boundaries, traces autonomic, inflammatory, endothelial, and supply‐demand mechanisms across time, and proposes provisional phenotypes that integrate lesion location, premorbid cardiac substrate, serial biomarkers ...
Fa Lin, Jian Lyu, Yanci Liu, Zhiyuan Feng, Jie Bao, Wenxiong Song, Bingcheng Zhu, Minghao Liu, Jionghao Xue, Jiadi Weng, Jiani Zhang, Jizong Zhao, Xiaolin Chen, Bin Dong   +13 more
wiley   +1 more source

The development of the cerebral ventricles in the pig [PDF]

American Journal of Anatomy, 1913
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openaire   +1 more source

A method for detecting molecular transport within the cerebral ventricles of live zebrafish (Danio rerio) larvae

, 2012
The production and flow of cerebrospinal fluid performs an important role in the development and homeostasis of the central nervous system. However, these processes are difficult to study in the mammalian brain because the ventricles are situated deep ...
Kay, Alan R., Ullmann, Jeremy F. P., Turner, Maxwell H.   +2 more
core   +1 more source

CKMT1 Counteracts VDAC1 Oligomerization‐Induced Neuronal Pyroptosis Through Steric Hindrance in Ischemic Stroke

Advanced Science, EarlyView.
CKMT1 inhibits VDAC1 oligomerization via a dual‐region mechanism: its NTD interacts with the VDAC1 C‐terminal domain, while residues 1–39 sterically hinder dimerization, thereby reducing mtDNA leakage and AIM2 inflammasome activation, suppressing neuronal pyroptosis and protecting against cerebral ischemic injury. ABSTRACT Ischemic stroke is one of the
Xiaoyu Wang, Sai Shi, Jianghui Wu, Jingge Zhang, Shuqin Li, Yuyan Hu, Haifeng Yin, Chenguang Zhao, Dong Ma, Xiaohui Xian, Lizhe Liu, Ling Zhao, Xiyun Liu, Zhikai Yu, Lihua Dong, Wenbin Li, Lingyan Zhang, Min Zhang   +17 more
wiley   +1 more source