Results 1 to 10 of about 2,885,993 (239)

Cerebrospinal Fluid–Basic Concepts Review

Biomedicines, 2023
Cerebrospinal fluid plays a crucial role in protecting the central nervous system (CNS) by providing mechanical support, acting as a shock absorber, and transporting nutrients and waste products.
Natalia Czarniak, Joanna Kamińska, Joanna Matowicka-Karna, Olga Martyna Koper-Lenkiewicz   +3 more
doaj   +2 more sources

Cerebrospinal Fluid Flow

Annual Review of Fluid Mechanics, 2023
Circulation of cerebrospinal fluid and interstitial fluid around the central nervous system and through the brain transports not only those water-like fluids but also any solutes they carry, including nutrients, drugs, and metabolic wastes. Passing through brain tissue primarily during sleep, this circulation has implications for neurodegenerative ...
Douglas H, Kelley, John H, Thomas
openaire   +3 more sources

Cerebrospinal fluid biomarkers measured by Elecsys assays compared to amyloid imaging [PDF]

Alzheimer's & Dementia, 2018
Levels of amyloid β peptide 42 (Aβ42), total tau, and phosphorylated tau‐181 are well‐established cerebrospinal fluid (CSF) biomarkers of Alzheimer's disease, but variability in manual plate‐based assays has limited their use.
Batrla-Utermann, Richard, Benzinger, Tammie L.S., Fagan, Anne M, Gordon, Brian A, Gray, Julia D, Holtzman, David M, Morris, John C, Quan, Marian, Schindler, Suzanne E, Wahl, Simone, Xiong, Chengjie   +10 more
core   +3 more sources

Differences Between Plasma and Cerebrospinal Fluid Glial Fibrillary Acidic Protein Levels Across the Alzheimer Disease Continuum

JAMA Neurology, 2021
Key Points Question What are the levels of plasma glial fibrillary acidic protein (GFAP) throughout the Alzheimer disease (AD) continuum, and how do they compare with the levels of cerebrospinal fluid (CSF) GFAP?
A. Benedet, M. Milà-Alomà, A. Vrillon, N. Ashton, T. Pascoal, F. Lussier, T. Karikari, C. Hourrègue, Emmanuel Cognat, J. Dumurgier, J. Stevenson, N. Rahmouni, V. Pallen, N. M. Poltronetti, G. Salvadó, M. Shekari, G. Operto, J. Gispert, C. Minguillón, K. Fauria, Gwendlyn Kollmorgen, I. Suridjan, E. Zimmer, H. Zetterberg, J. Molinuevo, C. Paquet, P. Rosa-Neto, K. Blennow, M. Suárez‐Calvet   +28 more
semanticscholar   +1 more source

Neopterin and CXCL-10 in Cerebrospinal Fluid as Potential Biomarkers of Neuroinvasive Dengue and Chikungunya

Pathogens, 2021
Dengue (DENV) and chikungunya viruses (CHIKV) cause severe neurological complications, sometimes undiagnosed. Therefore, the use of more accessible neuroinflammatory biomarkers can be advantageous considering their diagnostic and prognostic potential for
Marzia Puccioni-Sohler, Samya J. da Silva, Luiz C. S. Faria, David C. B. I. Cabral, Mauro J. Cabral-Castro   +4 more
doaj   +1 more source

Parenchymal border macrophages regulate the flow dynamics of the cerebrospinal fluid

Nature, 2022
Macrophages are important players in the maintenance of tissue homeostasis 1 . Perivascular and leptomeningeal macrophages reside near the central nervous system (CNS) parenchyma 2 , and their role in CNS physiology has not been sufficiently well studied.
Antoine Drieu, Siling Du, Steffen E. Storck, Justin Rustenhoven, Zachary Papadopoulos, Taitea Dykstra, Fenghe Zhong, Kyungdeok Kim, Susan M. Blackburn, Tornike Mamuladze, O. Harari, Celeste M. Karch, R. Bateman, R. Perrin, Martin R. Farlow, J. Chhatwal, Jared Jill Marty Bernardino Sarah Nicolas Tammie Susan V Brosch Buck Farlow Ghetti Adams Barthelemy Benzing, J. Brosch, Jill Buck, Martin R. Farlow, B. Ghetti, S. Adams, N. Barthélemy, T. Benzinger, S. Brandon, V. Buckles, Lisa Cash, Charlie Chen, J. Chua, C. Cruchaga, Darcy R. Denner, A. Dincer, Tamara Donahue, A. Fagan, B. Feldman, Shaney Flores, E. Franklin, N. Joseph-Mathurin, Alyssa R. Gonzalez, B. Gordon, Julia D. Gray, Emily Gremminger, Alexandrer Groves, Jason J Hassenstab, Cortaiga Hellm, Elizabeth M. Herries, Laura Hoechst-Swisher, D. Holtzman, Russ C. Hornbeck, Gina Jerome, S. Keefe, Deborah Koudelis, Yan Li, Jacob Marsh, Rita Martinez, K. Mawuenyega, Austin McCullough, E. McDade, J. Morris, J. Norton, Kristine E. Shady, Wendy C. Sigurdson, Jennifer C. M. Smith, Peter Wang, Qing Wang, C. Xiong, Jinbin Xu, Xiong Xu, R. Allegri, P. C. Méndez, Noelia Egido, Akihiko Araki, T. Ikeuchi, K. Ishii, K. Kasuga, Jacob Bechara, W. Brooks, P. Schofield, S. Berman, S. Goldberg, S. Ikonomovic, W. Klunk, Oscar Lopez, J. Mountz, N. Nadkarni, Riddhi Patira, Lori Smith, B. Snitz, S. Thompson, E. Weamer, Courtney A. Bodge, S. Salloway, Kathleen Carter, Duc Duong, Erik C.B. Johnson, Allan Levey, Lingyan Ping, N. Seyfried, Colleen D. Fitzpatrick, Helena Chui, J. Ringman, G. Day, N. Graff-Radford, M. Graham, Sochenda Stephens, Chrismary De La Cruz, J. Goldman, Arlene Mejia, Katie Neimeyer, James Noble, Anna Diffenbacher, Igor Yakushev, J. Levin, J. Vöglein, Jane Douglas, Nick C Fox, M. Grilo, C. Mummery, A. O’Connor, Bianca T Esposito, A. Goate, A. Renton, H. Fujii, M. Senda, H. Shimada, S. Gardener, Ralph M. Martins, H. Sohrabi, K. Taddei, Susanne Gräber‐Sultan, Lisa M. Häsler, Anna Hofmann, M. Jucker, S. Käser, Elke Kuder-Buletta, C. Laske, O. Preische, C. Haass, E. Morenas-Rodriguez, B. Nuscher, R. Ihara, Akem Nagamatsu, Y. Niimi, Clifford Jack, R. Koeppe, N. Mason, C. Masters, U. Obermüller, Song Hu, G. Randolph, I. Smirnov, J. Kipnis   +151 more
semanticscholar   +1 more source

Cerebrospinal fluid regulates skull bone marrow niches via direct access through dural channels

Nature Neuroscience, 2022
It remains unclear how immune cells from skull bone marrow niches are recruited to the meninges. Here we report that cerebrospinal fluid (CSF) accesses skull bone marrow via dura–skull channels, and CSF proteins signal onto diverse cell types within the ...
Jose A. Mazzitelli, Leon C. D. Smyth, Kevin A Cross, Taitea Dykstra, Jerry Sun, Siling Du, Tornike Mamuladze, I. Smirnov, Justin Rustenhoven, J. Kipnis   +9 more
semanticscholar   +1 more source

Cerebrospinal fluid type I interferon and cytokine profiles in enteroviral meningitis according to the presence or absence of pleocytosis

Pediatrics and Neonatology, 2021
Background: Enteroviral meningitis is typically diagnosed as the presence of pleocytosis and of viral RNA in cerebrospinal fluid. However, it was recently reported that more than 50% of infants with enteroviral meningitis diagnosed by polymerase chain ...
Kyung Yeon Lee, Jae Hee Seol, Chae Hyeon Yi, Won Hyeok Lee   +3 more
doaj   +1 more source

Cerebrospinal fluid in COVID-19: A systematic review of the literature

Journal of Neurological Sciences, 2021
Objective We sought to review the literature on cerebrospinal fluid (CSF) testing in patients with COVID-19 for evidence of viral neuroinvasion by SARS-CoV-2.
A. Lewis, J. Frontera, D. Placantonakis, J. Lighter, S. Galetta, L. Balcer, Kara R. Melmed   +6 more
semanticscholar   +1 more source

Population pharmacokinetic modeling of CSF to blood clearance: prospective tracer study of 161 patients under work-up for CSF disorders

Fluids and Barriers of the CNS, 2022
Background Quantitative measurements of cerebrospinal fluid to blood clearance has previously not been established for neurological diseases. Possibly, variability in cerebrospinal fluid clearance may affect the underlying disease process and may ...
Markus Herberg Hovd, Espen Mariussen, Hilde Uggerud, Aslan Lashkarivand, Hege Christensen, Geir Ringstad, Per Kristian Eide   +6 more
doaj   +1 more source