Results 51 to 60 of about 1,800,537 (296)

Subclinical Optic Nerve Involvement in Radiologically Isolated Syndrome: Multimodal Detection and Diagnostic Impact

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives We aimed to determine the frequency of subclinical optic nerve (ON) lesions using MRI, optical coherence tomography (OCT), and visual evoked potentials (VEP) in radiologically isolated syndrome (RIS), and to assess their diagnostic and prognostic significance.
Christine Lebrun‐Frenay, Cassandre Landes‐Château, Lydiane Mondot, Mikael Cohen, Margherita Popolo, Jérôme de Seze, Bertrand Bourre, Françoise Durand‐Dubief, Olivier Casez, Orhun H. Kantarci, Aksel Siva, Stephanie Baillif, Darin T. Okuda, Letizia Leocani   +13 more
wiley   +1 more source

ON THE REACTION OF THE CEREBROSPINAL FLUID [PDF]

Archives of Internal Medicine, 1916
In its mode of origin and in its pathways of absorption, as well as in its physical and chemical properties, the cerebrospinal fluid is unique among the body fluids. Two facts derived from clinical and experimental observations have been established within recent years with a fair degree of conclusiveness, namely, the dual origin of the cerebrospinal ...
openaire   +2 more sources

CSF concentrations of cAMP and cGMP are lower in patients with Creutzfeldt-Jakob disease but not Parkinson's disease and amyotrophic lateral sclerosis. [PDF]

, 2012
The cyclic nucleotides cyclic adenosine-3',5'-monophosphate (cAMP) and cyclic guanosine-3',5'-monophosphate (cGMP) are important second messengers and are potential biomarkers for Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS) and ...
Oeckl, Patrick, Albert C Ludolph, Hans A Kretzschmar, Ludolph, Albert C., Markus Otto, Kretzschmar, Hans A., Petra Steinacker, Stefan Lehnert, Ferger Boris, Patrick Oeckl, Otto, Markus, Ferger, Boris, Oeckl Patrick, Ludolph Albert C., Boris Ferger, Steinacker, Petra, Otto Markus, Lehnert Stefan, Steinacker Petra, Kretzschmar Hans A., Jesse, Sarah, Lehnert, Stefan, Sarah Jesse, Jesse Sarah   +23 more
core   +1 more source

T1 Over Squared Proton Density Ratio to Characterize Multiple Sclerosis Lesions

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Differentiating remyelinated from demyelinated lesions in MS remains challenging without histological confirmation. This study introduces the T1‐to‐PD2 ratio (TPR) imaging approach and evaluates its ability to characterize MS lesions alongside other quantitative MRI (qMRI) metrics. Methods Thirty individuals with MS (mean age: 47.5 ± 
Sarah J. Wright, Scotty G. McKay, Jean Ramos Bou, Fen Bao, Vivian B. Truong, Chenyang Li, Li Jiang, Anza B. Memon, E. Mark Haacke, Yulin Ge, Yongsheng Chen   +10 more
wiley   +1 more source

Reference values for intracranial pressure and lumbar cerebrospinal fluid pressure: a systematic review

Fluids and Barriers of the CNS, 2021
Background Although widely used in the evaluation of the diseased, normal intracranial pressure and lumbar cerebrospinal fluid pressure remain sparsely documented. Intracranial pressure is different from lumbar cerebrospinal fluid pressure.
Nicolas Hernandez Norager, Markus Harboe Olsen, Sarah Hornshoej Pedersen, Casper Schwartz Riedel, Marek Czosnyka, Marianne Juhler   +5 more
doaj   +1 more source

Cognitive and Neuroimaging Divergence Between Juvenile and Adult FUS Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by progressive motor neuron degeneration. Fused in sarcoma (FUS)‐associated juvenile ALS (jALS) represents a distinct and aggressive subgroup with rapid deterioration and poor prognosis.
Alexandra V. Jürs, Marcel Naumann, Annaliis Lehto, Hanna Schön, Jens Kurth, Johannes Prudlo, Andreas Hermann, Elisabeth Kasper   +7 more
wiley   +1 more source

Alzheimer's Disease Biomarkers Measured by Capillary Blood Collection Versus Venous Plasma and Cerebrospinal Fluid [PDF]

Ann Clin Transl Neurol
ABSTRACT Objective Blood biomarkers are increasingly critical for non‐invasive Alzheimer's Disease (AD) diagnostics and research but typically require on‐site processing. Remote point‐of‐care collection methods could enhance biomarker testing in clinical and research settings.
Ho S, Shen Z, Lewis A, Patel M, Zheng A, Proscino G, Ho T, Wang J, Albert M, Moghekar A.   +9 more
europepmc   +2 more sources

Digital Cognitive Phenotyping for Differential Diagnosis and Monitoring in Neurological Conditions

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To assess the utility, accessibility, and equivalence to supervised scales of online cognitive assessment in older individuals with cognitive impairment. Methods Patients with Alzheimer's disease (AD, n = 31), idiopathic normal pressure hydrocephalus (iNPH, n = 26), and traumatic brain injury (TBI, n = 23) completed online cognitive ...
Martina Del Giovane, Valentina Giunchiglia, Michael C. B. David, Magdalena A. Kolanko, William R. Trender, Peter J. Hellyer, Harmeena Kaur, David J. Sharp, Christopher Carswell, Paresh A. Malhotra, Adam Hampshire   +10 more
wiley   +1 more source

Application of MGMT Promoter Methylation of Cerebrospinal Fluid in Diagnosis of Glioma

Zhongliu Fangzhi Yanjiu, 2018
Objective To compare the sensitivity and specificity of O6-methylguanine-DNA methyltransferase(MGMT) promoter methylation between peripheral blood and cerebrospinal fluid in the initial diagnosis of glioma patients. Methods We collected the tumor tissues,
WANG Long, HUANG Caifei, GE Jian, CHEN Zhibiao, CAI Qiang, LIU Baohui, CHEN Qianxue   +6 more
doaj   +1 more source

Analytical performance and clinical utility of the INNOTEST (R) PHOSPHO-TAU(181P) assay for discrimination between Alzheimer's disease and dementia with Lewy bodies [PDF]

, 2006
Background: Total tau (T-tau) and beta-amyloid((1-42)) (A beta(1-42)) levels in cerebrospinal fluid (CSF) can differentiate Alzheimer's disease (AD) from normal aging or depressive pseudo-dementia.
Bläser, Miriam, Blennow, Kaj,, Vanderstichele, Hugo, Bürger, Katharina, Karen De Vreese, Anari, Lessia, Olsson, Annika Ohrfelt, Miriam Bläser, OLSSON AO, BLASER M, Eugeen Vanmechelen, Harald Hampel, DiLuca, Monica, BURGER K, ANDREASEN N, Christian Sindic, Niels Andreasen, Vanmechelen, Eugeen, Frank Hulstaert, PARNETTI L, LANARI A, VANDERSTICHELE H, Andreasen, Niels, DILUCA M, Katharina Bürger, Pottel, Hans, Öhrfelt Olsson, Annika,, Lanari, Alessia, Parnetti, Lucilla, DE VREESE K, Sindic, Christian, Hulstaert, Frank, Buerger, Katharina, PADOVANI, Alessandro, Monica DiLuca, De Vreese, Karen, Kaj Blennow, Ivanoiu, Adrian, POTTEL H, Padovani, Allesandro, BLENNOW K, Lucilla Parnetti, Annika Ohrfelt Olsson, Hans Pottel, HAMPEL H, Alessia Lanari, Allesandro Padovani, Hampel, Harald, Hugo Vanderstichele, SINDIC C, IVANOIU A, VANMECHELEN E., Blennow, Kaj, HULSTAERT F, Adrian Ivanoiu, Blennow, K, Lanari, A, Parnetti, L, Hampel, H, De, Vreese K, Andreasen, N,, Sindic, C, Vanderstichele, H, Ivanoiu, A, Buerger, K   +64 more
core   +2 more sources