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Role of CD36 in central nervous system diseases [PDF]
Neural Regeneration Research, 2023 CD36 is a highly glycosylated integral membrane protein that belongs to the scavenger receptor class B family and regulates the pathological progress of metabolic diseases.
Min Feng +7 more
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Lactylation and Central Nervous System Diseases [PDF]
Brain SciencesAs the final product of glycolysis, lactate serves as an energy substrate, metabolite, and signaling molecule in various diseases and mediates lactylation, an epigenetic modification that occurs under both physiological and pathological conditions ...
Ye Chen, Dongqiong Xiao, Xihong Li
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Copper homeostasis and cuproptosis in central nervous system diseases [PDF]
Cell Death and DiseaseCopper (Cu), an indispensable micronutrient for the sustenance of living organisms, contributes significantly to a vast array of fundamental metabolic processes.
Zhipeng Zhu +5 more
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Microglia lactylation in relation to central nervous system diseases [PDF]
Neural Regeneration ResearchThe development of neurodegenerative diseases is closely related to the disruption of central nervous system homeostasis. Microglia, as innate immune cells, play important roles in the maintenance of central nervous system homeostasis, injury response ...
Hui Yang +7 more
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Antibody-mediated central nervous system diseases [PDF]
Brain and Neuroscience Advances, 2018 Antibody-mediated central nervous system diseases are a relatively new area of clinical neuroscience with growing impact. Their recognition has challenged the dogma of the blood–brain barrier preventing antibody access into the central nervous system ...
Maria Pia Giannoccaro +2 more
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NLRP3 inflammasome in neuroinflammation and central nervous system diseases. [PDF]
Cell Mol ImmunolNeuroinflammation plays an important role in the pathogenesis of various central nervous system (CNS) diseases. The NLRP3 inflammasome is an important intracellular multiprotein complex composed of the innate immune receptor NLRP3, the adaptor protein ...
Xu W, Huang Y, Zhou R.
europepmc +2 more sources
The blood-brain barriers: novel nanocarriers for central nervous system diseases. [PDF]
J NanobiotechnologyThe central nervous system (CNS) diseases are major contributors to death and disability worldwide. However, the blood–brain barrier (BBB) often prevents drugs intended for CNS diseases from effectively crossing into the brain parenchyma to deliver their
Liu J, Wang T, Dong J, Lu Y.
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Phosphatidylserine, inflammation, and central nervous system diseases
Frontiers in Aging Neuroscience, 2022 Phosphatidylserine (PS) is an anionic phospholipid in the eukaryotic membrane and is abundant in the brain. Accumulated studies have revealed that PS is involved in the multiple functions of the brain, such as activation of membrane signaling pathways ...
Xiaohua Ma +7 more
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Role of Exosomes in Central Nervous System Diseases
Frontiers in Molecular Neuroscience, 2019 There are many types of intercellular communication, and extracellular vesicles are one of the important forms of this. They are released by a variety of cell types, are heterogeneous, and can roughly be divided into microvesicles and exosomes according ...
Wanying Liu +12 more
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Meningeal Lymphatics in Central Nervous System Diseases. [PDF]
Annu Rev NeurosciSince its recent discovery, the meningeal lymphatic system has reshaped our understanding of central nervous system (CNS) fluid exchange, waste clearance, immune cell trafficking, and immune privilege.
Salvador AFM, Abduljawad N, Kipnis J.
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