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Translational Psychiatry, 2023 Cognitive impairment is a core feature of schizophrenia and is poorly addressed by currently available medication. This is partly because the underlying circuits are insufficiently understood, and available animal models for brain dysfunction do not ...
Oana-Daniela Dormann +2 more
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Paraneoplastic Diseases of the Central Nervous System [PDF]
F1000Research, 2020 Paraneoplastic neurological syndromes are nonmetastatic complications of malignancy secondary to immune-mediated neuronal dysfunction or death. Pathogenesis may occur from cell surface binding of antineuronal antibodies leading to dysfunction of the target protein, or from antibodies binding against intracellular antigens which ultimately leads to cell
Jonathan Galli, John Greenlee
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Cell Death and Disease, 2021 Glioblastoma multiforme (GBM) is an extremely aggressive brain tumor for which new therapeutic approaches are urgently required. Unfolded protein response (UPR) plays an important role in the progression of GBM and is a promising target for developing ...
Guanzheng Liu +13 more
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Frontiers in Immunology, 2021 Tocilizumab, a humanized anti-IL-6 receptor monoclonal antibody, showed its therapeutic efficacy on neuromyelitis optica spectrum disorder (NMOSD).
Ye Liu +12 more
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Exploration of cerebral vasospasm from the perspective of microparticles
Frontiers in Neuroscience, 2022 Cerebral vasospasm is a frequently encountered clinical problem, especially in patients with traumatic brain injury and subarachnoid hemorrhage. Continued cerebral vasospasm can cause cerebral ischemia, even infarction and delayed ischemic neurologic ...
Yalong Gao +7 more
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Viral diseases of the central nervous system [PDF]
Current Opinion in Virology, 2015 Virus-induced diseases of the central nervous system (CNS) represent a significant burden to human health worldwide. The complexity of these diseases is influenced by the sheer number of different neurotropic viruses, the diverse routes of CNS entry, viral tropism, and the immune system.
Phillip A, Swanson, Dorian B, McGavern
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Glucose metabolism: A link between traumatic brain injury and Alzheimer’s disease
Chinese Journal of Traumatology, 2021 Traumatic brain injury (TBI), a growing public health problem, is a leading cause of death and disability worldwide, although its prevention measures and clinical cares are substantially improved.
Xiao-Jian Xu +5 more
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Phosphatidylserine, inflammation, and central nervous system diseases
Frontiers in Aging Neuroscience, 2022 Phosphatidylserine (PS) is an anionic phospholipid in the eukaryotic membrane and is abundant in the brain. Accumulated studies have revealed that PS is involved in the multiple functions of the brain, such as activation of membrane signaling pathways ...
Xiaohua Ma +7 more
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[Role of succinylation modification in central nervous system diseases]. [PDF]
Zhong Nan Da Xue Xue Bao Yi Xue BanGu M, Ren K, Zhang Z, Chen X.
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Nanomedicine strategies for central nervous system (CNS) diseases
Frontiers in Biomaterials Science, 2023 The blood-brain barrier (BBB) is a crucial part of brain anatomy as it is a specialized, protective barrier that ensures proper nutrient transport to the brain, ultimately leading to regulating proper brain function.
Shreya Nagri, Olivia Rice, Yupeng Chen
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