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Lactylation and Central Nervous System Diseases [PDF]

Brain Sciences
As the final product of glycolysis, lactate serves as an energy substrate, metabolite, and signaling molecule in various diseases and mediates lactylation, an epigenetic modification that occurs under both physiological and pathological conditions ...
Ye Chen, Dongqiong Xiao, Xihong Li
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Antibody-mediated central nervous system diseases [PDF]

Brain and Neuroscience Advances, 2018
Antibody-mediated central nervous system diseases are a relatively new area of clinical neuroscience with growing impact. Their recognition has challenged the dogma of the blood–brain barrier preventing antibody access into the central nervous system ...
Maria Pia Giannoccaro, Sarah J. Crisp, Angela Vincent   +2 more
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A Review on Lactoferrin and Central Nervous System Diseases

Cells, 2021
Central nervous system (CNS) diseases are currently one of the major health issues around the world. Most CNS disorders are characterized by high oxidative stress levels and intense inflammatory responses in affected tissues.
Yu-Qi Li, Chuang Guo
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Oral microbiota and central nervous system diseases: A review [PDF]

Neuroprotection
Oral microbiota is the second largest microbial colony in the body and forms a complex ecological community that influences oral and brain health. Impaired homeostasis of the oral microbiota can lead to pathological changes, resulting in central nervous ...
Xiaoxuan Zhang, Mengmeng Zhong, Yang Li, Hui Wang, Guangjun Xi, Feng Wang, Chao Cheng, Yachen Shi   +7 more
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Neurosurgical gene therapy for central nervous system diseases [PDF]

Neurotherapeutics
Viral vector mediated gene therapies for neurodegenerative and neurodevelopmental conditions that require neurosurgical administration continue to expand.
Ruchit V. Patel, Pranav Nanda, R. Mark Richardson   +2 more
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Copper homeostasis and cuproptosis in central nervous system diseases [PDF]

Cell Death and Disease
Copper (Cu), an indispensable micronutrient for the sustenance of living organisms, contributes significantly to a vast array of fundamental metabolic processes.
Zhipeng Zhu, Min Song, Jianxun Ren, Lirong Liang, Guohua Mao, Min Chen   +5 more
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TREK-1 in central nervous system diseases [PDF]

Chinese Medical Journal
Man Chen, Yile Wang, Zhen Xiong, Yongkang Fang, Zhou Zhu, Ting Gao   +5 more
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Mitochondrion-based organellar therapies for central nervous system diseases [PDF]

Cell Communication and Signaling
As most traditional drugs used to treat central nervous system (CNS) diseases have a single therapeutic target, many of them cannot treat complex diseases or diseases whose mechanism is unknown and cannot effectively reverse the root changes underlying ...
Mengke Zhao, Jiayi Wang, Shuaiyu Zhu, Meina Wang, Chong Chen, Liang Wang, Jing Liu   +6 more
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Piezo1: the key regulators in central nervous system diseases [PDF]

Frontiers in Cellular Neuroscience
The occurrence and development of central nervous system (CNS) diseases is a multi-factor and multi-gene pathological process, and their diagnosis and treatment have always posed a serious challenge in the medical field. Therefore, exploring the relevant
Yi Xu, Yuheng Wang, Yanling Yang, Xiaowei Fang, Lidong Wu, Jialing Hu, Jin Li, Shuchong Mei   +7 more
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Extracellular particles: emerging insights into central nervous system diseases [PDF]

Journal of Nanobiotechnology
Extracellular particles (EPs), including extracellular vesicles (EVs) and non-vesicular extracellular particles (NVEPs), are multimolecular biomaterials released by cells that play a crucial role in intercellular communication.
Shenyuan Chen, Qinghua Bao, Wenrong Xu, Xiao Zhai   +3 more
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