Results 11 to 20 of about 651,707 (212)

Lactylation and Central Nervous System Diseases [PDF]

Brain Sciences
As the final product of glycolysis, lactate serves as an energy substrate, metabolite, and signaling molecule in various diseases and mediates lactylation, an epigenetic modification that occurs under both physiological and pathological conditions ...
Ye Chen, Dongqiong Xiao, Xihong Li
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KAT5: the epigenetic regulator of central nervous system diseases [PDF]

Frontiers in Molecular Neuroscience
Abnormal epigenetic modifications are involved in central nervous system (CNS) diseases. Histones play a crucial role in chromatin structure and function, whose post-translational modifications significantly impact gene expression and chromatin dynamics.
Xiaoming Xin, Lingjuan Wu, Meichen Liu, Tian Liu, Zihan Yuan, Liang Zhang, Tongqing Duan, Lei Zhang, Xianmin Zhu   +8 more
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Oral microbiota and central nervous system diseases: A review [PDF]

Neuroprotection
Oral microbiota is the second largest microbial colony in the body and forms a complex ecological community that influences oral and brain health. Impaired homeostasis of the oral microbiota can lead to pathological changes, resulting in central nervous ...
Xiaoxuan Zhang, Mengmeng Zhong, Yang Li, Hui Wang, Guangjun Xi, Feng Wang, Chao Cheng, Yachen Shi   +7 more
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TREK-1 in central nervous system diseases [PDF]

Chinese Medical Journal
Man Chen, Yile Wang, Zhen Xiong, Yongkang Fang, Zhou Zhu, Ting Gao   +5 more
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Copper homeostasis and cuproptosis in central nervous system diseases [PDF]

Cell Death and Disease
Copper (Cu), an indispensable micronutrient for the sustenance of living organisms, contributes significantly to a vast array of fundamental metabolic processes.
Zhipeng Zhu, Min Song, Jianxun Ren, Lirong Liang, Guohua Mao, Min Chen   +5 more
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Piezo1: the key regulators in central nervous system diseases [PDF]

Frontiers in Cellular Neuroscience
The occurrence and development of central nervous system (CNS) diseases is a multi-factor and multi-gene pathological process, and their diagnosis and treatment have always posed a serious challenge in the medical field. Therefore, exploring the relevant
Yi Xu, Yuheng Wang, Yanling Yang, Xiaowei Fang, Lidong Wu, Jialing Hu, Jin Li, Shuchong Mei   +7 more
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Brainstem syndrome at onset is related to an early MS diagnosis in Peru: A national referral center cohort

Heliyon, 2021
Background: MS is unpredictable regarding clinical symptoms; however, certain symptoms represent the preferred localization of white matter lesions such as brainstem, spinal cord; or optic nerve.
César Caparó-Zamalloa, Sheila Castro-Suarez, Jaqueline Cortez-Escalante, Wilfor Aguirre-Quispe, Erik Guevara-Silva, Victor Osorio-Marcatinco, María Meza-Vega   +6 more
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Effects of the mGlu2/3 receptor agonist LY379268 on two models of disturbed auditory evoked brain oscillations in mice

Translational Psychiatry, 2023
Cognitive impairment is a core feature of schizophrenia and is poorly addressed by currently available medication. This is partly because the underlying circuits are insufficiently understood, and available animal models for brain dysfunction do not ...
Oana-Daniela Dormann, Niklas Schuelert, Holger Rosenbrock   +2 more
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RETRACTED ARTICLE: GRP78 determines glioblastoma sensitivity to UBA1 inhibition-induced UPR signaling and cell death

Cell Death and Disease, 2021
Glioblastoma multiforme (GBM) is an extremely aggressive brain tumor for which new therapeutic approaches are urgently required. Unfolded protein response (UPR) plays an important role in the progression of GBM and is a promising target for developing ...
Guanzheng Liu, Jiefeng Yu, Runqiu Wu, Lin Shi, Xu Zhang, Wanhong Zhang, Xiaomin Zhong, Yifeng Wang, Huan Li, Yang Shen, Changyong Wu, Rutong Yu, Mingshan Niu, Xuejiao Liu   +13 more
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Effects of Tocilizumab Therapy on Circulating B Cells and T Helper Cells in Patients With Neuromyelitis Optica Spectrum Disorder

Frontiers in Immunology, 2021
Tocilizumab, a humanized anti-IL-6 receptor monoclonal antibody, showed its therapeutic efficacy on neuromyelitis optica spectrum disorder (NMOSD).
Ye Liu, Huiming Zhang, Tian-Xiang Zhang, Meng Yuan, Chen Du, Pei Zeng, Zhenning Huang, Dongmei Jia, Guili Yang, Fu-Dong Shi, Fu-Dong Shi, Chao Zhang, Chao Zhang   +12 more
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