Results 11 to 20 of about 647,830 (291)

Treatment update for autoimmune/immune-mediated central nervous system diseases

Folia Neuropathologica
Autoimmune/immune-mediated central nervous system (CNS) diseases are chronic, inflammatory, autoimmune diseases, such as multiple sclerosis (MS), neuromyelitis optica spectrum disorder (NMOSD), and autoimmune encephalitis (AE).
Jiayi Wu, Xuewei Li, Jun Peng, Wan Fu, Shuangxi Chen, Heng Wu   +5 more
doaj   +2 more sources

Central nervous system manifestations in rheumatic diseases [PDF]

Journal of Medical Biochemistry, 2011
Neurological involvement is associated with significant morbidity in patients with rheumatic diseases, and may indicate heightened disease activity. Connective tissue diseases result from immunologic or autoimmune reactions.
Cojocaru Mihaela Inimioara, Cojocaru Manole, Silosi Isabela, Vrabie Doina Camelia   +3 more
doaj   +2 more sources

Spectrum of acute central nervous system demyelinating diseases [PDF]

Perspectives In Medical Research, 2017
Central nervous system(CNS) demyelinative diseases are mainly Multiple Sclerosis, Acute Disseminated Encephalomyelitis (ADEM), Acute hemorrhagic Leucoencephalitis (AHL). Multiple Sclerosis is the most common.
Bharathkanth Reddy M1 , Ranjith Kumar P2 , P.L John Israel3
doaj   +1 more source

Microglia lactylation in relation to central nervous system diseases [PDF]

Neural Regeneration Research
The development of neurodegenerative diseases is closely related to the disruption of central nervous system homeostasis. Microglia, as innate immune cells, play important roles in the maintenance of central nervous system homeostasis, injury response ...
Hui Yang, Nan Mo, Le Tong, Jianhong Dong, Ziwei Fan, Mengxian Jia, Juanqing Yue, Ying Wang   +7 more
doaj   +2 more sources

Brainstem syndrome at onset is related to an early MS diagnosis in Peru: A national referral center cohort

Heliyon, 2021
Background: MS is unpredictable regarding clinical symptoms; however, certain symptoms represent the preferred localization of white matter lesions such as brainstem, spinal cord; or optic nerve.
César Caparó-Zamalloa, Sheila Castro-Suarez, Jaqueline Cortez-Escalante, Wilfor Aguirre-Quispe, Erik Guevara-Silva, Victor Osorio-Marcatinco, María Meza-Vega   +6 more
doaj   +1 more source

Peptidylarginine deiminases and extracellular vesicles: prospective drug targets and biomarkers in central nervous system diseases and repair. [PDF]

, 2021
Peptidylarginine deiminases are a family of calcium-activated enzymes with multifaceted roles in physiological and pathological processes, including in the central nervous system.
Lange, Sigrun
core   +1 more source

Effects of the mGlu2/3 receptor agonist LY379268 on two models of disturbed auditory evoked brain oscillations in mice

Translational Psychiatry, 2023
Cognitive impairment is a core feature of schizophrenia and is poorly addressed by currently available medication. This is partly because the underlying circuits are insufficiently understood, and available animal models for brain dysfunction do not ...
Oana-Daniela Dormann, Niklas Schuelert, Holger Rosenbrock   +2 more
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Paraneoplastic Diseases of the Central Nervous System [PDF]

F1000Research, 2020
Paraneoplastic neurological syndromes are nonmetastatic complications of malignancy secondary to immune-mediated neuronal dysfunction or death. Pathogenesis may occur from cell surface binding of antineuronal antibodies leading to dysfunction of the target protein, or from antibodies binding against intracellular antigens which ultimately leads to cell
Jonathan Galli, John Greenlee
openaire   +2 more sources

RETRACTED ARTICLE: GRP78 determines glioblastoma sensitivity to UBA1 inhibition-induced UPR signaling and cell death

Cell Death and Disease, 2021
Glioblastoma multiforme (GBM) is an extremely aggressive brain tumor for which new therapeutic approaches are urgently required. Unfolded protein response (UPR) plays an important role in the progression of GBM and is a promising target for developing ...
Guanzheng Liu, Jiefeng Yu, Runqiu Wu, Lin Shi, Xu Zhang, Wanhong Zhang, Xiaomin Zhong, Yifeng Wang, Huan Li, Yang Shen, Changyong Wu, Rutong Yu, Mingshan Niu, Xuejiao Liu   +13 more
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Effects of Tocilizumab Therapy on Circulating B Cells and T Helper Cells in Patients With Neuromyelitis Optica Spectrum Disorder

Frontiers in Immunology, 2021
Tocilizumab, a humanized anti-IL-6 receptor monoclonal antibody, showed its therapeutic efficacy on neuromyelitis optica spectrum disorder (NMOSD).
Ye Liu, Huiming Zhang, Tian-Xiang Zhang, Meng Yuan, Chen Du, Pei Zeng, Zhenning Huang, Dongmei Jia, Guili Yang, Fu-Dong Shi, Fu-Dong Shi, Chao Zhang, Chao Zhang   +12 more
doaj   +1 more source