Results 21 to 30 of about 1,580,164 (331)
Translational Psychiatry, 2023 Cognitive impairment is a core feature of schizophrenia and is poorly addressed by currently available medication. This is partly because the underlying circuits are insufficiently understood, and available animal models for brain dysfunction do not ...
Oana-Daniela Dormann +2 more
doaj +1 more source
Astrocytes in human central nervous system diseases: a frontier for new therapies
Signal Transduction and Targeted Therapy, 2023 Astroglia are a broad class of neural parenchymal cells primarily dedicated to homoeostasis and defence of the central nervous system (CNS). Astroglia contribute to the pathophysiology of all neurological and neuropsychiatric disorders in ways that can ...
Alexei Verkhratsky +7 more
semanticscholar +1 more source
Cell Death and Disease, 2021 Glioblastoma multiforme (GBM) is an extremely aggressive brain tumor for which new therapeutic approaches are urgently required. Unfolded protein response (UPR) plays an important role in the progression of GBM and is a promising target for developing ...
Guanzheng Liu +13 more
doaj +1 more source
Frontiers in Immunology, 2021 Tocilizumab, a humanized anti-IL-6 receptor monoclonal antibody, showed its therapeutic efficacy on neuromyelitis optica spectrum disorder (NMOSD).
Ye Liu +12 more
doaj +1 more source
ACSL4-Mediated Ferroptosis and Its Potential Role in Central Nervous System Diseases and Injuries
International Journal of Molecular Sciences, 2023 As an iron-dependent regulated form of cell death, ferroptosis is characterized by iron-dependent lipid peroxidation and has been implicated in the occurrence and development of various diseases, including nervous system diseases and injuries ...
B. Jia +3 more
semanticscholar +1 more source
Exploration of cerebral vasospasm from the perspective of microparticles
Frontiers in Neuroscience, 2022 Cerebral vasospasm is a frequently encountered clinical problem, especially in patients with traumatic brain injury and subarachnoid hemorrhage. Continued cerebral vasospasm can cause cerebral ischemia, even infarction and delayed ischemic neurologic ...
Yalong Gao +7 more
doaj +1 more source
Aging and Disease, 2023 The metabolism of L-tryptophan (TRP) regulates homeostasis, immunity, and neuronal function. Altered TRP metabolism has been implicated in the pathophysiology of various diseases of the central nervous system. TRP is metabolized through two main pathways,
Yinrou Huang +12 more
semanticscholar +1 more source
Glucose metabolism: A link between traumatic brain injury and Alzheimer’s disease
Chinese Journal of Traumatology, 2021 Traumatic brain injury (TBI), a growing public health problem, is a leading cause of death and disability worldwide, although its prevention measures and clinical cares are substantially improved.
Xiao-Jian Xu +5 more
doaj +1 more source
The role of gamma oscillations in central nervous system diseases: Mechanism and treatment
Frontiers in Cellular Neuroscience, 2022 Gamma oscillation is the synchronization with a frequency of 30–90 Hz of neural oscillations, which are rhythmic electric processes of neuron groups in the brain.
Ao Guan +8 more
semanticscholar +1 more source
CNS Neuroscience & Therapeutics, 2023 Mitochondria is one of the important organelles involved in cell energy metabolism and regulation and also play a key regulatory role in abnormal cell processes such as cell stress, cell damage, and cell canceration.
Zi’ang Geng +6 more
semanticscholar +1 more source