Results 21 to 30 of about 24,516,016 (295)
Targeting sialylation to treat central nervous system diseases. [PDF]
, 2021 Sialic acid-binding immunoglobulin-type lectins (SIGLECs) are membrane receptors that are preferentially expressed on immune cells and recognize sialylated proteins, lipids, and RNA.
Neumann, Harald +2 more
core +2 more sources
Paraneoplastic Diseases of the Central Nervous System [PDF]
F1000Research, 2020 Paraneoplastic neurological syndromes are nonmetastatic complications of malignancy secondary to immune-mediated neuronal dysfunction or death. Pathogenesis may occur from cell surface binding of antineuronal antibodies leading to dysfunction of the target protein, or from antibodies binding against intracellular antigens which ultimately leads to cell
Jonathan Galli, John Greenlee
openaire +2 more sources
Heliyon, 2021 Background: MS is unpredictable regarding clinical symptoms; however, certain symptoms represent the preferred localization of white matter lesions such as brainstem, spinal cord; or optic nerve.
César Caparó-Zamalloa +6 more
doaj +1 more source
Translational Psychiatry, 2023 Cognitive impairment is a core feature of schizophrenia and is poorly addressed by currently available medication. This is partly because the underlying circuits are insufficiently understood, and available animal models for brain dysfunction do not ...
Oana-Daniela Dormann +2 more
doaj +1 more source
Peptidylarginine deiminases and extracellular vesicles: prospective drug targets and biomarkers in central nervous system diseases and repair. [PDF]
, 2021 Peptidylarginine deiminases are a family of calcium-activated enzymes with multifaceted roles in physiological and pathological processes, including in the central nervous system.
Lange, Sigrun
core +1 more source
Cell Death and Disease, 2021 Glioblastoma multiforme (GBM) is an extremely aggressive brain tumor for which new therapeutic approaches are urgently required. Unfolded protein response (UPR) plays an important role in the progression of GBM and is a promising target for developing ...
Guanzheng Liu +13 more
doaj +1 more source
Frontiers in Immunology, 2021 Tocilizumab, a humanized anti-IL-6 receptor monoclonal antibody, showed its therapeutic efficacy on neuromyelitis optica spectrum disorder (NMOSD).
Ye Liu +12 more
doaj +1 more source
Exploration of cerebral vasospasm from the perspective of microparticles
Frontiers in Neuroscience, 2022 Cerebral vasospasm is a frequently encountered clinical problem, especially in patients with traumatic brain injury and subarachnoid hemorrhage. Continued cerebral vasospasm can cause cerebral ischemia, even infarction and delayed ischemic neurologic ...
Yalong Gao +7 more
doaj +1 more source
Viral diseases of the central nervous system [PDF]
Current Opinion in Virology, 2015 Virus-induced diseases of the central nervous system (CNS) represent a significant burden to human health worldwide. The complexity of these diseases is influenced by the sheer number of different neurotropic viruses, the diverse routes of CNS entry, viral tropism, and the immune system.
Phillip A, Swanson, Dorian B, McGavern
openaire +2 more sources
Glucose metabolism: A link between traumatic brain injury and Alzheimer’s disease
Chinese Journal of Traumatology, 2021 Traumatic brain injury (TBI), a growing public health problem, is a leading cause of death and disability worldwide, although its prevention measures and clinical cares are substantially improved.
Xiao-Jian Xu +5 more
doaj +1 more source