Results 61 to 70 of about 251,924 (301)

Elevated cerebral spinal fluid biomarkers in children with mucopolysaccharidosis I-H. [PDF]

, 2016
Mucopolysaccharidosis (MPS) type-IH is a lysosomal storage disease that results from mutations in the IDUA gene causing the accumulation of glycosaminoglycans (GAGs).
Dickson, Patricia I, Lund, Troy C, Miller, Weston P, Orchard, Paul J, Pasquali, Marzia, Polgreen, Lynda E, Raymond, Gerald V   +6 more
core   +1 more source

Clinical Characteristics and Outcomes of Early‐Onset Versus Late‐Onset LGI1‐Antibody Encephalitis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Leucine‐rich glioma‐inactivated 1 antibody (LGI1‐Ab) encephalitis predominantly affected older individuals, but has also been reported in younger patients. However, the demographic, clinical, and prognostic characteristics of early‐onset LGI1‐Ab encephalitis have yet to be systematically elucidated. This study aims to systematically
Yu Kong, Shasha Yu, Jing Zhang, Yu Zu, Yujing Zhang, Jing Lv, Xuyang Cao, Xuedan Feng   +7 more
wiley   +1 more source

A Systematic Review of Cases of Meningitis in the Absence of Cerebrospinal Fluid Pleocytosis on Lumbar Puncture [PDF]

, 2019
Background: Definitive diagnosis of meningitis is made by analysis of cerebrospinal fluid (CSF) culture or polymerase chain reaction (PCR) obtained from a lumbar puncture (LP), which may take days.
Pettigrew, Alexis, Troendle, Michelle
core   +1 more source

Cryptococcal infection of the ventriculoperitoneal shunt in an immunocompetent patient [PDF]

, 2016
Patient: Male, 52 Final Diagnosis: Cryptococcal ventriculoperitoneal shunt infection Symptoms: Confusion • fever • Lethargy Medication: Amphotericin B • Flucytosine Clinical Procedure: Ventriculoperitoneal shunt removal Specialty: Infectious disease ...
Foong, Kap Sum, Lee, Ashley, Vasquez, Gustavo   +2 more
core   +2 more sources

Plasma Proteomic Signatures for Alzheimer's Disease: Comparable Accuracy to ATN Biomarkers and Cross‐Platform Validation

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background There is growing recognition of the potential of plasma proteomics for Alzheimer's Disease (AD) risk assessment and disease characterization. However, differences between proteomics platforms introduce uncertainties regarding cross‐platform applicability.
Manyue Hu, Oliver Robinson, Christina M. Lill, Anna Matton, Raquel Puerta, Pilar Sanz, Merce Boada, Agustín Ruiz, Lefkos Middleton, for the Alzheimer's Disease Neuroimaging Initiative   +9 more
wiley   +1 more source

Combination value of cell index, CSF PCT, and CSF IL-6 for intracranial infection diagnosis after neurosurgery

Scientific Reports
This study evaluated the predictive value of cell index (CI), cerebrospinal fluid procalcitonin (CSF PCT), and cerebrospinal fluid interleukin-6 (CSF IL-6) for detecting intracranial infection after neurosurgery.
Caimu Wang, Yiping Zhou, Chao Zhong, Hui Shan, Ping Wang, Zisheng Ge, Yushi Fan, Xinyun Zhang, Kai Zhang, Yesong Wang, Wei Cui, Linlin Du, Qijiang Chen, Gensheng Zhang   +13 more
doaj   +1 more source

Neural activity induced by sensory stimulation can drive large-scale cerebrospinal fluid flow during wakefulness in humans

PLoS Biology, 2023
Cerebrospinal fluid (CSF) flow maintains healthy brain homeostasis, facilitating solute transport and the exchange of brain waste products. CSF flow is thus important for brain health, but the mechanisms that control its large-scale movement through the ...
Stephanie D. Williams, Beverly Setzer, Nina E. Fultz, Zenia Valdiviezo, Nicole Tacugue, Zachary Diamandis, Laura D. Lewis   +6 more
doaj  

Murine MPDZ-linked hydrocephalus is caused by hyperpermeability of the choroid plexus. [PDF]

, 2019
Though congenital hydrocephalus is heritable, it has been linked only to eight genes, one of which is MPDZ Humans and mice that carry a truncated version of MPDZ incur severe hydrocephalus resulting in acute morbidity and lethality.
Byrne, Matthew D., Horowitz, Arie, Ishikawa, Hiroshi, Kilker, Robert, Londin, Eric, Nichtova, Zuzana, Oakley, Laura, Pardeep-Kumar, Fnu, Pickup, Stephen, Saugier-Veber, Pascale, Schroten, Horst, Simonneau, Claire, Smeyne, Richard, Stefanescu, Ioana, Thakur, Mathew, Tripathi, Sushil, Willard, Belinda, Yang, Junning   +17 more
core   +2 more sources

The MMP‐9/TIMP‐1 Ratio and Concentrations of Osteopontin Are Elevated in Cerebrospinal Fluid of People With Multiple Sclerosis and Decrease After Autologous Hematopoietic Stem Cell Transplantation

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives To evaluate the utility of cerebrospinal fluid (CSF) biomarkers—matrix metalloproteinase‐9 (MMP‐9), tissue inhibitor of metalloproteinases‐1 (TIMP‐1), the MMP‐9/TIMP‐1 ratio, and osteopontin (OPN)—as indicators of blood–brain barrier (BBB) integrity and disease activity in people with relapsing–remitting multiple sclerosis (pwMS ...
Ivan Pavlovic, Ida Erngren, Kim Kultima, Anders Larsson, Malin Müller, Anna Wiberg, Joachim Burman   +6 more
wiley   +1 more source

Clinical utility of cerebrospinal fluid-derived circular RNAs in lung adenocarcinoma patients with brain metastases

Journal of Translational Medicine, 2022
Background Free circular RNAs(circRNAs) escaping from primary lesion of cancer to brain are strictly regulated by blood–brain barrier and therefore cerebrospinal fluid (CSF) circRNAs have potential advantage in exploring biomarkers and mechanism of brain
Zhen Wang, Ruoying Yu, Xiaoxi Chen, Hua Bao, Ran Cao, An-Na Li, Qiuxiang Ou, Hai-Yan Tu, Qing Zhou, Xue Wu, Zhi-Bo Lin, Yi-Long Wu   +11 more
doaj   +1 more source