Results 121 to 130 of about 244,039 (307)

Proteome-based plasma biomarkers for Alzheimer's disease [PDF]

, 2006
Alzheimer's disease is a common and devastating disease for which there is no readily available biomarker to aid diagnosis or to monitor disease progression.
A. Hye, Aliferis, Armstrong, Baird, Bauer, Bertram, Biroccio, Blennow, C. E. Shaw, C. Foy, C. Hooper, Cucullo, D'Andrea, DeKosky, Edwards, Esparza-Gordillo, F. Rijsdijk, Finehout, G. Hamilton, H. L. Byers, Hageman, Haines, Hampel, Hampel, Hampel, Irizarry, J. Campbell, J. Powell, Johnson, Klaver, Liu, Loeffler, Lopez, M. Causevic, M. Poppe, M. Thambisetty, M. Ward, Mattila, Mehta, Mullins, N. Archer, Nath, Newsome, P. Sham, R. G. Brown, Reisberg, Rodriguez de Cordoba, S. Banner, S. J. Tabrizi, S. Lovestone, S. Lynham, Scacchi, Strauss, Strohmeyer, Strohmeyer, Sunderland, Szafranski, Tam, Yang, Yocum, Zhang, Zipser, Zolotarjova   +62 more
core   +1 more source

Optimization of supervised self-organizing maps with genetic algorithms for classification electrophoretic profiles

Macedonian Journal of Chemistry and Chemical Engineering, 2014
Standard electrophoresis methods were used in the classification of analyzed proteins in cerebrospinal fluid from patients with multiple sclerosis. Disc electrophoresis was carried out for detection of oligoclonal IgG bands in cerebrospinal fluid on ...
Natalia Tomovska, Igor Kuzmanovski, Kiro Stojanoski   +2 more
doaj   +1 more source

Increased apolipoprotein E and decreased TNF‐α in the cerebrospinal fluid of nondemented APOE‐ε4 carriers

Neuropsychopharmacology Reports, 2020
Aim The ε4 allele of apolipoprotein E gene (APOE) is a well‐known risk factor of late‐onset Alzheimer's disease. However, little is known why this variant confers a risk for Alzheimer's disease.
Daimei Sasayama, Kotaro Hattori, Yuuki Yokota, Ryo Matsumura, Toshiya Teraishi, Sumiko Yoshida, Hiroshi Kunugi   +6 more
doaj   +1 more source

Elevated Cerebrospinal Fluid Proteins and Albumin Determine a Poor Prognosis for Spinal Amyotrophic Lateral Sclerosis. [PDF]

Int J Mol Sci, 2022
Assialioui A, Domínguez R, Ferrer I, Andrés-Benito P, Povedano M.   +4 more
europepmc   +1 more source

Cerebrospinal Fluid Analysis in Multiple Sclerosis Diagnosis: An Update [PDF]

, 2019
Multiple sclerosis (MS) is an immune-mediated demyelinating disease of the central nervous system (CNS) with brain neurodegeneration. MS patients present heterogeneous clinical manifestations in which both genetic and environmental factors are involved ...
Bruna Lo Sasso, Chiara Bellia, Giulia Bivona, Luisa Agnello, Marcello Ciaccio   +4 more
core   +1 more source

Proteins released from degenerating neurons are surrogate markers for acute brain damage

Neurobiology of Disease, 2004
The experimental and clinical study of degenerative brain disorders would benefit from new surrogate markers for brain damage. To identify novel candidate markers for acute brain injury, we report that rat cortical neurons release over 60 cytoskeletal ...
Robert Siman, Tracy K McIntosh, Kristie M Soltesz, Zhaoming Chen, Robert W Neumar, Victoria L Roberts   +5 more
doaj  

Evaluation of the Sensitivity and Reproducibility of Targeted Proteomic Analysis Using Data-Independent Acquisition for Serum and Cerebrospinal Fluid Proteins. [PDF]

J Proteome Res, 2021
Cho KC, Oh S, Wang Y, Rosenthal LS, Na CH, Zhang H.   +5 more
europepmc   +1 more source

Proteomics: in pursuit of effective traumatic brain injury therapeutics [PDF]

, 2015
Effective traumatic brain injury (TBI) therapeutics remain stubbornly elusive. Efforts in the field have been challenged by the heterogeneity of clinical TBI, with greater complexity among underlying molecular phenotypes than initially conceived.
Ahmed F, Andrew K Ottens, Bales JW, Begum G, Berger RP, Bonislawski DP, Bos R, Boulenguez P, Boutte AM, Brandner S, Brandner S, Campos-Martorell M, Cortes DF, Crawford F, Dachir S, Daoud H, Evans TM, Gackiere F, Gonzalez MI, Guingab-Cagmat JD, Gyorgy A, Gyorgy AB, Jaramillo ML, Jeter CB, Kabadi SV, Kabadi SV, Kahle KT, Kumar A, Levi S, Li BC, Liang J, Liang J, Lin WM, Loane DJ, Loov C, Lopez NE, Maier O, Manley GT, Maurer MH, Mehan ND, Mohseni S, Mondello S, Mondello S, Ottens AK, Ottens AK, Pavel N Lizhnyak, Prieto DA, Rau TF, Rosenfeld JV, Saatman KE, Schmid KE, Shen S, Shen Y, Siman R, Siman R, Sun C, Talley Watts L, Tsai YT, Wagner AK, Wu P, Xiong Y, Yu W, Zetterberg H, Zgavc T, Zhou XM   +64 more
core   +2 more sources

Online μSEC²-nRPLC-MS for Improved Sensitivity of Intact Protein Detection of IEF-Separated Nonhuman Primate Cerebrospinal Fluid Proteins. [PDF]

Anal Chem, 2021
Cline EN, Alvarez C, Duan J, Patrie SM.
europepmc   +1 more source

Serum protein halogenation and nitrosylation: trait of maintained overstimulation of blood phagocytes in sporadic Parkinson’s disease [PDF]

, 2013
Introduction: Halogenative and nitrosative stress are two types of oxidative stress that have been proposed as pathogenic mechanisms in Parkinson’s disease (PD). They can be caused by overstimulation of phagocytes. This hypothesis discusses serum protein
Fernández-Espejo, Emilio
core   +1 more source