Results 41 to 50 of about 9,336,854 (363)

Ceramide in cerebrovascular diseases

Frontiers in Cellular Neuroscience, 2023
Ceramide, a bioactive sphingolipid, serves as an important second messenger in cell signal transduction. Under stressful conditions, it can be generated from de novo synthesis, sphingomyelin hydrolysis, and/or the salvage pathway. The brain is rich in lipids, and abnormal lipid levels are associated with a variety of brain disorders.
Huiqi Yuan, Bin Zhu, Cao Li, Zhigang Zhao   +3 more
openaire   +3 more sources

Influence of COVID-19 on Cerebrovascular Disease and its Possible Mechanism

Neuropsychiatric Disease and Treatment, 2020
The global spread of COVID-19 has caused a substantial societal burden and become a major global public health issue. The COVID-19 elderly population with hypertension, diabetes, cardiovascular, and cerebrovascular diseases are at risk.
Hongyang Fan, Xiaojia Tang, Yuxia Song, Peipei Liu, Yingzhu Chen   +4 more
semanticscholar   +1 more source

Publisher Correction: Rapid endothelial cytoskeletal reorganization enables early blood–brain barrier disruption and long-term ischaemic reperfusion brain injury

Nature Communications, 2020
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Yejie Shi, Lili Zhang, Hongjian Pu, Leilei Mao, Xiaoming Hu, Xiaoyan Jiang, Na Xu, R. Anne Stetler, Feng Zhang, Xiangrong Liu, Rehana K. Leak, Richard F. Keep, Xunming Ji, Jun Chen   +13 more
doaj   +1 more source

PET in Cerebrovascular Disease [PDF]

PET Clinics, 2010
Investigation of the interplay between the cerebral circulation and brain cellular function is fundamental to understanding both the pathophysiology and treatment of stroke. Currently, PET is the only technique that provides accurate, quantitative in vivo regional measurements of both cerebral circulation and cellular metabolism in human subjects.
William J. Powers, Allyson R. Zazulia
openaire   +4 more sources

Allostatic load predicts racial disparities in intracerebral hemorrhage cognitive outcomes

Scientific Reports, 2022
A large portion of stroke disparities remains unexplained, even after adjusting for demographic, comorbidity, and health care access variables. There is a critical need to close this knowledge gap by investigating novel factors that may contribute to ...
Jennifer Harris, Amelia Boehme, Luisa Chan, Harmon Moats, Rachelle Dugue, Chigozirim Izeogu, Marykay A. Pavol, Imama A. Naqvi, Olajide Williams, Randolph S. Marshall   +9 more
doaj   +1 more source

A U-Net Deep Learning Framework for High Performance Vessel Segmentation in Patients With Cerebrovascular Disease

Frontiers in Neuroscience, 2019
Brain vessel status is a promising biomarker for better prevention and treatment in cerebrovascular disease. However, classic rule-based vessel segmentation algorithms need to be hand-crafted and are insufficiently validated.
Michelle Livne, J. Rieger, O. Aydin, A. Taha, E. M. Akay, Tabea Kossen, J. Sobesky, John D. Kelleher, Kristian Hildebrand, D. Frey, V. Madai   +10 more
semanticscholar   +1 more source

Safety and efficacy of the SeparGateTM balloon-guiding catheter in neurointerventional surgery: A prospective, multicenter, single-arm clinical trial

Journal of Interventional Medicine, 2022
Objective: To evaluate the safety and efficacy of the SeparGate™ balloon-guiding catheter (BGC) for blocking flow and delivering devices in neurointerventional surgery.
Huan Liu, Rufeng Jia, Yanyan He, Tengfei Zhou, Liangfu Zhu, Yonghong Ding, Juha Antero Hernesniemi, Tianxiao Li, Yingkun He   +8 more
doaj  

Immune and Clinical Features of CD96 Expression in Glioma by in silico Analysis

Frontiers in Bioengineering and Biotechnology, 2020
BackgroundImmune checkpoints target regulatory pathways in T cells that enhance antitumor immune responses and elicit durable clinical responses. As a novel immune checkpoint, CD96 is an attractive key target for cancer immunotherapy.
Qiang Zhang, Hua Zhong, Yinchun Fan, Qian Liu, Jiancheng Song, Shengtao Yao, Fang Cao   +6 more
doaj   +1 more source

Low expression or hypermethylation of PLK2 might predict favorable prognosis for patients with glioblastoma multiforme [PDF]

PeerJ, 2019
Background As the most aggressive brain tumor, patients with glioblastoma multiforme (GBM) have a poor prognosis. Our purpose was to explore prognostic value of Polo-like kinase 2 (PLK2) in GBM, a member of the PLKs family. Methods The expression profile
Xiangping Xia, Fang Cao, Xiaolu Yuan, Qiang Zhang, Wei Chen, Yunhu Yu, Hua Xiao, Chong Han, Shengtao Yao   +8 more
doaj   +2 more sources

Integration of Transcriptome Resequencing and Quantitative Proteomics Analyses of Collagenase VII-Induced Intracerebral Hemorrhage in Mice

Frontiers in Genetics, 2020
ObjectiveIntracerebral hemorrhage (ICH) is a subtype of stroke with high mortality and morbidity rates. Our aim was to comprehensively analyze transcriptome and proteome in an experimental ICH model.MethodsAll mice were divided into ICH model (n = 3) and
Fang Cao, Yu Guo, Qiang Zhang, Yinchun Fan, Qian Liu, Jiancheng Song, Hua Zhong, Shengtao Yao   +7 more
doaj   +1 more source