Results 61 to 70 of about 273,629 (339)

Liraglutide for idiopathic intracranial hypertension: a real‐world propensity score‐matched study

Annals of Clinical and Translational Neurology, EarlyView.
Abstract Objective Idiopathic intracranial hypertension (IIH) is a neurological disorder predominantly affecting young women with obesity, characterized by elevated intracranial pressure. While current treatments include weight loss counseling, medical therapies, and surgical interventions, their limitations necessitate exploring novel therapeutic ...
Ahmed Y. Azzam, Muhammed Amir Essibayi, Dhrumil Vaishnav, Mohammed A. Azab, Mahmoud M. Morsy, Osman Elamin, Adam Elswedy, Oday Atallah, Hana J. Abukhadijah, Adam A. Dmytriw, Amanda Baker, Deepak Khatri, Neil Haranhalli, David J. Altschul   +13 more
wiley   +1 more source

sLOX-1: A Molecule for Evaluating the Prognosis of Recurrent Ischemic Stroke

Neural Plasticity, 2021
Several clinical parameters and biomarkers have been proposed as prognostic markers for stroke. However, it has not been clarified whether the risk factors affecting the prognosis of patients with recurrent and first-ever stroke are similar.
Yangmin Zheng, Yuyou Huang, Lingzhi Li, Pingping Wang, Rongliang Wang, Zhen Tao, Junfen Fan, Ziping Han, Fangfang Li, Haiping Zhao, Fangfang Zhao, Feng Yan, Yumei Liu, Yumin Luo   +13 more
doaj   +1 more source

Shared features of endothelial dysfunction between sepsis and its preceding risk factors (aging and chronic disease) [PDF]

, 2018
Acute vascular endothelial dysfunction is a central event in the pathogenesis of sepsis,increasing vascular permeability, promoting activation of the coagulation cascade, tissue edema and compromising perfusion of vital organs. Aging and chronic diseases(hypertension,dyslipidaemia,diabetes mellitus,chronic kidney disease,cardiovascular disease ...
arxiv   +1 more source

The burden of intracranial atherosclerosis on cerebral small vessel disease: A community cohort study

Annals of Clinical and Translational Neurology, EarlyView.
Abstract Objective Exploring the prevalence and association between intracranial atherosclerosis (ICAS) and cerebral small vessel diseases (CSVD), this study delved beyond the current scope, utilising high‐resolution vessel wall MRI (HRVW‐MRI) to investigate how subtle changes in intracranial atherosclerotic features influence the various burdens of ...
Joseph Amihere Ackah, Heng Du, Wenjie Yang, Huixing Zeng, Jason Tsz Lok Chan, Michael Lung Cheung Lo, Xiangyan Chen   +6 more
wiley   +1 more source

Dual‐Phase C‐11 PiB PET Images for Detecting Tau Pathology in Cerebral Amyloid Angiopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Cerebral amyloid angiopathy (CAA) is a major cause of lobar intracerebral hemorrhage and cognitive dysfunction in the elderly, and frequently coexists with Alzheimer's disease and tau pathology. Dual‐phase 11C‐PiB PET detects amyloid deposition and cerebral perfusion changes and may have diagnostic value for identifying tau in CAA ...
Meng‐Ting Chiang, Chia‐Ju Liu, Bo‐Ching Lee, Ruoh‐Fang Yen, Hsin‐Hsi Tsai   +4 more
wiley   +1 more source

Association between endothelial activation and stress index and 30-day mortality risk in acute myocardial infarction patients: a study based on the medical information mart for intensive care-IV database

BMC Cardiovascular Disorders
Objective This study aimed to evaluate the association between the Endothelial Activation and Stress Index (EASIX) and 30-day mortality risk in acute myocardial infarction (AMI) patients.
Mingmin Sang, Xiaofeng Ma, Fangyi Zhu, Cunkui Zhu, Zuohua Ying   +4 more
doaj   +1 more source

Rapid endothelial cytoskeletal reorganization enables early blood–brain barrier disruption and long-term ischaemic reperfusion brain injury

Nature Communications, 2016
Matrix metalloproteinases (MMPs) released from infiltrating immune cells are a major contributor to blood-brain barrier (BBB) breakdown following stroke.
Yejie Shi, Lili Zhang, Hongjian Pu, Leilei Mao, Xiaoming Hu, Xiaoyan Jiang, Na Xu, R. Anne Stetler, Feng Zhang, Xiangrong Liu, Rehana K. Leak, Richard F. Keep, Xunming Ji, Jun Chen   +13 more
doaj   +1 more source

Impact of COVID-19 on Acute Stroke Presentation in a Designated COVID-19 Hospital

Frontiers in Neurology, 2021
Objectives: Thousands of designated COVID-19 hospitals have been set up in China to fight the ongoing COVID-19 pandemic. Anecdotal reports indicate a falling rate of acute stroke diagnoses in these hospitals during the COVID-19 period.
Qing Tan, Qing Tan, Qing-Jun Liu, Qing-Jun Liu, Wen-Hui Fan, Xiao-Yan Du, Xiao-Yan Du, Lin Wu, Lin Wu, Hong-Min Gong, Hong-Min Gong, Jing Wei, Jing Wei, Rui Zhao, Rui Zhao, Ming Lei, Ming Lei, Li-Bo Zhao, Li-Bo Zhao   +18 more
doaj   +1 more source

Genetics of Cerebrovascular Disease [PDF]

Stroke, 2004
Stroke is a complex disease, with both genetic and environmental factors having a role in its pathogenesis. A review of past studies shows some evidence of genetic influences in the development of stroke. This is supported by studies of cardiovascular disease, which indicate major genetic influences at several levels including the development of risk ...
openaire   +4 more sources

Development of a Disease Model for Predicting Postoperative Delirium Using Combined Blood Biomarkers

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Postoperative delirium, a common neurocognitive complication after surgery and anesthesia, requires early detection for potential intervention. Herein, we constructed a multidimensional postoperative delirium risk‐prediction model incorporating multiple demographic parameters and blood biomarkers to enhance prediction accuracy ...
Hengjun Wan, Huaju Tian, Cheng Wu, Yue Zhao, Daiying Zhang, Yujie Zheng, Yuan Li, Xiaoxia Duan   +7 more
wiley   +1 more source