Results 61 to 70 of about 9,336,854 (363)

Timing and Predictive Value of Clinical Conditions Preceding Multiple Sclerosis in the UK Biobank

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Multiple sclerosis (MS) patients often experience a higher incidence of clinical conditions before diagnosis, suggesting a prodromal phase. However, their predictive value and temporal trajectories remain underexplored. We investigated these aspects using the large UK Biobank's population‐based cohort, which provided clinical ...
Andrea Nova, Teresa Fazia, Giovanni Di Caprio, Davide Gentilini, Luisa Bernardinelli, Roberto Bergamaschi   +5 more
wiley   +1 more source

Effective Treatment With Afatinib of Lung Adenocarcinoma With Leptomeningeal Metastasis Harboring the Exon 18 p.G719A Mutation in the EGFR Gene Was Detected in Cerebrospinal Fluid: A Case Report

Frontiers in Oncology, 2020
Background: In patients with lung adenocarcinoma and leptomeningeal metastases, it remains unknown whether non-classical mutations in the epidermal growth factor receptor (EGFR) gene can be detected in the cerebrospinal fluid (CSF) and how it may be used
Chunhua Ma, Shuyuan Wang, Ning Mu, Jinduo Li, Mei Liu, Lin Li, Rong Jiang   +6 more
doaj   +1 more source

Associations of multiple chronic disease and depressive symptoms with incident stroke among Chinese middle-aged and elderly adults: a nationwide population-based cohort study

BMC Geriatrics, 2022
Background With the population aging, multiple chronic diseases, depressive symptoms, and stroke are increasingly common among middle-aged and elderly adults worldwide. This study aimed to explore the independent associations of multiple chronic diseases
Jingyang Hu, Xinyu Zheng, Guangduoji Shi, Lan Guo   +3 more
doaj   +1 more source

Epidemiology report: trends in sex-specific cerebrovascular disease mortality in Europe based on WHO mortality data

European Heart Journal, 2018
Aims There have been substantial declines in cerebrovascular disease mortality across much of Europe, mirroring trends in deaths from cardiovascular disease as a whole.
Rushabh Shah, Elizabeth Wilkins, Melanie Nichols, P. Kelly, Farah El-Sadi, F. L. Wright, N. Townsend, N. Townsend   +7 more
semanticscholar   +1 more source

Avoidable Hospitalizations in Persons With Rheumatoid Arthritis: A Population‐Based Study Using Administrative Data

Arthritis Care &Research, EarlyView.
Objective We estimated incidence rates of avoidable hospitalizations by persons with rheumatoid arthritis (RA) relative to the general population. Methods We identified individuals meeting a validated case definition for RA based on International Classification of Diseases, Ninth Revision, Clinical Modification (ICD‐9‐CM) and ICD‐10‐CA codes in years ...
Dani G. Contreras, Claire E. H. Barber, J. Antonio Aviña‐Zubieta, Hude Quan, Seungwon Lee, James A. King, Cheryl Barnabe   +6 more
wiley   +1 more source

Preparation of ROS‐Responsive Exosome Coating of Nitinol Material for Making the Neurointerventional Stent

Advanced Materials Interfaces, 2023
Nitinol (NiTi) alloy is an ideal material for preparing neurointerventional stents due to its excellent mechanical properties and biocompatibility. However, NiTi stents without surface‐specific functionalization cause a high rate of stent thrombosis and ...
Lin Duan, Yanyan He, Haigang Wu, Tianxiao Li, Jia Liang, Rufeng Jia, Dehua Guo, Taoyuan Lu, Chi Ma, Wenbo Liu, Yingkun He   +10 more
doaj   +1 more source

Time trends and predictors of gout remission over six years

Arthritis Care &Research, Accepted Article.
Objectives This study aims to describe the trends in remission rates over six years of follow‐up among people with gout taking urate‐lowering therapy (ULT), and to identify variables that predict remission. Methods A post hoc analysis was conducted using data from the Cardiovascular Safety of Febuxostat or Allopurinol in Patients with Gout (CARES ...
Adwoa Dansoa Tabi‐Amponsah, Sarah Stewart, Greg Gamble, Lisa K Stamp, William J Taylor, Nicola Dalbeth   +5 more
wiley   +1 more source

sLOX-1: A Molecule for Evaluating the Prognosis of Recurrent Ischemic Stroke

Neural Plasticity, 2021
Several clinical parameters and biomarkers have been proposed as prognostic markers for stroke. However, it has not been clarified whether the risk factors affecting the prognosis of patients with recurrent and first-ever stroke are similar.
Yangmin Zheng, Yuyou Huang, Lingzhi Li, Pingping Wang, Rongliang Wang, Zhen Tao, Junfen Fan, Ziping Han, Fangfang Li, Haiping Zhao, Fangfang Zhao, Feng Yan, Yumei Liu, Yumin Luo   +13 more
doaj   +1 more source

The Burden of Cerebrovascular Disease in the United States

Preventing Chronic Disease, 2019
Introduction Little is known about trends in the overall combined burden of fatal and nonfatal cerebrovascular disease events in the United States. Our objective was to describe the combined burden by age, sex, and region from 2006 through 2014.
X. Tong, Quanhe Yang, M. Ritchey, Mary G. George, S. Jackson, C. Gillespie, R. Merritt   +6 more
semanticscholar   +1 more source

Activation of SIRT1 Reduces Renal Tubular Epithelial Cells Fibrosis in Hypoxia Through SIRT1‐FoxO1‐FoxO3‐Autophagy Pathway

Advanced Biology, EarlyView.
Hypoxia promotes the epithelial‐mesenchymal transition (EMT) of renal tubular epithelial cells via the SIRT1‐FoxO1‐FoxO3‐autophagy pathway, thereby resulting in the fibrosis of renal tubular epithelial cells. Activation of SIRT1 or induction of autophagy inhibits this process, alleviating hypoxia‐induced fibrosis.
Guangyu Wang, Lijuan Zhang, Jiaorong Tan, Fei Li, Yishan Jin, Limei He, Xin Yang   +6 more
wiley   +1 more source