Results 41 to 50 of about 248,312 (241)

Will Memantine Exacerbate Seizures in People With Epilepsy? A Prospective Cohort Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate whether add‐on memantine would exacerbate seizures in people with epilepsy. Methods This was a prospective cohort study. People with epilepsy diagnosed with cognitive impairment were consecutively invited. Those who agreed were followed up for at least 24 weeks.
Peiyu Wang, Lu Lu, Hui Gao, Qi Zhang, Jing Xiao, Josemir W. Sander, Weixi Xiong, Dong Zhou   +7 more
wiley   +1 more source

Uric Acid Contributes to Obesity-Paradox of the Outcome of Ischemic Stroke

Frontiers in Neurology, 2019
Background: The mechanism of obesity paradox in stroke is not clear. This study aimed to investigate whether uric acid (UA) contributes to obesity-stroke outcome paradox.Material and Methods: The study cohort consisted of 1,984 IS patients recruited in ...
Hefei Tang, Hefei Tang, Hefei Tang, Hefei Tang, Jinglin Mo, Jinglin Mo, Jinglin Mo, Jinglin Mo, Zimo Chen, Zimo Chen, Zimo Chen, Zimo Chen, Jie Xu, Jie Xu, Jie Xu, Jie Xu, Anxin Wang, Anxin Wang, Anxin Wang, Anxin Wang, Liye Dai, Liye Dai, Liye Dai, Liye Dai, Aichun Cheng, Aichun Cheng, Aichun Cheng, Aichun Cheng, Yongjun Wang, Yongjun Wang, Yongjun Wang, Yongjun Wang   +31 more
doaj   +1 more source

Spinal Cord Infarction Versus Idiopathic Transverse Myelitis: Clinical, Radiological, and Functional Insights From a Retrospective Cohort Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Spinal cord infarction (SCI) is a rare but devastating myelopathy, characterized by a high disability rate and an unfavorable prognosis. It has often been underdiagnosed and misdiagnosed as idiopathic transverse myelitis (ITM). This study aimed to describe the clinical features, radiological biomarkers, treatments, and functional ...
Zeqiang Ji, Jianlong Zhang, Yiming Shi, Shiyu Shan, Yang Du, Guangshuo Li, Ying Jin, Yani Zhang, Chuanying Wang, Yijun Lin, Yuhao Guo, Decai Tian, Xingquan Zhao, Tian Song   +13 more
wiley   +1 more source

Financial Distress and Its Determinants in Rheumatoid Arthritis

Arthritis Care &Research, EarlyView.
Objective To quantify the degree of financial distress and identify its determinants in adults with rheumatoid arthritis (RA) given the frequent prolonged use of expensive disease‐modifying therapies. Methods We identified adults enrolled in the FORWARD databank with either RA or noninflammatory musculoskeletal disease (NIMSKD) completing the ...
Amber Brown Keebler, Yunju Im, Sofia Pedro, Ted R. Mikuls, Edward S. Peters, Kaleb Michaud   +5 more
wiley   +1 more source

Increased Levels of Serum IL-15 and TNF-β Indicate the Progression of Human Intracranial Aneurysm

Frontiers in Aging Neuroscience, 2022
ObjectiveExisting evidence suggests that chronic inflammation promotes the progression of human intracranial aneurysm (IA) and many cytokines have been detected to participate in the process of inflammation.
Shuzhe Yang, Shuzhe Yang, Shuzhe Yang, Shuzhe Yang, Qingyuan Liu, Qingyuan Liu, Qingyuan Liu, Qingyuan Liu, Junhua Yang, Junhua Yang, Junhua Yang, Junhua Yang, Jun Wu, Jun Wu, Jun Wu, Jun Wu, Shuo Wang, Shuo Wang, Shuo Wang, Shuo Wang   +19 more
doaj   +1 more source

Engineered ETS1‐Nanoconjugate Restores Immune Homeostasis through Dual Immune‐Vascular Modulation in Relapsing and Progressive Multiple Sclerosis

Advanced Healthcare Materials, EarlyView.
The biomimetic nanoplatform IMNP (ETS1 pDNA/PBAE@ITP‐MM) undergoes targeted disassembly at inflammatory vascular sites to release the ETS1 plasmid (pETS1). This release initiates a cascade of effects that inhibit pathogenic pathways and support immune homeostasis. (Abbreviations: EndMT, endothelial‐to‐mesenchymal transition; EC, endothelial cell; TC, T
Feng Zhang, Si‐Bo Yang, Yan Luo, Xiao‐Di Sun, Bo‐Hao Chang, Da‐Qiang Zhou, Jun‐Jie Jiang, Ya‐Nan Li, Jie‐Hong Wu, Hui‐Juan Jin, Hang Yang, Hang Hu, Yi‐Fan Zhou, Bo Hu   +13 more
wiley   +1 more source

Serum Occludin Level Combined With NIHSS Score Predicts Hemorrhage Transformation in Ischemic Stroke Patients With Reperfusion

Frontiers in Cellular Neuroscience, 2021
Hemorrhagic transformation (HT) is a severe complication following acute ischemic stroke, particularly with reperfusion interventions, leading to poor prognosis.
Shuhua Yuan, Weili Li, Chengbei Hou, Huining Kang, Qingfeng Ma, Xunming Ji, Zhifeng Qi, Ke Jian Liu   +7 more
doaj   +1 more source

Engineered Microfluidic Organoid Systems: New Paradigms for Menopause Mechanism Research and Personalized Medicine

Advanced Materials Technologies, EarlyView.
This review explores the integration of microfluidic technology with organoid systems as an innovative platform for studying menopausea complex multi‐organ condition. By enabling precise simulation of inter‐organ communication and hormone responses, microfluidic organoids offer a physiologically relevant model for investigating menopausal syndrome and ...
Qianyi Zhang, He Huang, Hongliang Dong, Qiang Ma, Hongyan Jin   +4 more
wiley   +1 more source

Upregulation of MicroRNA-128 in the Peripheral Blood of Acute Ischemic Stroke Patients is Correlated with Stroke Severity Partially through Inhibition of Neuronal Cell Cycle Reentry

Cell Transplantation, 2019
MiR-128, one of the most enriched miRNAs in the human brain, has been reported to protect MCAO mice via inhibiting P38α MAPK. Whether it is involved in pathogenesis in acute ischemic stroke patients remains to be determined.
Ping Liu, Ziping Han, Qingfeng Ma, Tao Liu, Rongliang Wang, Zhen Tao, Guangwen Li, Fangfang Li, Sijia Zhang, Lingzhi Li, Xuming Ji, Haiping Zhao, Yumin Luo   +12 more
doaj   +1 more source

A Tractography-Based Grading Scale of Brain Arteriovenous Malformations Close to the Corticospinal Tract to Predict Motor Outcome After Surgery

Frontiers in Neurology, 2019
Background: Surgical decision-making for brain arteriovenous malformations (AVMs) close to the corticospinal tract (CST) is always challenging. The purpose of this study was to develop a tractography-based grading scale to improve preoperative risk ...
Maogui Li, Maogui Li, Maogui Li, Maogui Li, Pengjun Jiang, Pengjun Jiang, Pengjun Jiang, Pengjun Jiang, Rui Guo, Rui Guo, Rui Guo, Rui Guo, Qingyuan Liu, Qingyuan Liu, Qingyuan Liu, Qingyuan Liu, Shuzhe Yang, Shuzhe Yang, Shuzhe Yang, Shuzhe Yang, Jun Wu, Jun Wu, Jun Wu, Jun Wu, Yong Cao, Yong Cao, Yong Cao, Yong Cao, Shuo Wang, Shuo Wang, Shuo Wang, Shuo Wang   +31 more
doaj   +1 more source