Results 61 to 70 of about 1,590,590 (272)

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem, Noa Bielopolski, Vijai Krishnan, Shane Wald‐Altman, Shelly I Shrian, Omer Bar‐Yosef, Livia Kapusta, Claire Shamber, Patricia L. Musolino, Miguel Weil   +9 more
wiley   +1 more source

Increased Levels of Serum IL-15 and TNF-β Indicate the Progression of Human Intracranial Aneurysm

Frontiers in Aging Neuroscience, 2022
ObjectiveExisting evidence suggests that chronic inflammation promotes the progression of human intracranial aneurysm (IA) and many cytokines have been detected to participate in the process of inflammation.
Shuzhe Yang, Shuzhe Yang, Shuzhe Yang, Shuzhe Yang, Qingyuan Liu, Qingyuan Liu, Qingyuan Liu, Qingyuan Liu, Junhua Yang, Junhua Yang, Junhua Yang, Junhua Yang, Jun Wu, Jun Wu, Jun Wu, Jun Wu, Shuo Wang, Shuo Wang, Shuo Wang, Shuo Wang   +19 more
doaj   +1 more source

Changes in Immune‐Inflammation Status and Prognosis in Pregnancy‐Related Cerebral Venous Thrombosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Distinguishing pathological changes from physiological adaptations in pregnancy‐related cerebral venous thrombosis (CVT) is clinically challenging. This study aimed to characterize coagulation, immune‐inflammation, and dehydration status in these patients and assess their prognostic value.
Xiaoming Zhang, Zilin Xu, Ran Duan, Chunxiao Lu, Da Zhou, Chen Zhou, Ran Meng, Xunming Ji   +7 more
wiley   +1 more source

Upregulation of MicroRNA-128 in the Peripheral Blood of Acute Ischemic Stroke Patients is Correlated with Stroke Severity Partially through Inhibition of Neuronal Cell Cycle Reentry

Cell Transplantation, 2019
MiR-128, one of the most enriched miRNAs in the human brain, has been reported to protect MCAO mice via inhibiting P38α MAPK. Whether it is involved in pathogenesis in acute ischemic stroke patients remains to be determined.
Ping Liu, Ziping Han, Qingfeng Ma, Tao Liu, Rongliang Wang, Zhen Tao, Guangwen Li, Fangfang Li, Sijia Zhang, Lingzhi Li, Xuming Ji, Haiping Zhao, Yumin Luo   +12 more
doaj   +1 more source

Prognostic Value of Elevated Cardiac Troponin I After Aneurysmal Subarachnoid Hemorrhage

Frontiers in Neurology, 2021
Object: Patients with aneurysmal subarachnoid hemorrhage (aSAH) have an increased incidence of cardiac events and short-term unfavorable neurological outcomes during the acute phase of bleeding.
Fa Lin, Fa Lin, Fa Lin, Fa Lin, Yu Chen, Yu Chen, Yu Chen, Yu Chen, Qiheng He, Qiheng He, Qiheng He, Qiheng He, Chaofan Zeng, Chaofan Zeng, Chaofan Zeng, Chaofan Zeng, Chaoqi Zhang, Chaoqi Zhang, Chaoqi Zhang, Chaoqi Zhang, Xiaolin Chen, Xiaolin Chen, Xiaolin Chen, Xiaolin Chen, Yuanli Zhao, Yuanli Zhao, Yuanli Zhao, Yuanli Zhao, Shuo Wang, Shuo Wang, Shuo Wang, Shuo Wang, Jizong Zhao, Jizong Zhao, Jizong Zhao, Jizong Zhao, Jizong Zhao   +36 more
doaj   +1 more source

Insomnias in patients with cerebrovascular disorders [PDF]

, 2018
The issue is devoted to modern approaches to the diagnosis and treatment of insomnia in patients with cerebrovascular pathology. A modern International classification of sleep disorders, a change in the classification and diagnostic criteria of insomnia ...
R. S. Saray, A. E. Barulin, O. V. Kurushina, E. A. Kurakova   +3 more
core   +1 more source

Diffuse MRI Edema Predicts Relapse in Cerebral Amyloid Angiopathy–Related Inflammation

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To identify MRI predictors of relapse and quantify relapse and mortality risk in cerebral amyloid angiopathy–related inflammation (CAA‐RI). A secondary objective was to assess the association between mycophenolate mofetil use and relapse risk. Methods We performed a retrospective cohort study of 36 patients with CAA‐RI treated at the
G. Abbas Kharal, Gowtham Yerneni, Kim J. Griffin, Nicolas Thompson, Ken Uchino, Irene Katzan, Dolora Wisco, Abeer Farrag, Jayashree Sundarajan, Andrew Russman, M. Shazam Hussain   +10 more
wiley   +1 more source

Predictive value of magnetic resonance angiography combined with serum ischemia-modified albumin for secondary cerebral infarction after transient ischemic attack

Thrombosis Journal
Objective This study investigated the diagnostic value of magnetic resonance angiography (MRA) combined with serum ischaemia-modifier albumin (IMA) testing in predicting secondary cerebral infarction (CI) following transient ischemic attack (TIA ...
Lige Liu, Qiuyue Yan, Jingyi Ai, Rudong Jiao, Meng Li   +4 more
doaj   +1 more source

A Tractography-Based Grading Scale of Brain Arteriovenous Malformations Close to the Corticospinal Tract to Predict Motor Outcome After Surgery

Frontiers in Neurology, 2019
Background: Surgical decision-making for brain arteriovenous malformations (AVMs) close to the corticospinal tract (CST) is always challenging. The purpose of this study was to develop a tractography-based grading scale to improve preoperative risk ...
Maogui Li, Maogui Li, Maogui Li, Maogui Li, Pengjun Jiang, Pengjun Jiang, Pengjun Jiang, Pengjun Jiang, Rui Guo, Rui Guo, Rui Guo, Rui Guo, Qingyuan Liu, Qingyuan Liu, Qingyuan Liu, Qingyuan Liu, Shuzhe Yang, Shuzhe Yang, Shuzhe Yang, Shuzhe Yang, Jun Wu, Jun Wu, Jun Wu, Jun Wu, Yong Cao, Yong Cao, Yong Cao, Yong Cao, Shuo Wang, Shuo Wang, Shuo Wang, Shuo Wang   +31 more
doaj   +1 more source

The Lupus Damage Index Revision Program: Results From the Item Generation and Reduction Phases

Arthritis Care &Research, EarlyView.
Objective A data‐driven and expert/patient consensus‐based project to develop a revised Systemic Lupus International Collaborating Clinics (SLICC)/American College of Rheumatology (ACR) Damage Index (SDI) is under way supported by SLICC, ACR, and the Lupus Foundation of America. Our objective is to report the item generation and reduction phase results
Burak Kundakci, Megan R. W. Barber, Ann E. Clarke, Sindhu R. Johnson, Anselm Mak, Hermine I. Brunner, Murat Inanc, Rosalind Ramsey‐Goldman, Guillermo Ruiz‐Irastorza, Ellen M. Ginzler, John G. Hanly, Alexandra Legge, Cynthia Aranow, Laurent Arnaud, Nathalie Costedoat‐Chalumeau, Dafna D. Gladman, Søren Jacobsen, Michelle Petri, Clovis A. Silva, Évelyne Vinet, Alexandre E. Voskuyl, SDI Revision Literature Review Groups, SDI Revision Delphi Panel, SDI Revision Item Reduction Committee, SDI Revision Clinical Domain Groups, Ian N. Bruce   +25 more
wiley   +1 more source