Results 71 to 80 of about 1,590,590 (272)

Cerebrovascular disorders in antiphospholipid syndrome

Анналы клинической и экспериментальной неврологии, 2017
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L. A. Kalashnikova
doaj   +1 more source

Advanced Materials for Biologics Delivery to Brain Tumors

Advanced Materials, EarlyView.
Material innovation is central to unlocking the therapeutic potential of biologics against many central nervous system diseases, including brain cancer. By engineering carriers with controlled transport, targeting, and release properties, advanced materials can overcome the blood–brain barrier and tumor microenvironment, improving the delivery of ...
Yuran Feng, Yuxue Cao, Maria Kavallaris, Taskeen Janjua, Amirali Popat   +4 more
wiley   +1 more source

Metabolic syndrome and cerebrovascular disorders

Анналы клинической и экспериментальной неврологии, 2017
A combination of a number of risk factors, known as metabolic syndrome (MS), leads to fast progression of vascular diseases and the development of severe complications.
M. M. Tanashyan, S. V. Orlov, R. B. Medvedev, O. V. Lagoda, N. G. Omelchenko, N. A. Glotova   +5 more
doaj   +1 more source

Effect of Low Diastolic Blood Pressure to Cardiovascular Risk in Patients With Ischemic Stroke or Transient Ischemic Attacks Under Different Systolic Blood Pressure Levels

Frontiers in Neurology, 2020
Background: In the context of recently updated strategies of pressure management, there is a paucity of evidence on the effect of diastolic blood pressure (DBP) level on adverse events among stroke patients.
Zimo Chen, Zimo Chen, Zimo Chen, Zimo Chen, Jinglin Mo, Jinglin Mo, Jinglin Mo, Jinglin Mo, Jie Xu, Jie Xu, Jie Xu, Jie Xu, Liye Dai, Liye Dai, Liye Dai, Liye Dai, Aichun Cheng, Aichun Cheng, Aichun Cheng, Aichun Cheng, Gulbahram Yalkun, Gulbahram Yalkun, Gulbahram Yalkun, Gulbahram Yalkun, Anxin Wang, Anxin Wang, Anxin Wang, Anxin Wang, Xia Meng, Xia Meng, Xia Meng, Xia Meng, Hao Li, Hao Li, Hao Li, Hao Li, Yongjun Wang, Yongjun Wang, Yongjun Wang, Yongjun Wang   +39 more
doaj   +1 more source

Esterified Cholesterol Conjugates Enable LNP‐Mediated mRNA Delivery to the Blood–Brain Barrier Following Intravenous Administration

Advanced Materials, EarlyView.
A cholesterol‐conjugated lipid library enabled the identification of a ligand‐free LNP platform for efficient mRNA delivery to brain endothelial cells via systemic administration. This platform achieves selective BBB targeting without disrupting barrier integrity, and enables modulation of neuroinflammation and vascular function without requiring trans‐
Zeru Tian, Xu Wang, Alexis Pacheco Benitez, Erick Guerrero, Yaou Duan, Jingwen Wei, Lukas Farbiak, Daniel J. Siegwart   +7 more
wiley   +1 more source

The combination model of serum occludin and clinical risk factors improved the efficacy for predicting hemorrhagic transformation in stroke patients with recanalization

Heliyon
Background: and Purpose: Hemorrhagic transformation (HT) is one of the severe complications in acute ischemic stroke, especially for the patients who undergo recanalization treatment.
Shuhua Yuan, Qingfeng Ma, Chengbei Hou, Weili Li, Ke Jian Liu, Xunming Ji, Zhifeng Qi   +6 more
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Seizure progression and inflammatory mediators promote pericytosis and pericyte-microglia clustering at the cerebrovasculature

Neurobiology of Disease, 2018
Background: Cerebrovascular dysfunction and inflammation occur in epilepsy. Here we asked whether pericytes, a pivotal cellular component of brain capillaries, undergo pathological modifications during experimental epileptogenesis and in human epilepsy ...
Wendy Klement, Rita Garbelli, Emma Zub, Laura Rossini, Laura Tassi, Benoit Girard, Marine Blaquiere, Federica Bertaso, Julie Perroy, Frederic de Bock, Nicola Marchi   +10 more
doaj   +1 more source

Modulation of miR‐23b Wnt/β‐catenin Axis Strengthens Endothelial Barrier Properties

Advanced Science, EarlyView.
Early blood‐brain barrier (BBB) disruption contributes to stroke and CNS disease pathology. miR‐23b was identified as a regulator of BBB integrity in brain endothelial cells. Inhibition of miR‐23b enhanced barrier‐associated properties, promoted repair‐related signaling, and reduced BBB leakage in experimental stroke models, supporting further ...
Victor Anthony Martinez, Rose E. Presby, Sara Nakanishi, Pallavi Gaur, Ugur Akcan, Johannes Daugaard Krog, Iben Daugaard Krog, Lipi Das, David S. Johnson, Danny Jamoul, Douglas Jury, Brian Lawson, Jacob Körbelin, Lewis M. Brown, Vilas Menon, Dritan Agalliu, Irene Munk Pedersen   +16 more
wiley   +1 more source

Astrocytic LMP2 Coordinates NF‐κB and TGF‐β1/Smad3 Signaling to Drive Neuroinflammation after Cerebral Ischemia/Reperfusion

Advanced Science, EarlyView.
ABSTRACT Astrocyte reactivity critically shapes neuroinflammatory outcomes after ischemic stroke, yet the upstream regulators governing astrocyte state transitions remain incompletely defined. Here, we identify the immunoproteasome subunit low molecular weight protein 2 (LMP2) as an important modulator of astrocyte functional remodeling following ...
Yanguang Mao, Rulan Ma, Zejing Lin, Huiying Zhao, Yuexian Liu, Yonghe Su, Xu Zhang, Xingyong Chen   +7 more
wiley   +1 more source

Uric Acid Contributes to Obesity-Paradox of the Outcome of Ischemic Stroke

Frontiers in Neurology, 2019
Background: The mechanism of obesity paradox in stroke is not clear. This study aimed to investigate whether uric acid (UA) contributes to obesity-stroke outcome paradox.Material and Methods: The study cohort consisted of 1,984 IS patients recruited in ...
Hefei Tang, Hefei Tang, Hefei Tang, Hefei Tang, Jinglin Mo, Jinglin Mo, Jinglin Mo, Jinglin Mo, Zimo Chen, Zimo Chen, Zimo Chen, Zimo Chen, Jie Xu, Jie Xu, Jie Xu, Jie Xu, Anxin Wang, Anxin Wang, Anxin Wang, Anxin Wang, Liye Dai, Liye Dai, Liye Dai, Liye Dai, Aichun Cheng, Aichun Cheng, Aichun Cheng, Aichun Cheng, Yongjun Wang, Yongjun Wang, Yongjun Wang, Yongjun Wang   +31 more
doaj   +1 more source