Results 71 to 80 of about 160,931 (269)

Macrophage HM13/SPP Enhances Foamy Macrophage Formation and Atherogenesis

Advanced Science, EarlyView.
Previous research suggests that AIP may prevent atherogenic foamy macrophage formation. This study reveals that AIP, via its chaperone interaction with AHR, inhibits p38‐c‐JUN‐mediated transactivation of HM13, which encodes the ERAD protease HM13/SPP. HM13/SPP promotes foamy macrophage formation in addition to atherogenesis and plaque foamy macrophage ...
Yu Cao, Qirong Xie, Qiang Zheng, Jingping Zhang, Mengyu Yao, Zhongyong Du, Lujun Zhang, Tianyang Hu, Yunli Zhao, Jianlin Du, Yongyong Li, Yuxing Feng, ND Melgiri, Xiaodong Zhao, Rongzhong Huang, Yang Sun   +15 more
wiley   +1 more source

Combinations of Tibetan tea and medicine food homology herbs: A new strategy for obesity prevention

Food Science &Nutrition, Volume 11, Issue 1, Page 504-515, January 2023., 2023
Combinations of Tibetan Tea and Medicine Food Homology Herbs, A new Strategy for Obesity Prevention. Abstract Obesity has become a significant global public health problem. Functional drinks have been an essential direction for obesity prevention research.
Ye Yuan, Bin Zhang, Jing‐liu He, Ting Wei, De‐jun Liu, Wen‐jun Yang, Cheng‐Yi Guo, Xu‐qiang Nie   +7 more
wiley   +1 more source

Redistribution of PDGFRβ cells and NG2DsRed pericytes at the cerebrovasculature after status epilepticus

Neurobiology of Disease, 2014
Purpose: The role of cerebrovascular dysfunction in seizure disorders is recognized. Blood–brain barrier (BBB) damage in epilepsy has been linked to endothelial and glial pathophysiological changes.
Sebastien Milesi, Badreddine Boussadia, Clement Plaud, Matthias Catteau, Marie-Claude Rousset, Frederic De Bock, Marie Schaeffer, Mireille Lerner-Natoli, Valerie Rigau, Nicola Marchi   +9 more
doaj  

Integrative Multi‐Omics and Routine Blood Analysis Using Deep Learning: Cost‐Effective Early Prediction of Chronic Disease Risks

Advanced Science, EarlyView.
Omicsformer, a deep learning model, integrates multi‐omics and routine blood data to accurately predict risks for nine chronic diseases, including cancer and cardiovascular conditions. Validated using large scale clinical data, it reveals early risk trajectories, advancing personalized medicine and offering a cost‐effective, community‐based solution ...
Zhibin Dong, Pei Li, Yi Jiang, Zhihan Wang, Shihui Fu, Hebin Che, Meng Liu, Xiaojing Zhao, Chunlei Liu, Chenghui Zhao, Qin Zhong, Chongyou Rao, Siwei Wang, Suyuan Liu, Dayu Hu, Dongjin Wang, Juntao Gao, Kai Guo, Xinwang Liu, En Zhu, Kunlun He   +20 more
wiley   +1 more source

Impact of prevention in primary care on costs in primary and secondary care for people with serious mental illness

Health Economics, Volume 32, Issue 2, Page 343-355, February 2023., 2023
Abstract A largely unexplored part of the financial incentive for physicians to participate in preventive care is the degree to which they are the residual claimant from any resulting cost savings. We examine the impact of two preventive activities for people with serious mental illness (care plans and annual reviews of physical health) by English ...
Jemimah Ride, Panos Kasteridis, Nils Gutacker, Hugh Gravelle, Nigel Rice, Anne Mason, Maria Goddard, Tim Doran, Rowena Jacobs   +8 more
wiley   +1 more source

Multi-level SVM Based CAD Tool for Classifying Structural MRIs [PDF]

arXiv, 2017
The revolutionary developments in the field of supervised machine learning have paved way to the development of CAD tools for assisting doctors in diagnosis. Recently, the former has been employed in the prediction of neurological disorders such as Alzheimer's disease.
arxiv  

CXCL13 Damages Blood Spinal Cord Barrier by Promoting RNF6/Sqstm1‐Ubiquitination Induced Autophagy in Experimental Allergic Encephalomyelitis

Advanced Science, EarlyView.
In multiple sclerosis, the disruption of the blood‐spinal cord barrier (BSCB) induced by CXCL13 facilitates the infiltration of inflammatory cells into the central nervous system, resulting in demyelination and neuronal injury. Mechanistically, the deleterious impact of CXCL13 on the BSCB is associated with a reduction in tight junction protein ...
Jingjing Han, Rui Hong, Cong Cao, Wanhua Feng, Wei Zhuang, Gui Wang, Jingchao Tang, Ya Yang, Chu Zhang, Aihua Zhou, Xuebin Qu   +10 more
wiley   +1 more source

Risk Profile of Ischemic Stroke Caused by Small-Artery Occlusion vs. Deep Intracerebral Hemorrhage

Frontiers in Neurology, 2019
Background: Small-artery occlusion (SAO) subtype accounts for a quarter of the cases of ischemic stroke and is mainly caused by pathological changes in cerebral small vessels, which also involve in deep intracerebral hemorrhage (dICH).
Zimo Chen, Zimo Chen, Zimo Chen, Zimo Chen, Jinglin Mo, Jinglin Mo, Jinglin Mo, Jinglin Mo, Jie Xu, Jie Xu, Jie Xu, Jie Xu, Haiqiang Qin, Haiqiang Qin, Haiqiang Qin, Haiqiang Qin, Huaguang Zheng, Huaguang Zheng, Huaguang Zheng, Huaguang Zheng, Yuesong Pan, Yuesong Pan, Yuesong Pan, Yuesong Pan, Xia Meng, Xia Meng, Xia Meng, Xia Meng, Jing Jing, Jing Jing, Jing Jing, Jing Jing, Xianglong Xiang, Xianglong Xiang, Xianglong Xiang, Yongjun Wang, Yongjun Wang, Yongjun Wang, Yongjun Wang   +38 more
doaj   +1 more source

The Case of a 67‐Year‐Old Man With Memory Difficulties and Altered Sleep

Annals of Clinical and Translational Neurology, EarlyView.
Wesley Peng, Borna Bonakdarpour
wiley   +1 more source

Homocysteine Promotes the Pathogenesis of Atherosclerosis through the Circ‐PIAS1‐5/miR‐219a‐2‐3p/TEAD1 Axis

Advanced Science, EarlyView.
A model is schematically represented for the major molecular mechanisms by which homocysteine (Hcy) accelerates the nuclear export of circ‐PIAS1‐5, which regulates atherosclerosis by acting as a competing endogenous RNA for miR‐219a‐2‐3p. Hcy enrichment of circ‐PIAS1‐5 leads to YTHDC1 binding to circ‐PIAS1‐5 and promotes its intracellular localization ...
Shengchao Ma, Fei Ma, Ning Ding, Lin Xie, Anning Yang, Jiangyong Shen, Yun jiao, Kai Wu, YueE Chai, Zhigang Bai, Jiantuan Xiong, Nan Li, Huiping Zhang, Yideng Jiang   +13 more
wiley   +1 more source