Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
An examination of communication mechanism of ancestral hall sacrifice rituals in rural southern China. [PDF]
Zhang Y, Jiang Y.
europepmc +1 more source
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Matcha as a Source of Bioactive Compounds: A Review of Health-Promoting Properties and Potential Applications. [PDF]
Sławińska P, Raczkowska E.
europepmc +1 more source
Finding Common Ground: Indigenous Research Methods Facilitate Scientific Knowledge Sharing in Cross-Cultural Wildlife Research. [PDF]
Campbell B +6 more
europepmc +1 more source
Factors influencing infant feeding practices of Indian immigrant mothers in Australia-a qualitative exploratory study. [PDF]
Tulpule C +3 more
europepmc +1 more source
Ethnogeographic Distribution of Nigerian Fermented Foods and the Prospects for Bioeconomy Improvements. [PDF]
Olanbiwoninu AA +4 more
europepmc +1 more source
Indigenous and local knowledge inclusion in forest fauna research: A systematic review in the tropics. [PDF]
Hernández-Vélez CA +2 more
europepmc +1 more source
"Guide them to have a future orientation": qualitative findings in developing a reinforcement-based intervention to address alcohol use with American Indian emerging adults. [PDF]
Hirchak KA +6 more
europepmc +1 more source

