Results 191 to 200 of about 1,067,361 (326)

Rethinking global health training: making the links between theory and practice. [PDF]

open access: yesCan Med Educ J
Fisher LA   +4 more
europepmc   +1 more source

Lipid Droplet‐Organized MDM2‐Mediated P53 Degradation: A Metabolic Switch Governing Diet‐Driven Tumor Progression

open access: yesAdvanced Science, EarlyView.
Tumor‐associated TP53 inactivation correlates with lipid droplet (LD) accumulation. High‐fat diets drive Cyb5r3‐Myh9‐mediated p53 enrichment on LD surfaces, accelerating its degradation while upregulating LD‐promoting factor CD36 expression to establish a feed‐forward loop. LD suppression or dietary intervention restores p53 and inhibits tumorigenesis,
Haiyang Liu   +20 more
wiley   +1 more source

Sustainable Development of High‐performance Poly(ester‐imine) Biobased Thermosets

open access: yesAdvanced Science, EarlyView.
Schiff‐based epoxy monomers derived from renewable natural resources are used to design robust structures by cross–linking with bio‐anhydrides. The resulting eco‐friendly, high‐performance thermosets feature two cleavable bonds, offering versatility for various applications.
Roxana Dinu   +3 more
wiley   +1 more source

Targeted Penetrating Motif Engineering of BH3 Mimetic: Harnessing Non‐Canonical Amino Acids for Coinhibition of MCL‐1 and BCL‐xL in Acute Myeloid Leukemia

open access: yesAdvanced Science, EarlyView.
A structure‐guided peptide derived from a non‐canonical amino acid library simultaneously targets MCL‐1 and BCL‐xL to overcome apoptotic resistance in acute myeloid leukemia. Fused with a CXCR4‐binding motif, the engineered peptide exhibits selective intracellular delivery and potent in vivo efficacy, offering a promising therapeutic strategy against ...
Zhe Wang   +11 more
wiley   +1 more source

Home - About - Disclaimer - Privacy