Results 181 to 190 of about 1,095,514 (301)

COVID-19 as cause of death: a bridge coding study. [PDF]

GMS Infect Dis
Harteloh P.
europepmc   +1 more source

Delivery of Pleckstrin‐Homology Domains Suppresses PI3K/Akt Signaling and Breast Cancer Metastasis

Advanced Science, EarlyView.
Current therapies curb tumor growth but not metastasis. Obscurin, a giant metastasis suppressor lost in breast cancer, restrains PI3K/Akt signaling but is impractical to restore. We deploy a mini‐obscurin, comprising the obscurin‐PH‐domain, which sequesters PI3K‐p85, potently suppressing invasion and metastasis.
Matthew Eason, Anindya Sen, Suhan Cho, Se Jong Lee, Keyata Thompson, Md Musavvir Mahmud, Poornima Dubey, Talia Guardia, Anthony Kim, Stuart Martin, Nathan Wright, Konstantinos Konstantopoulos, Aikaterini Kontrogianni‐Konstantopoulos   +12 more
wiley   +1 more source

Behaviour change solutions driven by cognitive insights for improving TB health care seeking among vulnerable population: an exploratory multi-state qualitative study in India. [PDF]

BMC Public Health
Sinha A, Ponnuchamy L, Kowlgi A, Kar A, Nagrajan K, Potty RS, Majumder S, Begum R, Munjattu JF, Majhi G, Rao A, Swamickan R, Shah A, Kumarasamy K.   +13 more
europepmc   +1 more source

Mitochondria and Neuromast Tagging With Fluorescent Gallium‐Triapine Analogues: In Cellulo MP FLIM and Zebrafish Live Imaging

Advanced Science, EarlyView.
Fluorescent BODIPY‐conjugated thiosemicarbazone ligands and their Ga(III), In(III), and Fe(III) complexes, inspired by Triapine, are developed as theranostic agents. Multiphoton FLIM and confocal microscopy in cancer cells and zebrafish reveal real‐time uptake, mitochondrial localisation, and whilst spectroscopic assays indicated preserved complex ...
Megan J. Green, Michael W. Jones, Merissa Saleem, Haobo Ge, Melita Tvardauskaite, Julia Dudzic, Fernando Cortezon‐Tamarit, Rory L. Arrowsmith, Charareh Pourzand, Gabriele Kociock‐Kohn, Nicholas H. Rees, Jonathan R. Dilworth, Stephen Faulkner, Stanley W. Botchway, David Gurevich, Sofia I. Pascu   +15 more
wiley   +1 more source

Misclassification of Homeless Status at Death, Multnomah County, Oregon, 2023. [PDF]

Public Health Rep
Walters J, Mosites E, Hall E, Snowden JM.   +3 more
europepmc   +1 more source

Inhibition of SIRT7 Overcomes Radioresistance in Pancreatic Neuroendocrine Tumors by Reactivating MEN1 Expression

Advanced Science, EarlyView.
Pancreatic neuroendocrine tumors frequently silence MEN1 through epigenetic mechanisms. Here, SIRT7 recruits DNMT1 to the MEN1 promoter, drives hypermethylation, and enhances DNA repair. Inhibiting SIRT7 restores MEN1, reduces MRN complex abundance, impairs double‐strand break repair, and sensitizes PanNET models to radiation, supporting SIRT7 as a ...
Jianyun Jiang, Yan Wang, Yi Qin, Luohai Chen, Xiaowu Xu, Guixiong Fan, Desheng Jing, Miaoyan Wei, Xianjun Yu, Junfeng Xu, Shunrong Ji, Jie Chen   +11 more
wiley   +1 more source

Multi‐Organelle Stress‐Induced Paraptosis by a ROS‐Amplifying Nanocatalyst for Enhanced Cancer Immunotherapy

Advanced Science, EarlyView.
The engineered TF‐Fe@LC nanoplatform programs paraptotic death via multipath ROS amplification that disrupts redox homeostasis, provoking mitochondrial dysfunction, autophagic blockade, and ER stress. This caspase‐independent process elicits robust immunogenic cell death, combining with αPD‐L1 to activate systemic CD8+ T‐cell immunity and suppress ...
Zhe Yu, Haozhe Ren, Hua Li, Jinghan Zhao, Miaomiao Cao, Tian Tang, Youbei Qiao, Liting Chen, Tiehong Yang, Hong Wu   +9 more
wiley   +1 more source

Midwives practices and mothers' experiences during intrapartum midwifery care: a qualitative study. [PDF]

BMC Pregnancy Childbirth
Katushabe E, Musa-Maliki A, Steen M.
europepmc   +1 more source

Axial F–Bi–Ov Electron Pump Drives Continuous Reconfiguration of Bi Sites for Efficient Photocatalytic N2 Reduction

Advanced Science, EarlyView.
Axial Fluorine and Light‐Induced Oxygen Vacancies Synergize as an Electron Pump to Lower N2 Activation Energy and Enable Sustained NH3 Synthesis on FBWO. ABSTRACT The electronic structure precision of single‐atom catalysts (SACs) represents a decisive factor limiting advancements in photocatalytic nitrogen reduction (NRR) efficiency.
Xiao Ge, Xinyi Wu, Hao‐tong Li, Xinya Liu, Jie‐jie Chen, Yuan Min, Xiaozhi Wang   +6 more
wiley   +1 more source

Characteristics of the Washington Group Short Set in Assessing Functional Difficulty Among People With Physical Disability Certificates of Vision, Hearing, and Lower-Limb Impairments in Japan. [PDF]

Cureus
Saito T, Imahashi K.
europepmc   +1 more source