Results 161 to 170 of about 150,205 (266)

Machine Learning‐Enhanced Ultrasensitive Immuno‐CRISPR Array Facilitates Early Diagnosis of Alzheimer's Disease by Detecting Multiple Plasma Biomarkers

open access: yesAdvanced Science, EarlyView.
This work presents a CRISPR‐based, ultrasensitive multiplex protein detection array capable of simultaneously analyzing six plasma biomarkers associated with Alzheimer's disease (AD). By integrating antibody‐mediated signal transduction, recombinase polymerase amplification, and spatially encoded CRISPR‐Cas12a, the system achieves detection sensitivity
Liding Zhang   +9 more
wiley   +1 more source

Down Syndrome Births Among Live Births from the CDC Wonder Database. [PDF]

open access: yesChildren (Basel)
Santoro SL   +4 more
europepmc   +1 more source

RNF138‐Mediated Ubiquitination and Degradation of NS5 Restricts Tick‐Borne Encephalitis Virus Infection

open access: yesAdvanced Science, EarlyView.
Host‐specific compatibility between RNF138‐like proteins and flavivirus NS5 determines NS5 stability. Mammalian RNF138 but not arthropod homologs recognizes and induces conserved NS5/RdRp K48‐linked ubiquitination and proteasomal degradation, thereby restricting viral replication. Ectopic RNF138 in mice attenuates TBEV‐induced pathogenesis. (Created in
Jialiang Sun   +6 more
wiley   +1 more source

Change in self-reported tobacco cessation support practices among HIV providers in Kisumu, Kenya: a pre-post evaluation of a web-based training programme nested within the IN-ToUCH cluster randomised trial. [PDF]

open access: yesBMJ Public Health
Olando YA   +16 more
europepmc   +1 more source

Sulfonated Bathocuproine Derivatives as Chemically Bonded Buried‐Interface Engineers for n–i–p Perovskite Solar Cells

open access: yesAdvanced Science, EarlyView.
A BCP‐derived buried‐interface strategy establishes Na‐BCS as a chemically bonded molecular bridge. By combining sulfonate anchoring to SnO2 with preserved BCP–Pb2+ coordination, Na‐BCS simultaneously passivates oxide‐ and perovskite‐side defects, suppresses non‐radiative recombination, and delivers a surface recombination velocity of 8.6 cm s−1, a ...
Dong Hyun Kim   +9 more
wiley   +1 more source

Surfaceome Reprogramming of Stemsomes Promotes Lung Cancer Targeting via Potentiated Receptor–Ligand Interactions

open access: yesAdvanced Science, EarlyView.
This study presents a surfaceome‐reprogramming strategy for mutation‐independent lung cancer therapy by repurposing dexamethasone to prime mesenchymal stem cell‐derived nanovesicles. The engineered vesicles leverage multi‐valent interactions mediated by upregulated adhesion proteins, EPHA2, and NOTCH3.
Geunhye Kim   +8 more
wiley   +1 more source

Pathology Following Stillbirth: Differences by Insurance Status and Educational Attainment. [PDF]

open access: yesPaediatr Perinat Epidemiol
Diamond E   +5 more
europepmc   +1 more source

Unconstrained Coordination of Pt Single Atoms on Distorted g‐C3N4 Enables Electronic Flexibility and Enhanced Microplastics Photoreforming

open access: yesAdvanced Science, EarlyView.
This study reveals Pt single atoms anchored on distorted graphitic carbon nitride, exhibiting flexible coordination and enhanced interfacial charge transfer. Combined spectroscopy and DFT reveal asymmetric Pt─N environments that promote photoreforming of microplastics into hydrogen, demonstrating a solar‐driven pathway for plastic upcycling with ...
Ting‐Han Lin   +9 more
wiley   +1 more source

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