Results 41 to 50 of about 150,205 (266)

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

КОНКУРСНО-ОЛИМПИАДНАЯ ДЕЯТЕЛЬНОСТЬ ОБУЧАЮЩИХСЯ ВУЗА

Научно-педагогическое обозрение, 2021
Освещена конкурсно-олимпиадная деятельность как один из инструментов образовательного процесса. Дан анализ участия студентов филиала Дальневосточного федерального университета в г. Находке в конкурсах и олимпиадах за период 2019 г.
Куликова Виктория Викторовна, Ковалёва Елена Анатольевна   +1 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Approach to and practical challenges in certification in Psychiatry

Indian Journal of Psychiatry, 2019
Psychiatrists and mental health professionals (MHPs) are often requested to provide a certificate in connection with admission, treatment, fitness, competence, administration, legal proceedings, or welfare measures and benefits for persons with mental ...
Furkhan Ali, Guru S. Gowda, Mahesh Gowda
doaj   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Protocol for quantifying miRNA trafficking across the endosomal membrane

FEBS Open Bio, EarlyView.
An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh, Kamalika Mukherjee, Suvendra N. Bhattacharyya   +2 more
wiley   +1 more source

Utility of advanced training skills among GPs: a systematic review

Rural and Remote Health
Introduction: Advanced Skills Training (AST) is designed to provide GPs with an opportunity to enhance their clinical practice in a narrower speciality.
Hannah Mason, Abdul-Aziz Seidu , Francis Albert, Emma Anderson, Faith Alele, Lawrie McArthur, Aaron Hollins, Paula Heggarty, Tarun Sen Gupta, Richard Hays, Bunmi Malau-Aduli   +10 more
doaj   +1 more source

Clinical implications for the optometrist when assessing post LASIK patients

African Vision and Eye Health, 2013
Laser assisted in situ keratomileusis (LASIK) has dominated the field of refractive surgery in the new millennium with many patients opting for it as an alternative to spectacles or contact lenses.
R. Hansraj
doaj   +1 more source

Self‐Regulated Learning Meets AI: Reinterpreting Self‐Regulation, Co‐Regulation, and Socially Shared Regulation in Human–AI Interaction

New Directions for Adult and Continuing Education, EarlyView.
ABSTRACT Advancing artificial intelligence (AI) has transformed learning and work, yet higher education and professional development programs have not systematically equipped learners for AI‐prevalent environments. This lack of preparation creates uncertainty regarding control, responsibility, trust, and accountability.
Moon‐Heum Cho, Jerusalem Merkebu
wiley   +1 more source

On the issue of the blockchain technology perspectives. The more things change, the more they stay the same

Безопасность информационных технологий, 2018
Blockchain technologies (BC) are immutable distributed systems of digital ledgers (i.e., without central repository) and, as rule, without central authority. Currently, there is a lot of excitement around the use of BC technology, although the technology
Vladimir I. Budzko, Dmitry A. Melnikov
doaj   +1 more source