Results 61 to 70 of about 1,134,207 (301)

NOTCH2NLC Repeat Expansions in Parkinsonian Disorders: Clinical and Neuroimaging Characteristics

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neuronal intranuclear inclusion disease (NIID) is a neurodegenerative disorder caused by NOTCH2NLC GGC repeat expansions, with heterogeneous clinical manifestations, including parkinsonism. Recent studies have identified NOTCH2NLC repeat expansions in patients with Parkinson's disease (PD) and atypical parkinsonism (aPM), suggesting ...
Han‐Lin Chiang, Kang‐Yang Jih, Cheng‐Tsung Hsiao, Fu‐Pang Chang, Justus Chunyu Chen, Yi‐Chu Liao, Yih‐Ru Wu, Yi‐Chung Lee   +7 more
wiley   +1 more source

On the issue of the blockchain technology perspectives. The more things change, the more they stay the same

Безопасность информационных технологий, 2018
Blockchain technologies (BC) are immutable distributed systems of digital ledgers (i.e., without central repository) and, as rule, without central authority. Currently, there is a lot of excitement around the use of BC technology, although the technology
Vladimir I. Budzko, Dmitry A. Melnikov
doaj   +1 more source

Central Dysmyelination in SSADH‐Deficient Humans and Mice

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Succinic semialdehyde dehydrogenase deficiency (SSADHD) is an inherited metabolic disorder characterized by an accumulation of γ‐aminobutyric (GABA). In addition to its synaptic role as an inhibitory neurotransmitter, GABA also plays an important role in myelination.
Itay Tokatly Latzer, Henry H. C. Lee, Edward Yang, Cesar Alves, Mariarita Bertoldi, Caitlyn Fung, Spencer V. Steele, Eren Kule, Zijie Jin, Alexander Rotenberg, Jean‐Baptiste Roullet, Phillip L. Pearl   +11 more
wiley   +1 more source

A Survey on Life-Cycle-Oriented Certificate Management in Industrial Networking Environments

Journal of Sensor and Actuator Networks
Driven by the Industry 4.0 paradigm and the resulting demand for connectivity in industrial networking, there is a convergence of formerly isolated operational technology and information technology networks.
Julian Göppert, Andreas Walz, Axel Sikora   +2 more
doaj   +1 more source

Certificates as a Way to Regulate Functioning of Tourist Entities on the Spa & Wellness Services Market

Ekonomiczne Problemy Turystyki, 2016
Goal of the paper is to describe certificates of hotel objects operating in the market of SPA & wellness services as a way of its functioning. This paper is based on analysis of literature, manyyears observances of the authors as well as results of ...
Małgorzata Januszewska, Agnieszka Mroczek-Czetwertyńska, Elżbieta Nawrocka   +2 more
doaj   +1 more source

Alumni of the First Ten Years of Nippon Foundation/GEBCO Postgraduate Certificate in Ocean Bathymetry Training Program [PDF]

, 2014
The Nippon Foundation/GEBCO Training Programme is a twelve-month course leading to a Postgraduate Certificate in Ocean Bathymetry (PCOB). It is held at the University of New Hampshire, USA and is helping to develop a new generation of seafloor mappers ...
Wigley, Rochelle A.
core   +1 more source

ICU‐EEG Pattern Detection by a Convolutional Neural Network

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Patients in the intensive care unit (ICU) often require continuous EEG (cEEG) monitoring due to the high risk of seizures and rhythmic and periodic patterns (RPPs). However, interpreting cEEG in real time is resource‐intensive and heavily relies on specialized expertise, which is not always available.
Giulio Degano, Hervé Quintard, Andreas Kleinschmidt, Nikita Francini, Oana E. Sarbu, Pia De Stefano   +5 more
wiley   +1 more source

Long‐Term Evaluation of Givinostat in Duchenne Muscular Dystrophy, and Natural History Comparisons

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives This ongoing, open‐label extension study is evaluating the long‐term safety, tolerability, and efficacy of givinostat, a Class I and II histone deacetylase inhibitor, in patients with Duchenne muscular dystrophy (DMD). Methods The recruited patients completed one of two prior clinical studies (one Phase 2 and one Phase 3 [EPIDYS ...
Craig M. McDonald, Michela Guglieri, Dragana Vučinić, Gyula Acsadi, John F. Brandsema, Claudio Bruno, Erika L. Finanger, Amy Harper, Mercedes Lopez Lobato, Riccardo Masson, Nuria Muelas, Francina Munell, Yoram Nevo, Yann Péréon, Han Phan, Valeria A. Sansone, Mariacristina Scoto, Tracey Willis, Richard S. Finkel, Krista Vandenborne, Sara Cazzaniga, Silvia Montrasio, Federica Alessi, Paolo Bettica, Eugenio Mercuri, for the Givinostat Study 51 Investigators, the Cooperative International Neuromuscular Research Group (CINRG) Duchenne Natural History Study (DNHS) Investigators, the ImagingDMD Investigators, Enrico Bertini, Giacomo Pietro Comi, Eugenio Maria Mercuri, Giuseppe Vita, Sonia Messina, Claudio Bruno, Riccardo Masson, Valeria Sansone, Nathalie Goemans, Liesbeth De Waele, Laurent Servais, Teresa Gidaro, Odile Boespflug‐Tanguy, Yann Péréon, Jessika Johannsen, Astrid Blaschek, Ulrike Schara‐Schmidt, Erik Niks, Imelda de Groot, Saskia Houwen‐van Opstal, Andres Nascimento, Juan Jesus Vilchez, Nuria Muelas, Francina Munell, Marcos Madruga Garrido, Mercedes Lopez Lobato, Michaela Guglieri, Tracey Willis, Stefan Spinty, Daniel Hawcutt, Mariacristina Scoto, Jean K. Mah, Laura McAdam, Kathryn Selby, Katherine Mathews, Craig McDonald, Craig Zaidman, Barry Byrne, John Brandsema, Gyula Acsadi, Chamindra Laverty, Amy Harper, Erika Finanger, Han Phan, Yoram Nevo, Vedrana Milic Rasic, Dragana Vucinic   +74 more
wiley   +1 more source

ASSISTING OF NUANSA GEMBIRA COFFEE PRODUCTS TOWARDS HALAL CERTIFICATIONS WITH THE SI-HALAL APPLICATION IN DELES VILLAGE, BATANG DISTRICT, CENTRAL JAVA

Jurnal Layanan Masyarakat (Journal of Public Services)
A halal certificate is a legal requirement that must be fulfilled for every Micro, Small, and Medium Enterprise. Kopi Nuansa Gembira is a pure, original ground coffee business without any mixtures which still does not have halal certification.
Lely Afiati, Liesta Verawati, Muhamad Anwar   +2 more
doaj   +1 more source

The Changing Landscape of Graduate Teaching Certificate Programs in Canada

Canadian Journal for the Scholarship of Teaching and Learning, 2020
In a 2014 paper, Kenny, Watson, and Watton analyzed 13 Canadian universities offering graduate teaching certificate programs. This research used the Kenny et al.
Stephanie Verkoeyen, Erin Allard
doaj   +1 more source