Results 51 to 60 of about 972,292 (339)
Imeglimin attenuates liver fibrosis by inhibiting vesicular ATP release from hepatic stellate cells
FEBS Letters, EarlyView.Imeglimin, at clinically relevant concentrations, inhibits vesicular ATP accumulation and release from hepatic stellate cells, thereby attenuating purinergic signaling and reducing fibrogenic activation. This mechanism reveals a newly identified antifibrotic action of imeglimin beyond glycemic control.
Seiji Nomura +8 more
wiley +1 more source
Do private sustainability standards contribute to income growth and poverty alleviation? : a comparison of different coffee certification schemes in Ethiopia [PDF]
, 2017 Private sustainability standards are increasingly important in food trade with developing countries, but the implications for smallholder farmers are still poorly understood.
de Mey, Yann +3 more
core +3 more sources
Cancer cell death induced by the NAD antimetabolite Vacor discloses the antitumor potential of SARM1
FEBS Letters, EarlyView.Vacor, a compound converted into the toxic metabolite Vacor adenine dinucleotide (VAD) by the nicotinamide salvage pathway enzymes NAMPT and NMNAT2, exhibits antitumor activity by inducing rapid and complete NAD depletion. We report that Vacor toxicity is limited to cell lines expressing high levels of SARM1, a NAD glycohydrolase.
Giuseppe Ranieri +5 more
wiley +1 more source
Airworthiness Certification of Civil Aviation Materials
Cailiao gongcheng, 2017 Based on years of airworthiness regulations research, combined with the experience of airworthiness certification of civil aviation products, the airworthiness requirement to materials for civil aviation products was analyzed.
SHEN Xiao-ming +2 more
doaj +1 more source
Environmental, Social, and Economic Impacts of Sustainability Certification in the Agricultural Sector – The Current State of Empirical Research [PDF]
, 2011 Various stakeholders involved with sustainability certification are interested in knowing whether certification really fulfills its promises. Business managers who have to determine what type of products to source, consumers who are concerned about ...
Jawtusch, Julia +2 more
core
FEBS Letters, EarlyView.Angiotensin II (AngII), a neuropeptide, interacts with amyloid‐β (Aβ), a key player in Alzheimer's disease. This study reveals that AngII reduces Aβ aggregation and membrane disruption in vitro. Biophysical assays and molecular modeling suggest AngII binds disordered Aβ forms, potentially modulating early amyloidogenic events and contributing to ...
Mohsen Habibnia +5 more
wiley +1 more source
Lifting the lid on organic certification [PDF]
, 2011 CERTCOST, a European research project on the system of certification of organic food ran from 2008 until November 2011 with the aim of providing recommendations to improve the efficiency, transparency, and cost effectiveness of organic food certification
Padel, Susanne
core
FEBS Letters, EarlyView.Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
Ignasi Bofill Verdaguer +7 more
wiley +1 more source
Shipin yu jixieObjectiveA method of two-dimensional liquid chromatograohy was established to simultaneously determine the content of lactoferrin and immunoglobulin G in dairy products.MethodsThe pretreated samples were directly injected into the constructed system ...
CHEN Qin +4 more
doaj +1 more source
Evaluating the IAQ and energy performance of ventilation systems in multifamily buildings [PDF]
E3S Web of ConferencesBuildings must provide Indoor Air Quality (IAQ) to the best of their ability while maintaining high energy efficiency. Mechanical ventilation systems are central to this concern.
Kiani Zohreh +4 more
doaj +1 more source