Results 71 to 80 of about 937,596 (337)

TOMM20 as a driver of cancer aggressiveness via oxidative phosphorylation, maintenance of a reduced state, and resistance to apoptosis

open access: yesMolecular Oncology, EarlyView.
TOMM20 increases cancer aggressiveness by maintaining a reduced state with increased NADH and NADPH levels, oxidative phosphorylation (OXPHOS), and apoptosis resistance while reducing reactive oxygen species (ROS) levels. Conversely, CRISPR‐Cas9 knockdown of TOMM20 alters these cancer‐aggressive traits.
Ranakul Islam   +9 more
wiley   +1 more source

Providing care in underresourced areas: contribution of the physician assistant/associate workforce

open access: yesBMC Health Services Research
Background Prior studies suggest that physician assistants/associates (PAs) are more likely than physicians to work in underresourced areas. However, data characterizing the current PA workforce in health professional shortage areas (HPSAs) and medically
Mirela Bruza-Augatis   +3 more
doaj   +1 more source

Plasma lipidomic and metabolomic profiles in high‐grade glioma patients before and after 72‐h presurgery water‐only fasting

open access: yesMolecular Oncology, EarlyView.
Presurgery 72‐h fasting in GB patients leads to adaptations of plasma lipids and polar metabolites. Fasting reduces lysophosphatidylcholines and increases free fatty acids, shifts triglycerides toward long‐chain TGs and increases branched‐chain amino acids, alpha aminobutyric acid, and uric acid.
Iris Divé   +7 more
wiley   +1 more source

Environmental, Social, and Economic Impacts of Sustainability Certification in the Agricultural Sector – The Current State of Empirical Research [PDF]

open access: yes, 2011
Various stakeholders involved with sustainability certification are interested in knowing whether certification really fulfills its promises. Business managers who have to determine what type of products to source, consumers who are concerned about ...
Jawtusch, Julia   +2 more
core  

Do private sustainability standards contribute to income growth and poverty alleviation? : a comparison of different coffee certification schemes in Ethiopia [PDF]

open access: yes, 2017
Private sustainability standards are increasingly important in food trade with developing countries, but the implications for smallholder farmers are still poorly understood.
de Mey, Yann   +3 more
core   +3 more sources

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan   +10 more
wiley   +1 more source

Consumer perception of different organic certification schemes in five European countries [PDF]

open access: yes, 2011
With the introduction of the new mandatory EU logo for organic food and farming, the various existing organic certification schemes in the European market face a challenge: Producers and retailers might only continue to display the existing organic logos
Hamm, Ulrich, Janssen, Meike
core  

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

open access: yesMolecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu   +11 more
wiley   +1 more source

Comparative analysis of Physician Assistant/Associate National Certifying Examination (PANCE) performance trends: pre and during COVID-19 era

open access: yesBMC Medical Education
Background COVID-19 significantly impacted physician assistant/associate (PA) education programs. Most programs transitioned didactic and clinical education from in-person to remote, and clinical training opportunities diminished. Graduates of accredited
Joshua Goodman   +2 more
doaj   +1 more source

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