Results 71 to 80 of about 940,374 (292)
Survivin and Aurora Kinase A control cell fate decisions during mitosis
Molecular Oncology, EarlyView.Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir +2 more
wiley +1 more source
The European Regulatory Framework and its implementation in influencing organic inspection and certification systems in the EU [PDF]
, 2010 The report presents a review of the most important European and international legislation that set the framework for organic certification, of reports prepared by international agencies working with organic standard setting and certification, and of ...
Belliere, Samanta Rosie +9 more
core
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
Certification Systems as Tools for Natural Asset Building: Potential, Experiences to Date, and Critical Challenges [PDF]
, 2005 Certification systems are becoming important tools to encourage and reward social and environmental responsibility. This paper explores whether these systems, which generally have not been designed for the explicit aim of poverty reduction, can assist ...
Michael E. Conroy
core
Evaluating the IAQ and energy performance of ventilation systems in multifamily buildings [PDF]
E3S Web of ConferencesBuildings must provide Indoor Air Quality (IAQ) to the best of their ability while maintaining high energy efficiency. Mechanical ventilation systems are central to this concern.
Kiani Zohreh +4 more
doaj +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Organic Certification is now available by a Bulgarian company [PDF]
, 2003 Balkan Biocert LTD was registered in January 2003 and has conducted the first inspections in Bulgaria. BALKAN BIOCERT Ltd, a private shareholder company which is fully owned by Bulgarian shareholders, offers inspection and certification services for ...
Heeb, Marlene
core
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Lifting the lid on organic certification [PDF]
, 2011 CERTCOST, a European research project on the system of certification of organic food ran from 2008 until November 2011 with the aim of providing recommendations to improve the efficiency, transparency, and cost effectiveness of organic food certification
Padel, Susanne
core
Answering the Calls of "What's Next" and "Library Workers Cannot Live by Love Alone" through Certification and Salary Research [PDF]
, 2009 Members and staff of the American Library Association (ALA) worked diligently over more than a decade to develop a certification program for public library managers.
Grady, Jenifer
core +1 more source