Results 61 to 70 of about 5,267,635 (285)

Neurochemical Endpoints to Inform Early‐Stage Trials of Spinocerebellar Ataxia 2 and 3 in a Multisite Setting

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neurochemical levels measured by brain MR spectroscopy (MRS) have been proposed as endpoints for clinical trials in early‐stage spinocerebellar ataxia (SCA) trials. We tested their trial‐readiness by quantifying neurochemicals in three affected brain regions in early‐stage cohorts of SCA2 and SCA3, examining their reproducibility in ...
James M. Joers   +19 more
wiley   +1 more source

Electroencephalographic Normalization as a Biomarker of Clinical Recovery in Down Syndrome Regression Disorder

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Down syndrome regression disorder is a syndrome characterized by subacute loss of cognitive, behavioral, and functional abilities in individuals with Down syndrome. Electroencephalography abnormalities are frequently observed during evaluation, but it remains unclear whether these findings represent a dynamic marker of disease ...
Jonathan D. Santoro   +14 more
wiley   +1 more source

Chapar: certified causally consistent distributed key-value stores [PDF]

open access: yesProceedings of the 43rd Annual ACM SIGPLAN-SIGACT Symposium on Principles of Programming Languages, 2016
Today’s Internet services are often expected to stay available and render high responsiveness even in the face of site crashes and network partitions. Theoretical results state that causal consistency is one of the strongest consistency guarantees that is possible under these requirements, and many practical systems provide causally consistent key ...
Lesani, Mohsen   +2 more
openaire   +3 more sources

Cognitive and Neuroimaging Divergence Between Juvenile and Adult FUS Amyotrophic Lateral Sclerosis

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by progressive motor neuron degeneration. Fused in sarcoma (FUS)‐associated juvenile ALS (jALS) represents a distinct and aggressive subgroup with rapid deterioration and poor prognosis.
Alexandra V. Jürs   +7 more
wiley   +1 more source

Thalamo‐Lesional Connectivity Signatures of Bilateral Tonic–Clonic Seizures in Focal Cortical Dysplasia‐Related Epilepsy

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Focal cortical dysplasia (FCD) is the most common etiology of drug‐resistant epilepsy in children. Focal to bilateral tonic–clonic seizures (FBTCS) mark a high risk of drug‐resistant epilepsy and involve thalamocortical circuitry in their generation and propagation.
Hua Xie   +8 more
wiley   +1 more source

Preparation and Certification of Reference Materials for Hydrogen and Oxygen Isotopes in Water

open access: yesYankuang ceshi, 2013
Certified reference materials of water for stable hydrogen and oxygen isotopes were developed and have been used for more than 30 years. However, they no longer meet the requirements for newly developed technologies. New reference materials of water have
ZHANG Lin   +3 more
doaj  

CONSUMERS' WILLINGNESS TO PAY FOR ECO-CERTIFIED WOOD PRODUCTS [PDF]

open access: yes
We use Kriström's simple spike model to assess the factors influencing consumers' willingness to pay a premium for a variety of certified wood products. A survey of over 1600 Pennsylvania and Tennessee residents found that approximately 35% were willing ...
Jakus, Paul M., Jensen, Kimberly L.
core  

Blood RNA Biomarker Signatures for Early Diagnosis and Prognosis in Ischemic and Hemorrhagic Stroke: The IBIS‐CT1 Study

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate the expression of nine blood RNA biomarkers in a clinical trial based on genes previously identified in an experimental monkey model of stroke for diagnosis feasibility and prognostication. Methods IBIS‐CT1 was a prospective longitudinal study enrolling patients with ischemic stroke (IS) or intracerebral hemorrhage (ICH ...
Salomé Retailleau   +11 more
wiley   +1 more source

Suitability of XRF for Routine Analysis of Multi-Elemental Composition: A Multi-Standard Verification

open access: yesMethods and Protocols
This study investigated the suitability of X-ray fluorescence (XRF) analysis for routine multi-elemental composition analysis, checking its analytical capabilities by measuring a wide array of certified reference materials of soil and plant origin.
Riccardo Fedeli   +2 more
doaj   +1 more source

THE WELFARE CONSEQUENCES OF CERTIFIED LABELING FOR CREDENCE ATTRIBUTES [PDF]

open access: yes
Certified labeling for credence attributes is examined using the concepts of pooled and separating equilibria. The analysis addresses a latent credence good demand that differs from a conventional good demand by willingness to pay for the credence ...
Hoehn, John P., Deaton, Brady J., Jr.
core  

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