Results 171 to 180 of about 20,209 (206)

Heterogeneity of Human Ceruloplasmin

Science, 1960
Subfractionation of purified human ceruloplasmin, prepared from plasma of 9109 donors, has been carried out by chromatography on columns of diethylaminoethyl cellulose and hydroxylapatite. Electrophoretic analyses of these subfractions on starch gels, at p H 8.5 and 5.7, reveal the presence of at least four ...
A G, MORELL, I H, SCHEINBERG
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Ceruloplasmin and cardiovascular disease

Free Radical Biology and Medicine, 2000
Transition metal ion-mediated oxidation is a commonly used model system for studies of the chemical, structural, and functional modifications of low-density lipoprotein (LDL). The physiological relevance of studies using free metal ions is unclear and has led to an exploration of free metal ion-independent mechanisms of oxidation.
P L, Fox, B, Mazumder, E, Ehrenwald, C K, Mukhopadhyay   +3 more
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Mitochondrial ceruloplasmin of mammals

Molecular Biology, 2005
Using immunoblotting method it was found out that ceruloplasmin (Cp) polypeptides are revealed in mitochondria of rats, isolated from brain, liver, testicles and mammary gland. Cp is localized in matrix and inner membranes of mitochondria. Its molecular weight corresponds to the non-glycosilated form of the protein. Computer analysis did not reveal any
A V, Vasin, N A, Platonova, R G, Povalikhin, S A, Klotchenko, S A, Samsonov, N V, Tsymbalenko, L V, Puchkova   +6 more
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Molecular pathology of ceruloplasmin

Biochemical Genetics, 1972
Individual preparations of CP isolated from one normal donor and two homozygotes for the “Wilson's disease gene” were subjected to a comparative structural and analytical examination. Analysis of CP tryptic hydrolysate by the peptide map technique revealed 64–66 peptides in each sample.
S A, Neifakh, I M, Vasiletz, M M, Shavlovsky   +2 more
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Ceruloplasmin in neurodegenerative diseases

Brain Research Reviews, 2005
For decades, abnormalities in ceruloplasmin (Cp) synthesis have been associated with neurodegenerative disease. From the early observation that low circulating serum ceruloplasmin levels served as a marker for Wilson's disease to the recent characterization of a neurodegenerative disorder associated with a complete lack of serum ceruloplasmin, the link
Vassiliev V, Harris ZL, Zatta P.
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Ceruloplasmin in neurodegenerative diseases

Biochemical Society Transactions, 2008
Two decades ago, patients lacking circulating serum ceruloplasmin (Cp) presented with neurodegeneration associated with brain iron accumulation. These patients, with mutations in the MCO (multi-copper oxidase), Cp, revealed an essential role for Cp in iron homoeostasis.
Sarah J, Texel, Xueying, Xu, Z Leah, Harris   +2 more
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Reaction of human ceruloplasmin and anion treated ceruloplasmin with diethyldithiocarbamate

Journal of Inorganic Biochemistry, 1985
The reaction of human ceruloplasmin and anion treated ceruloplasmin with diethyldithiocarbamate was studied at pH 5.5. The analysis of optical and EPR spectra at 9 GHz showed that ceruloplasmin contains five paramagnetic copper ions, two of which, X and Y, not involved in enzymatic activity, are chelated by diethyldithiocarbamate; the complex thus ...
M, Herve, A, Garnier-Suillerot, L, Tosi, M, Steinbuch   +3 more
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Liver endothelium desialates ceruloplasmin

Biochemical and Biophysical Research Communications, 1986
Our previous work indicated that ceruloplasmin (CP) is transported through liver endothelium via a receptor-mediated mechanism and is subsequently externalized on the abluminal side. In the present work 125I or 3H-labeled ceruloplasmin was chased through the endothelium and the supernate was subjected to affinity chromatography using RCA120 column ...
S, Irie, M, Tavassoli
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Ceruloplasmin receptors of erythrocytes

Biochemical and Biophysical Research Communications, 1984
Mammalian erythrocytes have been shown to bind 125I labeled ceruloplasmin. Binding was reversible and specific. Scatchard analysis yielded linear plots with a Kd of approximately 5nM. The binding site appeared to be a protein located on the cell surface.
G, Barnes, E, Frieden
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Ceruloplasmin in human semen

Experientia, 1966
La ceruloplasmine a ete determinee dans le liquide spermatique de l'homme. On a trouve des valeurs basses pour cette enzyme et une diminution significative au point de vue statistique a ete observee dans les cas d'azoospermie.
L A, de Abreu, R R, Abreu, H, Povoa
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